Search results for "Location"
showing 10 items of 1480 documents
Imiquimod-Induced Psoriasis in Mice Depends on the IL-17 Signaling of Keratinocytes
2018
The pathology of psoriasis strongly depends on IL-17A. Monoclonal antibodies blocking either the cytokine or its receptor are among the most efficient treatments for psoriatic patients. Keratinocytes can be activated upon exposure to IL-17A and tumor necrosis factor-α and secrete secondary cytokines and chemokines in the inflamed skin. In psoriasis and its imiquimod-induced mouse model, a strong skin infiltration of neutrophils and inflammatory monocytes can be observed. However, to date, it is not clear how exactly those cellular populations are attracted to the skin and how they contribute to the pathogenesis of the disease. To define the crucial cell type responding to IL-17 and initiati…
First guidelines for unilateral cT1 renal tumor management
2010
Current treatment options for clinical stage T1 renal tumors, in patients with a contralateral healthy kidney, are diverse. The first guidelines for the management of these lesions have recently been published, which state that tumor size and health status of the patient are important factors to consider. The inclusion of tumor location, patient age and major comorbidities might strengthen these guidelines in the future.
Exploration of Location-Based Services Adoption
2011
The purpose of this chapter is to explore aspects of user perceptions of their use of location-based services. As mobile technologies become more ubiquitous in the general population, it is reasonable to assume that individuals will consume services and software to enhance their aspirations and entertainment desires. This study begins by constructing a location-based service prototype simulation. It then conducts an experiment and analysis based on the Unified Theory of Acceptance and Use of Technology (UTAUT) model. A survey was developed to extract usage information from participants, followed by an analysis of the results using PLS. The analysis shows significant indicators that suggest …
A Personal LPWAN Remote Monitoring System
2021
Firefighters are equipped with an immobility detector device also called the Personal Alert Safety System (PASS) that is integrated into the user's Self-Contained Breathing Apparatus (SCBA). If a firefighter remains motionless for a certain period of time, a loud audible alert is triggered to notify the Firefighter Assist and Search Team (FAST) deployed in the area of intervention that the wearer of the PASS device is in trouble and in need of rescue. However, this device is not reliable enough since it triggers frequently false positives which lead to developing a tolerance for sounding alarms among the crew. As a consequence, they do not seem to be concerned about it as they should and th…
Spectrum utilization over licensed and unlicensed bands
2016
Nowadays, telecommunication technology becomes one of the universal phenomenon used in people’s daily life. In recent years, the appearance of smartphones, tab lets, mobile Internet Apps and services led to mobile data traffic proliferating, and the devices and ser- vices will continue to increase dramatically for some time. The fact along with the tele- communication devices increasing to aggravate the overload problem is that the users seek for fast and reliable data transmission, as well as service continuity. To address the over- load issue, LTE-Unlicensed (LTE-U) turns out to be one of the reasonable solutions to provide high performance and seamless interoperability for users’ experie…
Post-Migratory Employment Prospects: Evidence from Finland
2000
This paper analyses the role which migration plays in improving post-migratory employment prospects of migrants (long-distance) within Finland, by examining the employment status of migrants and non-migrants at the end of the migration interval. The analysis is based on micro data from the period 1985–90. The results from multivariate analyses suggest that migration by itself has not augmented the likelihood of getting a job, even though tabular comparisons of re-employment rates between migrants and non-migrants suggest this to be the case. Migration, however, has an indirect role in enhancing job search outcomes as it moves workers to labour markets characterized by more favourable employ…
Cutaneous RANK-RANKL Signaling Upregulates CD8-Mediated Antiviral Immunity during Herpes simplex Virus Infection by Preventing Virus-Induced Langerha…
2015
Herpes simplex virus-type 1 (HSV-1) causes the majority of cutaneous viral infections. Viral infections are controlled by the immune system, and CD8(+) cytotoxic T-lymphocytes (CTLs) have been shown to be crucial during the clearance of HSV-1 infections. Although epidermal Langerhans cells (LCs) are the first dendritic cells (DCs) to come into contact with the virus, it has been shown that the processing of viral antigens and the differentiation of antiviral CTLs are mediated by migratory CD103+ dermal DCs and CD8 alpha(+) lymph node resident DCs. In vivo regulatory T-cells (Tregs) are implicated in the regulation of antiviral immunity and we have shown that signaling via the receptor activ…
Comparison among three boundary element methods for torsion problems: CPM, CVBEM, LEM
2011
This paper provides solutions for De Saint-Venant torsion problem on a beam with arbitrary and uniform cross-section. In particular three methods framed into complex analysis have been considered: Complex Polynomial Method (CPM), Complex Variable Boundary Element Method (CVBEM) and Line Element-less Method (LEM), recently proposed. CPM involves the expansion of a complex potential in Taylor series, computing the unknown coefficients by means of collocation points on the boundary. CVBEM takes advantage of Cauchy’s integral formula that returns the solution of Laplace equation when mixed boundary conditions on both real and imaginary parts of the complex potential are known. LEM introduces th…
Length-scale effects in the nucleation of extended dislocations in nanocrystalline Al by molecular-dynamics simulation
2001
The nucleation of extended dislocations from the grain boundaries in nanocrystalline aluminum is studied by molecular-dynamics simulation. The length of the stacking fault connecting the two Shockley partials that form the extended dislocation, i.e., the dislocation splitting distance, rsplit, depends not only on the stacking-fault energy but also on the resolved nucleation stress. Our simulations for columnar grain microstructures with a grain diameter, d, of up to 70 nm reveal that the magnitude of rsplit relative to d represents a critical length scale controlling the low-temperature mechanical behavior of nanocrystalline materials. For rsplit>d, the first partials nucleated from the bou…
Housing conditions modulate the reinforcing properties of cocaine in adolescent mice that binge on fat
2017
Abstract Binge eating is a specific form of overeating characterized by intermittent, excessive eating. To date, several studies have addressed the effects that bingeing on fat has on the rewarding effects of drugs of abuse, but they have found contradictory and highly variable results. Housing conditions could modulate these results, as most studies employ isolated animals to measure the exact amount of food that is ingested. The aim of this study was to evaluate the effects of housing conditions on the response of mice to cocaine, modulated by bingeing on a high-fat diet during adolescence. After 40 days of binge-eating for 2 h, three days a week (PND 29–69), the reinforcing effects of a …