Search results for "Locke"
showing 10 items of 332 documents
A time domain strategy for the measurement of IEEE Standard 1459-2000 power quantities in nonsinusoidal three-phase and single-phase systems
2008
This paper describes a time domain technique for the detection of fundamental and harmonic components of voltages and currents, which is able to evaluate all the quantities required by IEEE standard 1459-2000. The technique does not require any spectral analysis to separate the fundamental positive-sequence components from harmonic, negative-sequence and zero-sequence ones. In the paper the development of the proposed technique is presented for three-phase systems, both three-wires and four-wires, as well as for single-phase systems. The implementation of the proposed technique on a PC-based instrument is also described and experimental results are presented. Finally, accuracy specification…
Fabry nephropathy: 5 years of enzyme replacement therapy-a short review.
2007
Fabry disease is an X-linked lysosomal storage disease, resulting from a deficiency of the enzyme α-galactosidase A and subsequent cellular storage of the enzyme substrate globotriaosylceramide (Gb3) [1]. Estimates of the incidence of Fabry disease vary markedly, from 1:<5000 male births in a newborn screening study in Italy [2] to 1:117 000 male births in Australia [3] and 1:833 000 male births in northern Portugal [4]. In general, hemizygous males are more severely affected than heterozygous females. In males, life expectancy is reduced by an average of 20 years [5] and in females by 15 years [6]. Although males tend to suffer symptoms earlier than females, both boys and girls can be affe…
Locke (la antropología en el siglo XVIII)
1996
Introducción a las concepciones antropológicas y etnológicas de John Locke que se desprenden del Libro I, Cap. III, &9-1O; Libro I Cap. IV, &8 y Libro I, Cap. IV & 12 del Ensayo sobre el Entendimiento Humano y de los parágrafos del Segundo Tratado sobre del Gobierno Civil 1O1, 102, 14, 27, 45-49, 77-8 1,74,76,87,95,90, 106, 107, 108, 112. Traducción de los mismo a a partir de la ediciones críticas inglesas de ambos textos
Modulation of voltage-gated Na+ and K+ channels by pumiliotoxin 251D: A “joint venture” alkaloid from arthropods and amphibians
2008
Abstract Certain amphibians provide themselves with a chemical defense by accumulating lipophilic alkaloids into skin glands from dietary arthropods. Examples of such alkaloids are pumiliotoxins (PTXs). In general, PTXs are known as positive modulators of voltage-gated sodium channels (VGSCs). Unlike other PTXs, PTX 251D does not share this characteristic. However, mice and insect studies showed that PTX 251D is highly toxic and to date the basis of its toxicity remains unknown. In this work, we searched for the possible target of PTX 251D . The toxin was therefore made synthetically and tested on four VGSCs (mammalian rNa v 1.2/β 1 , rNa v 1.4/β 1 , hNa v 1.5/β 1 and insect Para/tipE ) and…
Polymorphism and solvates of flecainide base
2013
Flecainide base is pharmaceutically active substance used for production of flecainide acetate which is known in market as Tambacor, Almarytm, Apocard, Ecrinal or Flecaine. It is determined that flecainide base forms four polymorphic forms abbreviated as Ib, IIb, IIIb and IVb. Flecainide base form Ib is thermodynamically stable form at laboratory temperature while form IIIb is stable at higher temperatures. Flecainide form Ib absorbs water in its structure between layers and forms non-stoichiometric hydrate. Flecainide base binds with organic solvents and form monosolvates. Flecainide base form Ib crystallizes in orthorhombic crystals with lattice parameters a = 27.88 Å, b = 13.78 Å, c = 9.…
All polarization-maintaining passively mode-locked fiber-ring ytterbium-doped laser; from net-normal to net-anomalous dispersion
2020
We investigated the behavior of a fiber-ring polarization-maintaining passively modelocked ytterbium-doped laser in a broad range of dispersion values; i.e., from highly net-normal to net-anomalous, with a special emphasis near the zero of chromatic dispersion. Different lengths of an ad hoc polarization-maintaining photonic crystal fiber were used as intracavity dispersion compensator to shift the operation of this laser from net-normal to the net-anomalous regime. The laser generated the shortest light pulses around the zero of dispersion: 6 ps / 7ps for −0.023 ps2 / 0.045 ps2 ; in both cases, pulses were not transform-limited, being theoretically possible an out-of-cavity recompression d…
LE SITE CAMPANIFORME DE LUX LA PERROUZE (SAÔNE-ET-LOIRE)
2014
Le site de Lux La Perrouze (Saône-et-Loire) apporte de nouvelles données sur le Campaniforme bourguignon par la découverte d’une petit ensemble céramique remarquablement homogène, contenu dans le remplissage de quatre structures en creux. Cet ensemble se compose essentiellement de céramique commune, mais quelques gobelets décorés sont également à signaler. L’étude de ce mobilier permet de souligner la remarquable homogénéité des productions du groupe campaniforme bourguignon-jurassien tant pour leur chronologie que pour leurs affinités culturelles. The site of Lux La Perrouze (Saône-et-Loire) has provided new data on the Bell Beaker culture of Burgundy by the discovery of a small and remark…
Effect of dual blockade of renin-angiotensin system on TGF beta 1 and left ventricular structure and function in hypertensive patients
2007
The effects of 24 weeks losartan and ramipril treatment,both alone and in combination, on left ventricular mass (LVM), circulating transforming growth factor b1(TGFb1), procollagen type I (PIP) and III (PIIIP), havebeen evaluated in hypertensive (HT) patients. A total of 57 HT with stage 1 and 2 essential hypertension were included. After 4 weeks run in, a randomized double blind, three arms, double dummy, independent trial was used. All HT patients were randomly allocated to three treatment arms consisting of losartan (50 mg/daily),ramipril (5 mg/ daily) and combined (losartan 50 mg/daily plus ramipril 5 mg/daily) for 24 weeks. TGFb1, PIP and PIIIP, LVM, LVM/h 2.7 and other echocardiograph…
Beta-Blocker Use in Older Hospitalized Patients Affected by Heart Failure and Chronic Obstructive Pulmonary Disease: An Italian Survey From the REPOS…
2022
Beta (β)-blockers (BB) are useful in reducing morbidity and mortality in patients with heart failure (HF) and concomitant chronic obstructive pulmonary disease (COPD). Nevertheless, the use of BBs could induce bronchoconstriction due to β2-blockade. For this reason, both the ESC and GOLD guidelines strongly suggest the use of selective β1-BB in patients with HF and COPD. However, low adherence to guidelines was observed in multiple clinical settings. The aim of the study was to investigate the BBs use in older patients affected by HF and COPD, recorded in the REPOSI register. Of 942 patients affected by HF, 47.1% were treated with BBs. The use of BBs was significantly lower in patients with…
Harmonic balance analysis of pull-in range and oscillatory behavior of third-order type 2 analog PLLs
2020
The most important design parameters of each phase-locked loop (PLL) are the local and global stability properties, and the pull-in range. To extend the pull-in range, engineers often use type 2 PLLs. However, the engineering design relies on approximations which prevent a full exploitation of the benefits of type 2 PLLs. Using an exact mathematical model and relying on a rigorous mathematical thinking this problem is revisited here and the stability and pull-in properties of the third-order type 2 analog PLLs are determined. Both the local and global stability conditions are derived. As a new idea, the harmonic balance method is used to derive the global stability conditions. That approach…