Search results for "Lisp"

Kansallispuistojen kehitys Keski-Suomessa

2017

Kansallispuistojen perustaminen on keskeinen osa luonnonsuojelun historiaa Suomessa. Tarkoituksenani on selvittää kansallispuistojen kehitystä ja erityisesti niiden perustamisprosessia Keski-Suomessa. Tutkimuksessa keskitytään Pyhä-Häkin, Salamajärven, Isojärven ja Leivonmäen kansallispuistoihin. Lähestymistapani pohjaa ympäristöhistoriaan, eli otan huomioon tutkimuksessa ihmisen ja ympäristön suhteen. Ensimmäiset kansallispuistot perustettiin Suomeen vuonna 1938. Ensimmäinen keskisuomalainen kansallispuisto (Pyhä-Häkki) perustettiin vuonna 195, seuraavat vasta 1980-luvulla. 1950- ja 1970-lukujen välillä kansallispuistojen hoito, kehittäminen ja suunnittelu olivat huonolla tolalla, sillä ka…

Moniperintä ja tyypitys olio-ohjelmointikielissä

2008

Antibody synthesis in roach (Rutilus rutilus); analysis of antibody secreting cells in lymphoid organs with ELISPOT-assay

1994

The roach (Rutilus rutilus L.) which is a cyprinid fish, was immunised with bovine γ-globulin (BGG) and the antibody synthesis was studied by counting the number of specific antibody secreting cells (SASC) in the spleen and anterior kidney, and by measuring the antibody concentration in the circulation. SASCs and the total number of immunoglobulin secreting cells (TISC) were counted with the ELISPOT (enzyme-linked immunospot) assay, and anti-BGG antibodies and the concentration of immunoglobulin in sera were assayed by ELISA (enzyme-linked immunosorbent assay). The present modification of the ELISPOT-assay takes advantage of biotin-avidin amplification and yields easily detectable and nonfa…

Vakavia asioita huumorin merkeissä : Laukaan kunnallispolitiikka ja paikallislehti 1964-1980

2001

Clarice Lispector: Tähden hetki

2020

Kirja-arvostelu teoksesta Clarice Lispector: Tähden hetki, suom. Tarja Härkönen, Teos 2020. nonPeerReviewed

Clarice Lispector: Oppiaika eli nautintojen kirja

2018

Arvostelu teoksesta Clarice Lispector: Oppiaika eli nautintojen kirja suomentanut ja jälkisanat Tarja Härkönen. Teos 2018. nonPeerReviewed

Recovery of Varicella-Zoster Virus–Specific T Cell Immunity after T Cell–Depleted Allogeneic Transplantation Requires Symptomatic Virus Reactivation

2008

Abstract Reactivated varicella-zoster virus (VZV) infection causes herpes zoster and commonly occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because VZV-specific T cell immunity is essential to prevent virus reactivation, we developed an interferon-γ enzyme-linked immunosorbent spot (ELISPOT) assay for the sensitive detection of VZV-reactive T cells at the single-cell level ex vivo. We used this assay to monitor the frequency of VZV-reactive T cells in 17 seropositive patients during the first year after T cell–depleted allo-HSCT. The patients did not receive anti-herpesvirus prophylaxis after stem cell engraftment. Independent of the magnitude of transferred d…

Randomised clinical trial: alisporivir combined with peginterferon and ribavirin in treatment-naïve patients with chronic HCV genotype 1 infection (E…

2015

Summary Background Alisporivir (ALV) is an oral, host-targeting agent with pangenotypic anti-hepatitis C virus (HCV) activity and a high barrier to resistance. Aim To evaluate efficacy and safety of ALV plus peginterferon-α2a and ribavirin (PR) in treatment-naive patients with chronic HCV genotype 1 infection. Methods Double-blind, randomised, placebo-controlled, Phase 3 study evaluating ALV 600 mg once daily [response-guided therapy (RGT) for 24 or 48 weeks or 48 weeks fixed duration] or ALV 400 mg twice daily RGT with PR, compared to PR alone. Following a Food and Drug Administration partial clinical hold, ALV/placebo was discontinued and patients completed treatment with PR only. At that…

Comparison of intramuscular and subcutaneous administration of a herpes zoster live-attenuated vaccine in adults aged ≥50 years: a randomised non-inf…

2015

AbstractZostavax® is a live, attenuated varicella zoster virus (VZV) vaccine developed specifically for the prevention of HZ and PHN in individuals aged ≥50 years. During the clinical development of Zostavax, which was mainly in the US, the vaccine was administrated by the subcutaneous (SC) route. In Europe, many healthcare professionals prefer administering vaccines by the intramuscular (IM) route. This was an open-label, randomised trial conducted in 354 subjects aged ≥50 years. The primary objectives were to demonstrate that IM administration is both non-inferior to SC administration in terms of 4-week post-vaccination geometric mean titres (GMTs), and elicits an acceptable geometric mea…

Enhancing dynamic graphical analysis with the Lisp-Stat language and the ViSta statistical program

2005

Presented is a sample of computerized methods aimed at multidimensional scaling and psychometric item analysis that offer a dynamic graphical interface to execute analyses and help visualize the results. These methods show how the Lisp-Stat programming language and the ViSta statistical program can be jointly applied to develop powerful computer applications that enhance dynamic graphical analysis methods. The feasibility of this combined strategy relies on two main features: (1) The programming architecture of ViSta enables users to add new statistical methods as plug-ins, which are integrated into the program environment and can make use of all the functions already available in ViSta (e.…