Search results for "Locke"
showing 10 items of 332 documents
Effects of clinical and laboratory variables at admission and of in-hospital treatment with cardiovascular drugs on short term prognosis of ischemic …
2011
Abstract Introduction No information exists, to our knowledge, about the possible role of cardiovascular drug administration in the acute phase of ischemic stroke and possible effects on stroke outcome. The aim of our study was to evaluate the relationship between in-hospital treatment with cardiovascular drugs in patients with acute ischemic stroke and some outcome indicators. Methods and Results 1096 subjects enrolled in the GIFA study, who had a main discharge diagnosis of ischemic stroke represent the final sample. Drugs considered for the analysis were the following: ACE-inhibitors (ACEI), angiotensin II receptor blockers (ARBs), statins, calcium-channel-blockers (CCBs), antiplatelet (…
Metabolic and Cardiovascular Effects of Switching Thiazides to Amlodipine in Hypertensive Patients With and Without Type 2 Diabetes (the Diuretics an…
2020
Background: Different studies have indicated that thiazide diuretics can increase the risk of developing type 2 diabetes (T2D). Therefore, in this study, we investigated whether switching from hydrochlorothiazide (HCTZ) to amlodipine resulted in ameliorating different cardiovascular and metabolic measures in hypertensive patients with or without T2D. Methods: This study [Diuretics and Diabetes Control (DiaDiC)] was a 6-week, single-blind, single-center randomized controlled trial. The first 20 normal glucose-tolerant, 20 prediabetic, and 20 T2D consecutive patients were randomized to continue the previous antihypertensive treatment with HCTZ (12.5-25 mg/day) or to switch from HCTZ to amlodi…
Acute relaxant effects of 17-beta-estradiol through non-genomic mechanisms in rabbit carotid artery.
2002
Estrogens could play a cardiovascular protective role not only by means of systemic effects but also by means of direct effects on vascular structure and function. We have studied the acute effects and mechanisms of action of 17-beta-estradiol on vascular tone of rabbit isolated carotid artery. 17-Beta-estradiol (10, 30, and 100 microM) elicited concentration-dependent relaxation of 50 mM KCl-induced active tone in male and female rabbit carotid artery. The stereoisomer 17-alpha-estradiol showed lesser relaxant effects in male rabbits. Endothelium removal did not modify relaxation induced by 17-beta-estradiol. The NO synthase inhibitor L-NAME (100 microM) only reduced significantly relaxati…
Effectiveness and Tolerability of Fixed-Dose Combination Enalapril plus Nitrendipine in Hypertensive Patients Results of the 3-Month Observational, P…
2009
Background and objective: Monotherapy with any class of antihypertensive drug effectively controls blood pressure (BP) in only about 50% of patients. Consequently, the majority of patients with hypertension require combined therapy with two or more medications. This study aimed to evaluate the effectiveness (systolic BP [SBP]/diastolic BP [DBP] control) and tolerability of the fixed-dose combination enalapril/nitrendipine 10 mg/20 mg administered as a single daily dose in hypertensive patients. Methods: This was a post-authorization, multicentre, prospective, observational study conducted in primary care with a 3-month follow-up. Patients throughout Spain with uncontrolled hypertension (>= …
Ten-year outcome after coronary angioplasty in patients with single-vessel coronary artery disease and comparison with the results of the Coronary Ar…
2000
The 10-year results of randomized trials comparing percutaneous transluminal coronary angioplasty (PTCA) in patients with single-vessel coronary artery disease (CAD) with coronary artery bypass grafting (CABG) and medical treatment are not available yet. The aim of this evaluation was to compare our 10-year follow-up results after PTCA in patients with single-vessel CAD with the 10-year follow-up results after CABG and medical treatment in the Coronary Artery Surgery Study (CASS) trial. We evaluated the clinical outcome of 509 patients with single-vessel CAD 10 years after coronary angioplasty. The data were compared with the results of 214 patients with single-vessel CAD after CABG or medi…
Broadband tuning of a long-cavity all-fiber mode locked Thulium-doped fiber laser using an acousto-optic bandpass filter
2019
A long-cavity passively mode-locked thulium-doped all-fiber laser is reported incorporating a tapered acousto-optic tunable bandpass filter (AOTBF). The operation of the AOTBF relies on the intermodal coupling between core and cladding modes when a flexural acoustic wave propagates along an 80-microm tapered fiber. The filter works in transmission and exhibits a 3-dB bandwidth of 9.02 nm with an insertion loss of 3.4 dB. The laser supports ultrashort pulse generation at a low repetition rate of 784.93 kHz. Optical pulses with 2.43 nm of optical bandwidth and 2.1 ps pulse duration were obtained in a broad tuning range from 1824.77 to 1905.16 nm.
Actively mode-locked all-fiber laser by 5 MHz transmittance modulation of an acousto-optic tunable bandpass filter
2018
Active mode-locking of an all-fiber ring laser by transmittance modulation of an in-fiber acousto-optic tunable bandpass filter (AOTBF) is reported. Cavity loss modulation is achieved by full acousto-optic mode re-coupling cycle induced by standing flexural acoustic waves. The modulator permits the implementation of 28 dB of nonresonant light suppression, 1.4 nm of modulation bandwidth, 74% of modulation depth and 4.11 dB of optical loss in a 72.5 cm-long all-fiber configuration. The effects of the modulated AOTBF on the laser performance are investigated. Transform-limited optical pulses of 8.8 ps temporal width and 6.0 W peak power were obtained at 4.87 MHz repetition rate.
An automated procedure for computing the packing properties of dense and locked sands by image analysis of thin sections
2014
The macroscopic mechanical behaviour of dense sands originates to a great extent from their microstructural characteristics such as the coordination number, the grain contact and the packing density indexes. The study of intergranular contacts and the reckoning of these indexes may be carried out on planar images of the grains either by means of time-consuming visual inspection assisted by CAD or by automatic image analysis. An innovative method for the automatic determination of microstructural characteristics of sands based on image analysis of thin section is proposed. Tests performed on a locked sand show that the proposed method is much more effective, convenient and faster than the us…
Dynamic control of the operation regimes of a mode-locked fiber laser based on intracavity polarizing fibers: experimental and theoretical validation.
2012
[EN] An intracavity polarizing fiber is proposed to control the emission regime of a passively mode-locked fiber laser. Stable operation in self-starting high and low dispersion soliton mode-locking and 100 GHz multiwavelength regimes is demonstrated through numerical simulations and experimental validation. Mode-locking stability is ensured by a saturable absorber in the ring cavity. The effective selection of operation regime is dynamically carried out by controlling the intracavity polarization state.
Long-cavity all-fiber ring laser actively mode locked with an in-fiber bandpass acousto-optic modulator.
2013
We demonstrate low-frequency active mode locking of an erbium-doped all-fiber ring laser. As the mode locker, we used a new in-fiber bandpass acousto-optic modulator showing 74% modulation depth, 3.7 dB power insertion losses, 4.5 nm of optical bandwidth, and 20 dB of nonresonant light suppression. The laser generates 330 ps mode-locked pulses over a 10 ns pedestal, at a 1.538 MHz frequency, with 130 mW of pump power. Fil: Cuadrado Laborde, Christian Ariel. Universidad de Valencia; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigaciones Opticas (i); Argentina. Provincia de Buenos Aires. Gobernación. Comisión de In…