Search results for "Lipoprotéines"
showing 2 items of 2 documents
Inflammation et maladies métaboliques : analyse par imagerie du métabolisme des lipoprotéines et lipopolysaccharides au cours de l’inflammation
2021
LPS (lipopolysaccharides) are endotoxins originating from Gram-negative bacteria. They have been extensively described for their ability to interact with and disrupt the intestinal barrier. These toxins are able to cross the gut barrier and to pass into the blood (endotoxemia), leading tolow-grade metabolic inflammation or to a severe inflammatory syndrome (SIRS). Fortunately, some circulating proteins such as PLTP (Phospholipid Transfer Protein) are able to transfer LPS to plasma lipoproteins in order to inactivate and detoxify them.The main goals of this study were to investigate the metabolic fate of LPS from the gut and peritoneal cavity but also the influence of PLTP on these toxins in…
Regulation of the activity of the Cholesteryl Ester Tranfer Protein (CETP) : electrostatics interactions with carboxylic derivatives (Non Esterified …
1997
In human plasma, the cholesteryl ester transfer protein (CETP) plays a key role in lipoprotein metabolism by promoting the net mass transfer of cholesteryl esters from HDL towards apoB-containing lipoproteins, and the transfer of triglycerides from VLDL towards HDL and LDL. Thus CETP arises as a potentially important factor in plasma lipoproteins metabolism, a statement which raised a considerable interest in identifying the factors which may regulate CETP activity.In our in vitro studies, we demonstrated that amphipathic molecules (non esterified fatty acids and retinoic acids) constituted of one carboxylic head group and one hydrophobic carbon chain are able to increase the cholesteryl es…