Search results for "Location"
showing 10 items of 1480 documents
The Chaperone Activity of Clusterin is Dependent on Glycosylation and Redox Environment
2014
Background/Aims: Clusterin (CLU), also known as Apolipoprotein J (ApoJ) is a highly glycosylated extracellular chaperone. In humans it is expressed from a broad spectrum of tissues and related to a plethora of physiological and pathophysiological processes, such as Alzheimer's disease, atherosclerosis and cancer. In its dominant form it is expressed as a secretory protein (secreted CLU, sCLU). During its maturation, the sCLU-precursor is N-glycosylated and cleaved into an α- and a β-chain, which are connected by five symmetrical disulfide bonds. Recently, it has been demonstrated that besides the predominant sCLU, rare intracellular CLU forms are expressed in stressed cells. Since these for…
Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms.
2019
Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosophila using a mitochondrially-targeted Type I restriction endonuclease (mtEcoBI) results in unexpected metabolic reprogramming in adult flies, distinct from effects on OXPHOS. Carbohydrate utilization was repressed, with catabolism shifted towards lipid oxidation, accompanied by elevated serine synthesis. Cleavage and translocation, the two modes of mtEcoBI action, repressed carbohydrate rmetabolism via two different mechanisms. DNA cleavage activ…
Some recent contributions to routing and location problems
2003
CORAL 2003, a Conference on Routing and Location, washeld in Puerto de la Cruz (Tenerife, Spain) from February24–26, 2003. A wonderful place, close to the black sand ofthe beach, and a nice temperature welcomed a group ofsenior and young researchers from Canada, England,France, Germany, and Spain. Social activities were alsoprovided and sponsored by the Cabildo Insular de Tenerife(the local government) and TITSA (the public bus transpor-tation company on the island). The conference corre-sponded to the third annual meeting of a research project,funded by the Spanish Ministry of Science and Technology,developing a Decision Support System for Vehicle Routingand Facility Location Problems (SAD…
Prediction of arrival times and human resources allocation for container terminal
2011
Increasing competition in the container shipping sector has meant that terminals are having to equip themselves with increasingly accurate analytical and governance tools. A transhipment terminal is an extremely complex system in terms of both organisation and management. Added to the uncertainty surrounding ships’ arrival time in port and the costs resulting from over-underestimation of resources is the large number of constraints and variables involved in port activities. Predicting ships delays in advance means that the relative demand for each shift can be determined with greater accuracy, and the basic resources then allocated to satisfy that demand. To this end, in this article we pro…
Surface–bottom relationships in the Gulf of Salerno (Tyrrhenian Sea) over the last 34 kyr: Compositional data analysis of palaeontological proxies an…
2009
The palaeontological, geochemical and mineralogical records of core GNS84-C106 were analysed in order to reconstruct palaeohydrological changes and palaeoproductivity patterns in the Gulf of Salerno for the last 34 kyr. This approach, including compositional analysis of planktonic and benthic assemblages, gave an insight into the relationships between continental, sea surface and bottom environmental changes. The main source of variability of planktonic and benthic assemblages is related respectively to sea surface temperature and palaeobathymetry. Interrelated changes in surface salinity, nutrients, density gradient in the water column and organic fluxes at the bottom act as a secondary fa…
An Optimized Roadside Units (RSU) Placement for Delay-Sensitive Applications in Vehicular Networks
2015
International audience; Over the last few years, a lot of applications have been developed for Vehicular Ad Hoc NETworks (VANETs) to exchange information between vehicles. However, VANET is basically a Delay Tolerant Network (DTN) characterized by intermittent connectivity, long delays and message losses especially in low density regions [1]. Thus, VANET requires the use of an infrastructure such as Roadside Units (RSUs) that permits to enhance the network connectivity. Nevertheless, due to their deployment cost, RSUs need to be optimally deployed. Hence, the main objective of this work is to provide an optimized RSUs placement for delay-sensitive applications in vehicular networks that imp…
Sex Allocation in Haplodiploid Cyclical Parthenogens with Density‐Dependent Proportion of Males
1998
Departament de Microbiologia i Ecologia, Universitat de Birky and Gilbert 1971; Wallace and Snell 1991), which Valencia, E46100-Burjassot (Valencia), Spain includes an asexual (amictic) and a sexual (mictic) phase, the diapausing form being the sexually produced resting Submitted September 22, 1997; Accepted April 21, 1998 egg. Habitat colonization begins when the resting eggs hatch and emerge from the sediments. With these hatchlings, the amictic phase starts, which is a repeated sequence of amictic females parthenogenetically produc
Effect of Thermomechanical and Static Loading on the Load to Fracture of Metal‐Ceramic, Monolithic and Veneered Zirconia Posterior Fixed Partial Dent…
2018
PURPOSE To evaluate the influence of static (not preloaded) and thermomechanical loading on the load to fracture of metal-ceramic, monolithic and veneered zirconia computer-aided design/computer-aided manufacturing (CAD/CAM) posterior fixed partial dentures (FPDs). MATERIALS AND METHODS One hundred standardized specimens with 2 abutments screwed onto a platform were prepared from stainless steel to receive a posterior 3-unit FPD with an intermediate pontic. Specimens were randomly divided into 5 groups (n = 20): Metal-ceramic (control group), Lava Zirconia system, Vita In-Ceram YZ, IPS e.max ZirCAD, and Lava Plus. Half of the specimens of each group (n = 10) underwent no preloading, and the…
Determination of Concentration Profiles of Methyl Mercury Compounds in Surface Waters of Polar and other Remote Oceans by GC-AFD
1998
Abstract The concentration of monomethyl mercury (MeHg+) and dimethyl mercury (Me2Hg) was determined in surface sea-water samples of the Antarctic and Arctic Ocean as well as of other remote areas (South Atlantic and South Pacific) during expeditions of the German research vessel “Polarstern”. A purge and trap/gas chromatographic system, equipped with an atomic fluorescence detector (AFD), was used. For the analysis of MeHg+ conversion into the volatile methylethyl mercury by reaction with tetraethyloborate prior to the purging process was carried out. The detection limit for both methylated mercury compounds was 5 pg Hg/L, which allowed their determination in most ocean water samples even …
Uptake and translocation monitoring of imidacloprid to chili and tomato plants by molecularly imprinting extraction - ion mobility spectrometry
2019
Abstract The degradation of imidacloprid in soil and its uptake and translocation to chili and tomato plants was evaluated, as a proof of concept, of the possibilities of the combination of molecularly imprinted polymers (MIPs) and ion mobility spectrometry (IMS) for a fast and sensitive bioprocesses monitoring tool. To do it, a method based on the selective extraction of imidacloprid from soil and plant materials was developed. In the selected conditions, the MIP-IMS procedure provided a recovery of imidacloprid in soil and plant samples from 102 to 114%, for spiked concentration levels from 0.2 to 2.0 μg g−1. Precision of the methodology, expressed as the relative standard deviation (RSD)…