Search results for "Lisp"
showing 10 items of 87 documents
NPM-ALK-reactive T-cell responses in children and adolescents with NPM-ALK positive anaplastic large cell lymphoma
2019
ABSTRACT The oncoantigen nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces cellular and humoral immune responses in patients with NPM-ALK-positive anaplastic large cell lymphoma (ALCL). We characterize the NPM-ALK-specific T-cell responses in a cohort of pediatric and adolescent ALCL-patients in remission without Human Leucocyte Antigen (HLA)-preselection. First, we assessed NPM-ALK-reactive T-cell responses and their HLA-class I restriction in patients by using dendritic cells (DCs) transfected with in vitro transcribed (IVT) NPM-ALK-RNA for CD8 (n = 20) or CD3 (n = 9) T-cell stimulation. NPM-ALK-specific T-cells were detected in twelve of 29 patients (nine of 20 with CD8-selected…
Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience.
2008
Some studies have shown that fetal outcome observed in patients using insulin lispro is much the same as in pregnant women using regular insulin. This study aims to analyze the Italian data emerging from a multinational, multicenter, retrospective study on mothers with type 1 diabetes mellitus before pregnancy, comparing those treated with insulin lispro for at least 3 months before and 3 months after conception with those treated with regular insulin. The data collected on pregnant women with diabetes attending 15 Italian centers from 1998 to 2001 included: HbA1c at conception and during the first and third trimesters, frequency of severe hypoglycemic episodes, spontaneous abortions, mode …
Low risk of severe hypoglycaemia in patients with type 2 diabetes mellitus starting insulin therapy with premixed insulin analogues BID in outpatient…
2012
Summary Aims: The choice of insulin at initiation in type 2 diabetes remains controversial. The aim of this study was to assess the occurrence of self-reported severe hypoglycaemia associated with premixed insulin analogues in routine clinical care. Methods: A 12-month, prospective, observational, multicentre study in patients starting a commonly prescribed premixed insulin analogue (either insulin lispro 25/75 or biphasic insulin aspart 30/70, twice daily) after suboptimal glycaemic control on oral antidiabetic agents. Treatment decisions were made solely in the course of usual practice. Results: Study follow-up was completed by 991 (85.5%) of the 1150 patients enrolled. At baseline, me…
Urban forest soils harbour distinct and more diverse communities of bacteria and fungi compared to less disturbed forest soils.
2022
Anthropogenic changes to land use drive concomitant changes in biodiversity, including that of the soil microbiota. However, it is not clear how increasing intensity of human disturbance is reflected in the soil microbial communities. To address this issue, we used amplicon sequencing to quantify the microbiota (bacteria and fungi) in the soil of forests (n=312) experiencing four different land uses, national parks (set aside for nature conservation), managed (for forestry purposes), suburban (on the border of an urban area) and urban (fully within a town or city), which broadly represent a gradient of anthropogenic disturbance. Alpha diversity of bacteria and fungi increased with increasin…
La valutazione linguistica. Sperimentazione di un modulo d'esame PFLISP.
2011
HLA-B27-restricted T cells from patients with ankylosing spondylitis recognize peptides from B*2705 that are similar to bacteria-derived peptides
2003
SUMMARY Ankylosing spondylitis (AS) is an inflammatory systemic disease affecting the spine, sacroiliacal and peripheral joints. Although the aetiology of AS remains unknown, the strong association with the HLA-B27 allele might reflect directly a detrimental effect of the HLA-B27 molecule itself, resulting from its potential capability to present ‘arthritogenic’ peptides to CD8+ T cells. Because some forms of SpA are triggered by enterobacterial infection, such arthritogenic peptides might originate from autologous and/or bacterial proteins triggering cross-reactive CD8+ T cell clones. Intriguingly, two peptides from the second extracellular domain of HLA-B*2705 share sequence homologies wi…
I den folkliga modedräktens fotspår : bondekvinnors välstånd, ställning och modemedvetenhet i Gamlakarleby socken 1740-1800
2018
My research study deals with the wealth, social position, and fashion awareness of farmers’ wives in Gamlakarleby (Kokkola) parish in the latter half of the eighteenth century. In addition, I investigate the picture that present national costumes give about eighteenth century dressing. The aim is to examine farmer wives’ wealth in the villages of Karleby (Gamlakarleby socken) and the village of Nedervetil, which were part of the class society regulated by the Church Law of 1686 and the Swedish Civil Code enacted in 1734. The perspective of my research is microhistorical, which means that I study individual persons and phenomena in the villages of Gamlakarleby parish, and I mention the perso…
Sarkaviitat laulavat jo viimeistä virttään : etnologinen tutkimus pukeutumisen diskursseista suomalaisissa sanomalehdissä 1875-1885
2014
Tutkin pro gradu -tutkielmassani, millaista todellisuutta muotia ja kansan- ja kansallispukuja käsittelevät tekstit tuottavat ja miksi jotkut diskurssit saavat hegemonisen aseman. Tutkimusaineistoni koostuu 38 kirjoituksesta, jotka on julkaistu suomalaisissa sanomalehdissä 1875–1885. Pukeutumisen diskursseja on aikaisemmin tutkittu vastaavista lähteistä melko vähän, joten tutkimukseni tuo syventävää tietoa aikalaisten käsityksistä muuttuvia pukujaan kohtaan ja paljastaa mahdollisia syitä kirjoitusten olemassaololle. Tutkimuksen teoreettinen tausta kytkeytyy aatteellisiin, sivistyksellisiin ja pukeutumiseen liittyviin käsitteisiin. Aineiston metodologisessa lähestymisessä on sovellettu kriit…