Search results for "Locke"

Potassium-inhibited processing of IL-1 beta in human monocytes.

1995

Agents that deplete cells of K+ without grossly disrupting the plasma membrane were found to stimulate the cleavage of pro-interleukin (IL)-1 beta to mature IL-1 beta. Agents examined in this study included staphylococcal alpha-toxin and gramicidin, both of which selectively permeabilize plasma membranes for monovalent ions, the ionophores nigericin and valinomycin, and the Na+/K+ ATPase inhibitor ouabain. K+ depletion by brief hypotonic shock also triggered processing of pro-IL-1 beta. The central role of K+ depletion for inducing IL-1 beta maturation was demonstrated in cells permeabilized with alpha-toxin: processing of pro-IL-1 beta was totally blocked when cells were suspended in mediu…

Nontumorous portal vein thrombosis in liver cirrhosis: Possible role of β-blockers

2018

<b><i>Objective:</i></b> Nonselective β-blockers (NSBB) are used in liver cirrhosis (LC) to prevent variceal bleeding because they decrease portal pressure. A main risk factor for the development of portal vein thrombosis (PVT) in LC is decreased portal vein inflow velocity. The aim of our study was to examine retrospectively the incidence of PVT and its correlation with the use of β-blockers in a cohort of LC patients. <b><i>Subjects and Methods:</i></b> Data from 230 LC patients (90% Child-Pugh class A), who had been followed up for at least 5 years, were reviewed. The diagnosis of PVT was made by ultrasound. The presence of PVT was evaluate…

Locke: sustancia e identidad personal. (Metafísica y epistemología en los orígenes del capitalismo)

2014

Este capítulo del libro colectivo: De la libertad del mundo, homenaje a Juan Manuel Navarro Cordón, expone la teoría de la identidad personal que John Locke propuso en su Ensayo sobre el entendimiento humano reflexionando sobre su significación no solo epistemológica y ontológica sino también política.

D'un chardonneret impertinent (Locke) à l'animal pathétique (Mercier)

2008

Avicenna’s Outsourced Rationalism

2020

This paper refutes the claim that Avicenna's theory of science is empiricist in the robust, Lockean sense. I argue that his denial of innatism notwithstanding, the theory of formal identity, together with the metaphysical idea that the ontological structure of the sublunary world is grounded in the active intellect, commits Avicenna to a peculiar kind of rationalism in which the ultimate source of knowledge is an intellect, albeit one extraneous to the human mind. I then introduce two hitherto insufficiently discussed texts to challenge this conclusion. In the end, I claim that although this new material may provide some evidence for a robust empiricism in Avicenna, its consequences remaine…

Synaesthesia through the blind man’s eyes

2014

International audience

Nonlinear Analysis of Phase-Locked Loop (PLL): Global Stability Analysis, Hidden Oscillations and Simulation Problems

2013

In the middle of last century the problem of analyzing hidden oscillations arose in automatic control. In 1956 M. Kapranov considered a two-dimensional dynamical model of phase locked-loop (PLL) and investigated its qualitative behavior. In these investigations Kapranov assumed that oscillations in PLL systems can be self-excited oscillations only. However, in 1961, N. Gubar’ revealed a gap in Kapranov’s work and showed analytically the possibility of the existence of another type of oscillations, called later by the authors hidden oscillations, in a phase-locked loop model: from a computational point of view the system considered was globally stable (all the trajectories tend to equilibria…

L'origine des sciences humaines dans l'anthropologie animale des Lumières : de Locke et Tyson aux idéologues

2008

Cycles in continuous and discrete dynamical systems : computations, computer-assisted proofs, and computer experiments

2009

The present work is devoted to calculation of periodic solutions and bifurcation research in quadratic systems, Lienard system, and non-unimodal one-dimensional discrete maps using modern computational capabilities and symbolic computing packages.In the first chapter the problem of Academician A.N. Kolmogorov on localization and modeling of cycles of quadratic systems is considered. For the investigation of small limit cycles (so-called local 16th Hilbert’s problem) the method of calculation of Lyapunov quantities (or Poincaré-Lyapunov constants) is used. To calculate symbolic expressions for the Lyapunov quantities the Lyapunov method to the case of non-analytical systems was generalized. …

Simulation of PLL with impulse signals in MATLAB: Limitations, hidden oscillations, and pull-in range

2015

The limitations of PLL simulation are demonstrated on an example of phase-locked loop with triangular phase detector characteristic. It is shown that simulation in MatLab may not reveal periodic oscillations (e.g. such as hidden oscillations) and thus may lead to unreliable conclusions on the width of pull-in range.