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showing 10 items of 1480 documents
Serological prevalence of toxoplasmosis in pregnant women in Luanda (Angola): Geospatial distribution and its association with socio-demographic and …
2020
We report a study on toxoplasmosis in pregnant women in Luanda, Angola, determining the seroprevalence, geospatial distribution and its association with socio-economic features, dietary habits and hygiene and health conditions. Anti-Toxoplasma gondii IgG and IgM were quantified in serum samples of women attended at the Lucrecia Paim Maternity Hospital between May 2016 and August 2017. The IgG avidity test and qPCR assay were used for dating the primary infection. Data were collected by questionnaire after written consent, and spatial distribution was assessed through a Kernel Density Function. The potential risk factors associated with Toxoplasma infection were evaluated using bivariate and…
Mutational analysis of the RNA-binding domain of the Prunus necrotic ringspot virus (PNRSV) movement protein reveals its requirement for cell-to-cell…
2005
AbstractThe movement protein (MP) of Prunus necrotic ringspot virus (PNRSV) is required for cell-to-cell movement. MP subcellular localization studies using a GFP fusion protein revealed highly punctate structures between neighboring cells, believed to represent plasmodesmata. Deletion of the RNA-binding domain (RBD) of PNRSV MP abolishes the cell-to-cell movement. A mutational analysis on this RBD was performed in order to identify in vivo the features that govern viral transport. Loss of positive charges prevented the cell-to-cell movement even though all mutants showed a similar accumulation level in protoplasts to those observed with the wild-type (wt) MP. Synthetic peptides representin…
Chromosome 1 abnormalities in myeloid malignancies: a literature survey and karyotype-phenotype associations.
2009
Chromosome 1 is the largest human chromosome and contains over 1600 known genes and 1000 novel coding sequences or transcripts. It is, therefore, not surprising that recurrent chromosome 1 abnormalities are regularly encountered in both neoplastic and non-neoplastic medical conditions. The current review is focused on myeloid malignancies where we summarize the relevant published literature and discuss specific karyotype-phenotype associations. We show that chromosome 1 abnormalities are most frequent in BCR-ABL-negative classic myeloproliferative neoplasms (MPN): polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Specific abnormalities include duplicat…
Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition
2020
Abstract The interaction of menin (MEN1) and MLL (MLL1, KMT2A) is a dependency and provides a potential opportunity for treatment of NPM1-mutant (NPM1mut) and MLL-rearranged (MLL-r) leukemias. Concomitant activating driver mutations in the gene encoding the tyrosine kinase FLT3 occur in both leukemias and are particularly common in the NPM1mut subtype. In this study, transcriptional profiling after pharmacological inhibition of the menin-MLL complex revealed specific changes in gene expression, with downregulation of the MEIS1 transcription factor and its transcriptional target gene FLT3 being the most pronounced. Combining menin-MLL inhibition with specific small-molecule kinase inhibitors…
When to be sexual: sex allocation theory and population density-dependent induction of sex in cyclical parthenogens
2008
The timing of sex is a critical fitness component in the cyclically parthenogenetic life-cycle of rotifers. It has been hypothesized that sex in rotifers is optimally timed to high population density because male‐female encounters are more probable. Because sexual females produce either males or, if inseminated, diapausing eggs, the advantage of a higher male‐female encounter rate is that allocation to male production can be lower. This is paradoxical in the context of the sex allocation theory developed for rotifers, as the theory predicts equal numbers of male-producing and diapausing-egg producing females. We investigated this paradox using both empirical data and theoretical analysis. L…
Randomized Comparative Trial with Ceftizoxime and Cefotaxime in Urinary Tract Infections
1984
Ceftizoxime, a new, semisynthetic, beta-lactamase-resistant cephalosporin, is not metabolized in man and is excreted almost entirely as the original active compound in the urine. The efficacy and safety of ceftizoxime were assessed in 80 patients with acute and chronic urinary infections, with and without associated pathological conditions, in comparison with cefotaxime. Two dosage schedules, 1 g or 0.5 g every 12 h, i.v. or i.m. for 10 days, were adopted according to the severity of each case and to separate randomization tables for each schedule; causal agents were all sensitive to both drugs in vitro. The overall results were excellent. Safety was excellent in almost all cases. In this t…
The effect of intracavernosal growth differentiation factor-5 therapy in a rat model of cavernosal nerve injury.
2006
OBJECTIVE To determine whether the intracavernosal application of growth differentiation factor-5 (GDF-5) influences nerve regeneration and erectile function after cavernosal nerve injury in a rat model. MATERIALS AND METHODS Thirty-two male Sprague-Dawley rats were randomly divided into four equal groups: eight had a sham operation (uninjured controls), while 24 had bilateral cavernosal nerve crush. The crush-injury groups were treated at the time of injury with an impregnated collagen sponge implanted into the right corpus cavernosum. The sponge contained no GDF-5 (injured controls), 2 µg (low concentration), or 20 µg GDF-5 (high concentration). Erectile function was assessed by cavernosa…
Emigration speed and the production of sexuals in colonies of the ant Temnothorax crassispinus under high and low levels of disturbance
2016
A nest relocation is costly for social insects, and involves hazards. Emigrations were studied in Temnothorax crassispinus ant colonies, which inhabit ephemeral nest sites, and which frequently change their nests. In a laboratory experiment, ant colonies from one group were forced to change their nest sites 10 times over a ca. 3-month period, whilst colonies from the second group were forced to adopt this practice twice (on the beginning of May, and in the second half of July). Colonies of the ant from both the groups reduced their total emigration duration. However, the duration of the transport phase remained unchanged. In the case of colonies with higher level of disturbance, there was n…
The cavity-nest ant Temnothorax crassispinus prefers larger nests
2014
Colonies of the ant Temnothorax crassispinus inhabit mostly cavities in wood and hollow acorns. Typically in the field, nest sites that can be used by the ant are a limited resource. In a field experiment, it was investigated whether the ants prefer a specific size of nest, when different ones are available. In July 2011, a total of 160 artificial nests were placed in a beech-pine forest. Four artificial nests (pieces of wood with volume cavities, ca 415, 605, 730, and 980 mm3, respectively) were located on each square meter of the experimental plot. One year later, shortly before the emergence of new sexuals, the nests were collected. In July 2012, colonies inhabited more frequently bigger…
A CAPWAP-Compliant Solution for Radio Resource Management in Large-Scale 802.11 WLAN
2007
Recently, the impressive success of the IEEE 802.11 WLAN technology has dramatically changed the role of the wireless connectivity provisioning. Born as a wireless extension of small office or home networks, todays the WLANs are getting more and more popular as a large, even metropolitan, area networks. The deployment of large-scale WLANs has some critical issues, because of the lack of coordinated management functionalities among the network nodes. In this paper we briefly describe the CAPWAP architectural solution, for centralizing some control and maintenance functionalities in large scale WLAN, by guaranteeing the interoperability between network nodes provided by different vendors. We …