Search results for "LoRa"

Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes.

2013

Factor structure analyses have revealed the presence of specific biological system markers in healthy humans and diseases. However, this type of approach in very old persons and in type 2 diabetes (T2DM) is lacking. A total sample of 2,137 Italians consisted of two groups: 1,604 healthy and 533 with T2DM. Age (years) was categorized as adults (≤65), old (66-85), oldest old (>85-98) and centenarians (≥99). Specific biomarkers of routine haematological and biochemical testing were tested across each age group. Exploratory factorial analysis (EFA) by principal component method with Varimax rotation was used to identify factors including related variables. Structural equation modelling (SEM) wa…

The gut microbiota: An emerging risk factor for cardiovascular and cerebrovascular disease

2018

Commensal gut microbiota have recently been implicated in cardiovascular disease (CVD) and cerebrovascular disease. Atherosclerotic plaque formation depends on the colonization status of the host. In addition to host nutrition and the related microbiota-dependent metabolic changes, activation of innate immune pathways triggers the development of atherosclerosis and supports arterial thrombosis. Gnotobiotic mouse models have uncovered that activation of Toll-like receptor-2 by gut microbial ligands supports von Willebrand factor-integrin mediated platelet deposition to the site of vascular injury. Depending on nutritional factors, the microbiota-derived choline-metabolite trimethylamine N-ox…

The Gut Microbiota as an Influencing Factor of Arterial Thrombosis

2018

The mutualistic gut microbiota does not only impact the development and function of various immune cell types, but it also influences the function of the hepatic vascular endothelium and prothrombotic platelet function. With germ-free mouse models, we have demonstrated that gut-derived microbial-associated molecular patterns could stimulate hepatic von Willebrand factor (VWF) synthesis and plasmatic VWF levels through Toll-like receptor-2 (TLR2), thus defining the extent of platelet deposition to the subendothelial matrix of the ligation-injured common carotid artery. In addition to the microbiota-derived choline metabolite trimethylamine N-oxide and the microbiota's regulatory role on the …

Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions.

2003

Abstract The enzymes 5-lipoxygenase and elastase are therapeutic targets in dermatological disorders such as psoriasis. Fifteen extracts from traditional Chinese medicinal plants used to treat topical inflammations were screened for their inhibitory effect on lipoxygenase, cyclooxygenase and elastase activity in intact leukocytes and platelets. Astragalus membranaceus, Forsythia suspensa and Poria cocos inhibited 5-lipoxygenase, with IC50 values of 141, 80 and 141 μg mL−1, respectively. The latter two species, along with Angelica dahurica and Angelica pubescens, also inhibited elastase (IC50 values of 80, 123, 68 and 93 μg mL−1, respectively), while A. pubescens, Atractylodes macrocephala, …

Anemone ranunculoides L., novedad para la flora leonesa

2016

Hemos localizado la primera población de Anemone ranunculoides L. en la provincia de León (España), lo que representa el límite occidental de la corología de la especie. Se trata de una planta de floración temprana, propia de ambientes boscosos planocaducifolios. Su rareza en el contexto peninsular ha dotado a este taxon de distintas formas de protección. En Castilla y León está incluida en el Inventario de Especies de Atención Preferente, lo que implica una especial conservación de las poblaciones existentes. We have located the first Anemone ranunculoides L. population in the province of Leon (Spain), representing the western boundary of the chorology of the specie. It is an early floweri…

Botanical excursions in central and Western Sicily - Field Guide For the 60th IAVS Symposium

2017

Kauranoid dieterpenes in Espeletia grandiflora

1971

Abstract The resin of Espeletia grandiflora contains (-)-kaur-16-en-19-ol, (-)-kaur-16-en-19-al (not previously isolated from natural sources), (-)-kaur-16-ene and (-)-kaur-16-en-19-oic acid.

Actualización de las categorías de amenaza para la flora vascular de Andorra

2016

Desde la publicación en el año 2008 de la Check-list i Llista vermella de la flora d’Andorra, el Centre d’Estudis de la Neu i de la Muntanya d’Andorra (CENMA) ha ido realizando un seguimiento anual por ambientes de algunos de los taxones más amenazados a nivel nacional. Durante este estudio también se han recogido datos poblacionales y su estado de conservación con el objetivo de conseguir una información completa para la reevaluación de las categorías de amenaza. En este trabajo se presentan nuevas citas de 50 especies amenazadas de Andorra localizadas entre los años 2012 y 2015 y, cuando ha sido necesario, se ha cambiado la categoría según criterios de la UICN. Palabras clave: conservació…

Nuevos táxones para la checklist de la flora vascular de Andorra

2016

Se actualiza el listado de la flora vascular de Andorra. Con la información de publicaciones externas y trabajos propios del CENMA, se añaden 57 nuevos taxones para el Principado a la checklist vigente desde 2008, siendo el total actual de 1.594 taxones. New taxa for the checklist of vascular plants of Andorra. We update the checklist of vascular plants of Andorra. With external publications or own CENMA’s studies, 57 new taxon have been added for the Principality of Andorra to the current checklist, published in 2008, being 1.594 taxon at present

Aportaciones a la flora vascular de la provincia de Córdoba II (Andalucía, España)

2015

En el presente estudio corológico se aportan 25 taxones que son raros o suponen novedad para alguna comarca o toda la provincia de Córdoba (Andalucía, España). Los taxones más interesantes son Campanula decumbens subsp. baetica Cano-Maqueda & Talavera, Narcissus × susannae Fern. Casas y Plumbago auriculata Lam., ya que son citados por primera vez para esta provincia.