Search results for "Location"

Central functional response to the novel peptide cannabinoid, hemopressin.

2013

Hemopressin is the first peptide ligand to be described for the CB₁ cannabinoid receptor. Hemopressin acts as an inverse agonist in vivo and can cross the blood-brain barrier to both inhibit appetite and induce antinociception. Despite being highly effective, synthetic CB₁ inverse agonists are limited therapeutically due to unwanted, over dampening of central reward pathways. However, hemopressin appears to have its effect on appetite by affecting satiety rather than reward, suggesting an alternative mode of action which might avoid adverse side effects. Here, to resolve the neuronal circuitry mediating hemopressin's actions, we have combined blood-oxygen-level-dependent, pharmacological-ch…

Flexibility in otherwise consistent non-breeding movements of a long-distance migratory seabird, the long-tailed skua

2017

Quantifying within- and between-individual variation in animal migration strategies is a first step towards our understanding of the ability of migrants to adjust to changes in the en - vironment. We studied consistency (or, conversely, flexibility) in movement patterns at large (>1000 km) to meso-scales (100−1000 km) during the non-breeding season of the long-tailed skua Stercorarius longicaudus, a long-distance migratory Arctic seabird, using light-based geolocation. We obtained 97 annual tracks of 38 individuals and quantified similarity between routes. Overall, tracks of the same individual were generally within about 200 to 300 km of their previous year’s route, and more similar than t…

MDP-Based Resource Allocation Scheme Towards a Vehicular Fog Computing with Energy Constraints

2018

As mobile applications deliver increasingly complex functionalities, the demands for even more intensive computation would quickly transcend energy capability of mobile devices. On one hand and in an attempt to address such issues, fog computing paradigm is introduced to mitigate the limited energy and computation resources available within constrained mobile devices, by moving computation resources closer to their users at the edge of the access network. On another hand, most of electric vehicles (EVs), with increasing computation, storage and energy capabilities, spend more than 90% of time on parking lots. In this paper, we conceive the basic idea of using the underutilized computation r…

A Metaheuristic Bandwidth Allocation Scheme for FiWi Networks Using Ant Colony Optimization

2015

Optical-wireless access networks constitute a quite attractive solution to meet the ever-increasing bandwidth requirements of end-users, offering significant benefits such as ubiquitous coverage in the wireless domain and huge bandwidth in the optical domain. However, converging optical and wireless networking technologies, with Passive Optical Networks (PONs) and 4G wireless standards, such as the Worldwide Interoperability for Microwave Access (WiMAX) and the Long Term Evolution (LTE), entails major challenges that need to be addressed. In this context, designing an efficient and fair bandwidth distribution with Quality of Service (QoS) support is a difficult task due to the interdependen…

Perspectives on Dynamic Retirement and Active Ageing

2014

One central goal in ageing individuals’ late-career stages is to participate in working life, subsequently transition successfully into retirement, and to lead a satisfying and healthy life in retirement. In many ways, these goals are aligned with the policy orientation of countries facing challenges with global ageing. This chapter describes some of the current themes of retirement and late-career research, with a specific interest on the role of individual resource allocation strategies and human resource management in promoting the work ability of older employees. It will present the concept of bridge employment in the Finnish context, and the effects of normal retirement, i.e. after rea…

Integrating light‐level geolocation with activity tracking reveals unexpected nocturnal migration patterns of the tawny pipit

2020

Integrated simulation and optimization models for tracking international fixed income indices

2001

Portfolio managers in the international fixed income markets must address jointly the interest rate risk in each market and the exchange rate volatility across markets. This paper develops integrated simulation and optimization models that address these issues in a common framework. Monte Carlo simulation procedures generate jointly scenarios of interest and exchange rates and, thereby, scenarios of holding period returns of the available securities. The portfolio manager’s risk tolerance is incorporated either through a utility function or a (modified) mean absolute deviation function. The optimization models prescribe asset allocation weights among the different markets and also resolve b…

The value of integrative risk management for insurance products with guarantees

2001

Insurance liabilities are converging with capital markets products (e.g. derivatives and securitizations), thereby increasing the demand for integrated asset and liability management strategies. This article compares the value-added by an integrative approach-based on scenario optimization modelling-relative to traditional risk management methods. The authors present some examples of products offered by the insurance industry in Italy, and apply the results of the analysis to the design of competitive insurance policies. © Emerald Backfiles 2007.

Genotypic and Phenotypic Characteristics of Acute Promyelocytic Leukemia Translocation Variants.

2020

Acute promyelocytic leukemia (APL) is a special disease entity of acute myeloid leukemia (AML). The clinical use of all-trans retinoic acid (ATRA) has transformed APL into the most curable form of AML. The majority of APL cases are characterized by the fusion gene PML-RARA. Although the PML-RARA fusion gene can be detected in almost all APL cases, translocation variants of APL have been reported. To date, this is the most comprehensive review of these translocations, discussing 15 different variants. Reviewed genes involved in APL variants include: ZBTB16, NPM, NuMA, STAT5b, PRKAR1A, FIP1L1, BCOR, NABP1, TBLR1, GTF2I, IRF2BP2, FNDC3B, ADAMDTS17, STAT3, and TFG. The genotypic and phenotypic …

Predictors of Early Death in Childhood Acute Promyelocytic Leukemia: Results of an International Retrospective Study

2015

Abstract Background: Acute promyelocytic leukemia (APL) is a rare subtype of childhood acute myeloid leukemia (AML). Bleeding complications occur in 80% of patients at diagnosis and contribute to a higher incidence of early death (ED) in APL compared to other AML subtypes. However, estimates of ED in pediatric APL are imprecise and factors associated with ED in children with APL are unknown. Objectives: To determine the incidence and predictors of ED, defined as death within 60 days from presentation, in childhood APL. Methods: We conducted a retrospective international analysis of children diagnosed with APL between January 1993 and December 2013. The study included 236 patients from the I…