Search results for "Loin"
showing 10 items of 294 documents
Neural Adaptations to Strength Training
2018
Scientific study of strength training has revealed numerous physiological mechanisms that contribute to: (1) acute fatigue from a single strength training session and (2) chronic adaptation to repetitive and systematic strength training. Therefore, the purpose of this chapter is initially to discuss potential neural mechanisms that influence force production from the perspective of a single repetition. Thereafter, the chapter will highlight scientific evidence for candidate neural mechanisms that acutely limit force production during a single strength training session and long-term adaptations caused by strength training. For some of these potential neural mechanisms, there is strong scient…
Technical note : Simulation of lung counting applications using Geant4
2023
A Geant4 simulation package has been developed to investigate and test detector configurations for lung counting applications. The objective of this study was to measure radiation emitted from the human body and to make a qualitative comparison of the results of the simulation with an experiment. Experimental data were measured from a plastic phantom with a set of lungs containing 241Am activity. For comparison, simulations in which 241Am activity was uniformly distributed inside the lungs of the ICRP adult reference computational phantom were made. The attenuation of photons by the chest wall was simulated and from this photopeak ef-ficiency and photon transmission were calculated as a fun…
Pre-service teachers and guided inquiry-based science teaching with simulations
2017
The aim of this dissertation was explore the beliefs and practices of pre-service primary teachers on using simulations as a part of guided inquiry-based lessons. Even though research has shown that using simulations to learn science offers certain learning benefits compared to other forms of instruction, their use in Finnish schools is still rare compared to the international average. Teacher training has the potential to promote the use of simulations in primary classrooms. Internationally, research has been called for the role of teachers in learning and teaching with simulations. As a part of this dissertation, an intervention was designed to accustom a group of pre-service teachers to …
Best Practices in Constant pH MD Simulations: Accuracy and Sampling
2022
Various approaches have been proposed to include the effect of pH in molecular dynamics (MD) simulations. Among these, the λ-dynamics approach proposed by Brooks and co-workers [Kong, X.; Brooks III, C. L. J. Chem. Phys.1996, 105, 2414−2423] can be performed with little computational overhead and hfor each typeence be used to routinely perform MD simulations at microsecond time scales, as shown in the accompanying paper [Aho, N. et al. J. Chem. Theory Comput.2022, DOI: 10.1021/acs.jctc.2c00516]. At such time scales, however, the accuracy of the molecular mechanics force field and the parametrization becomes critical. Here, we address these issues and provide the community with guidelines on…
Developing and testing a discrete event simulation model to evaluate budget impacts of diabetes prevention programs
2020
Type 2 diabetes (T2D) is one of the most rapidly increasing non-communicable diseases worldwide. Lifestyle interventions are effective in preventing T2D but also resource intensive. This study evaluated with discrete event simulation (DES) the relative budget impacts of three hypothetical diabetes prevention programs (DPP), including group-based contact intervention, digital program with human coaching and fully automated program. The data for simulation were derived from research literature and national health and population statistics. The model was constructed using the iGrafx Process for Six Sigma software and simulations were carried out for 10 years. All simulated interventions produc…
Modeling the atomic and electronic structure of nanoparticle-ligand interfaces
2013
New Capabilities of the FLUKA Multi-Purpose Code
2022
We would like to deeply thank the CERN Knowledge Transfer and Legal Service teams for their essential and extended support. Our appreciation also goes to the FLUKA.CERN Collaboration Board members for their strong commitment.
Understanding altered contractile properties in advanced age : insights from a systematic muscle modelling approach
2023
Age-related alterations of skeletal muscle are numerous and present inconsistently, and the effect of their interaction on contractile performance can be nonintuitive. Hill-type muscle models predict muscle force according to well-characterised contractile phenomena. Coupled with simple, yet reasonably realistic activation dynamics, such models consist of parameters that are meaningfully linked to fundamental aspects of muscle excitation and contraction. We aimed to illustrate the utility of a muscle model for elucidating relevant mechanisms and predicting changes in output by simulating the individual and combined effects on isometric force of several known ageing-related adaptations. Simu…
Luurankolihassolun glykolyysin simulointi differentiaaliyhtälöillä
2015
Solun aineenvaihduntaa on hankala tutkia. Simulointi voi olla eräs ratkaisu ongelmaan. Tutkielma tarkastelee differentiaaliyhtälöihin perustuvaa luurankolihaksen glykolyysin simuloimista. Siihen on kehitetty 2000-luvulla glykolyysin reaktioiden empiirisiin mittaustuloksiin perustuvia malleja. Differentiaaliyhtälömallit soveltuvat hyvin simuloimiseen, ja suurinpana ongelmana voidaan pitää parametrien saatavuutta ja epävarmuutta. Cell metabolism is difficult to investigate. Simulation can be one solution to the problem. This thesis examines differential equation based simulation of skeletal muscle glycolysis. For simulation, in 2000s it has been developed models based on empirical measurement…