Search results for "Loi"
showing 10 items of 4617 documents
Atomistic Simulations of Functional Gold Nanoparticles Au144(Sr)60 Interacting with Membranes
2013
Gold nanoparticles (AuNps) are used in nanomedicine in, e.g., drug delivery and bio-imaging. However, it is regrettable that the understanding of nanoparticle properties in cellular surroundings is incompletely understood. Here, we have complemented our previous studies [1] by performing extensive atomistic molecular dynamics simulations of lipid membranes interacting with charged gold nanoparticles. We have elucidated the action of these nanoparticles on membranes characterized by lipid compositional asymmetry in the two leaflets, thereby unraveling the interactions of AuNPs with both the extracellular and the cytosolic sides of plasma membranes of eukaryotic cells. We have found that ther…
Biological Description of 109 Cases of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) from the French Network of BPDCN
2015
Abstract Blastic plasmacytoid dendritic cell neoplasm is a clonal disease derived from precursors of plasmacytoid dendritic cells (pDC). It is a rare neoplasm involving the skin which may or may not be associated from the outset with a leukemic component. The disease invariably progresses to aggressive leukemic dissemination, leading to a differential diagnosis with acute leukemia. In 2004, we set up a French network to recruit biological data at diagnosis. Diagnosis was according to recommendations (Swerdlow et al, 2008), with, in addition, a mandatory panel of pDC markers (Garnache-Ottou et al, 2009) detected by flow cytometry or by immunohistochemistry on infiltrated blood, bone marrow o…
Detecting Protein Aggregation on Cells Surface: Concanavalin A Oligomers Formation
2009
A number of neurodegenerative diseases involve protein aggregation and amyloid formation. Recently evidence has emerged indicating small-transient prefibrillar oligomers as the primary pathogenic agents. Noteworthy, strict analogies exist between the behaviour of cells in culture treated with misfolded non-pathogenic proteins and in pathologic conditions, this instance together with the observation that the oligomers and fibrils are characterised by common structural features suggest that common mechanisms for cytotoxicity could exists and have to be perused in common interactions involved in aggregation.We here report an experimental study on ConcanavalinA (ConA) aggregation and its effect…
Impact of Donor Type on Outcome after Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia Patients: Analysis of the German-Austrian Acute …
2014
Abstract Background:Despite recent advances in identifying novel molecular targets in AML patients, intensive chemotherapy followed by allogeneic hematopoietic stem cell transplantation (HSCT) still remains a cornerstone of AML therapy. However, outcome of HSCT depends on the availability of a donor and the donor type. Prior studies comparing HSCT from HLA-matched related donors (MRD) with matched unrelated donors (MUD), demonstrated conflicting results with regards to outcome. These conflicting results might be attributed to the genetic heterogeneity of AML. Aims:To analyze outcome with respect to donor type of 952 AML patients who received HSCT in first complete remission (CR) and were tr…
Does Linguistic Analysis Confirm the Validity of Facilitated Communication?
2016
Facilitated communication (FC) has been interpreted as an ideomotor phenomenon, in which one person physically supports another person’s hand and unconsciously affects the content of the writing. Despite the strong experimental evidence against the authenticity of FC output, several studies claim to support its validity based on idiosyncrasies found in the texts produced. A review of these studies showed that, because of the logical circularity of the reasoning proposed in the studies, no decisive evidence that validated FC was presented. In addition, the idiosyncrasies found were better explained as by-products of the unusual writing process itself. Finally, the studies did not fulfill th…
“Minding the gap” in the research on human trafficking for sexual purposes
2017
Since the signature of the United Nations Trafficking Protocol in December 2000 that human trafficking has been labelled as a transnational, complex criminal phenomenon. However, despite the implementation of international soft law instruments to tackle the phenomenon, human trafficking is constantly evolving by the frequent changes of strategies, routes, types of exploitation and methodologies applied by the criminal networks. This flexibility of the phenomenon does not only difficult the implementation of effective tackling measures, but it also demonstrates to be an obstacle to produce accurate information on the subject (Cusick et al, 2009). Furthermore, due to the hidden nature of the …
Deep neural attention-based model for the evaluation of italian sentences complexity
2020
In this paper, the Automatic Text Complexity Evaluation problem is modeled as a binary classification task tackled by a Neural Network based system. It exploits Recurrent Neural Units and the Attention mechanism to measure the complexity of sentences written in the Italian language. An accurate test phase has been carried out, and the system has been compared with state-of-art tools that tackle the same problem. The computed performances proof the model suitability to evaluate sentence complexity improving the results achieved by other state-of-the-art systems.
Extending PluTo for Multiple Devices by Integrating OpenACC
2018
For many years now, processor vendors increased the performance of their devices by adding more cores and wider vectorization units to their CPUs instead of scaling up the processors' clock frequency. Moreover, GPUs became popular for solving problems with even more parallel compute power. To exploit the full potential of modern compute devices, specific codes are necessary which are often coded in a hardware-specific manner. Usually, the codes for CPUs are not usable for GPUs and vice versa. The programming API OpenACC tries to close this gap by enabling one code-base to be suitable and optimized for many devices. Nevertheless, OpenACC is rarely used by `standard programmers' and while dif…
Stability of Asymmetric Lipid Bilayers Assessed by Molecular Dynamics Simulations
2009
The asymmetric insertion of amphiphiles into biological membranes compromises the balance between the inner and outer monolayers. As a result, area expansion of the receiving leaflet and curvature strain may lead to membrane permeation, shape changes, or membrane fusion events. We have conducted both atomistic and coarse-grained molecular dynamics simulations of dipalmitoyl-phosphatidylcholine (DPPC) bilayers to study the effect of an asymmetric distribution of lipids between the two monolayers on membrane stability. Highly asymmetric lipid bilayers were found to be surprisingly stable within the submicrosecond time span of the simulations. Even the limiting case of a monolayer immersed in …
Short X···N Halogen Bonds With Hexamethylenetetraamine as the Acceptor
2021
Hexamethylenetetramine (HMTA) and N-haloimides form two types of short (imide)X···N and X–X···N (X = Br, I) halogen bonds. Nucleophilic substitution or ligand-exchange reaction on the peripheral X of X–X···N with the chloride of N-chlorosuccinimide lead to Cl–X···N halogen-bonded complexes. The 1:1 complexation of HMTA and ICl manifests the shortest I···N halogen bond [2.272(5) Å] yet reported for an HMTA acceptor. Two halogen-bonded organic frameworks are prepared using 1:4 molar ratio of HMTA and N-bromosuccinimide, each with a distinct channel shape, one possessing oval and the other square grid. The variations in channel shapes are due to tridentate and tetradentate (imide)Br···N coordi…