Search results for "Loin"
showing 10 items of 294 documents
Improved Frequentist Prediction Intervals for Autoregressive Models by Simulation
2015
It is well known that the so called plug-in prediction intervals for autoregressive processes, with Gaussian disturbances, are too narrow, i.e. the coverage probabilities fall below the nominal ones. However, simulation experiments show that the formulas borrowed from the ordinary linear regression theory yield one-step prediction intervals, which have coverage probabilities very close to what is claimed. From a Bayesian point of view the resulting intervals are posterior predictive intervals when uniform priors are assumed for both autoregressive coefficients and logarithm of the disturbance variance. This finding opens the path how to treat multi-step prediction intervals which are obtain…
A ceRNA approach may unveil unexpected contributors to deletion syndromes, the model of 5q- syndrome.
2015
In genomic deletions, gene haploinsufficiency might directly configure a specific disease phenotype. Nevertheless, in some cases no functional association can be identified between haploinsufficient genes and the deletion-associated phenotype. Transcripts can act as microRNA sponges. The reduction of transcripts from the hemizygous region may increase the availability of specific microRNAs, which in turn may exert in-trans regulation of target genes outside the deleted region, eventually contributing to the phenotype. Here we prospect a competing endogenous RNA (ceRNA) approach for the identification of candidate genes target of epigenetic regulation in deletion syndromes. As a model, we an…
Putative Breast Cancer Driver Mutations in TBX3 Cause Impaired Transcriptional Repression
2015
The closely related T-box transcription factors TBX2 and TBX3 are frequently overexpressed in melanoma and various types of human cancers, in particular, breast cancer. The overexpression of TBX2 and TBX3 can have several cellular effects, among them suppression of senescence, promotion of epithelial–mesenchymal transition, and invasive cell motility. In contrast, loss of function of TBX3 and most other human T-box genes causes developmental haploinsufficiency syndromes. Stephens and colleagues (1), by exome sequencing of breast tumor samples, identified five different mutations in TBX3, all affecting the DNA-binding T-domain. One in-frame deletion of a single amino acid, p.N212delN, was ob…
4p16.1-p15.31 duplication and 4p terminal deletion in a 3-years old Chinese girl: Array-CGH, genotype-phenotype and neurological characterization
2014
Abstract Background Microscopically chromosome rearrangements of the short arm of chromosome 4 include the two known clinical entities: partial trisomy 4p and deletions of the Wolf-Hirschhorn critical regions 1 and 2 (WHSCR-1 and WHSCR-2, respectively), which cause cranio-facial anomalies, congenital malformations and developmental delay/intellectual disability. Methods/results We report on clinical findings detected in a Chinese patient with a de novo 4p16.1-p15.32 duplication in association with a subtle 4p terminal deletion of 6 Mb in size. This unusual chromosome imbalance resulted in WHS classical phenotype, while clinical manifestations of 4p trisomy were practically absent. Conclusio…
Valvontakapitalismin ensimmäiset vuosikymmenet
2021
Arvio teoksesta: Zuboff, Shoshana. 2019. The Age of Surveillance Capitalism: The Fight for the Future at the New Frontier of Power. Lontoo: Profile Books, 704 s.
A heuristic model-based approach for compensating wind effects in ski jumping.
2021
Wind influences the jump length in ski jumping, which raises questions about the fairness. To counteract the wind problem, the International Ski Federation has introduced a wind compensation system in 2009: time-averaged wind velocity components tangential to the landing slope are obtained from several sites along the landing slope, and these data are used in a linear statistical model for estimating the jump length effect of wind. This is considered in the total score of the ski jump. However, it has been shown that the jump length effect estimates can be inaccurate and misleading. The present manuscript introduces an alternative mathematical wind compensation approach that is based on an …
Pythia 8 as hadronic interaction model in air shower simulations
2023
Hadronic interaction models are a core ingredient of simulations of extensive air showers and pose the major source of uncertainties of predictions of air shower observables. Recently, Pythia~8, a hadronic interaction model popular in accelerator-based high-energy physics, became usable in air shower simulations as well. We have integrated Pythia~8 with its new capabilities into the air shower simulation framework CORSIKA~8. First results show significantly shallower shower development, which we attribute to higher cross-section predictions by the new simplified nuclear model of Pythia.
Täpläravun (Pacifastacus leniusculus) vaikutus ahventen (Perca fluviatilis) loisyhteisöihin Päijänteellä
2010
Täplärapu (Pacifastacus leniusculus) on tulokaslaji Suomen vesistöissä. Sen on käyttäytymisellään ja ravinnonkäytöllään todettu vähentävän elinalueidensa eliöyhteisöjen monimuotoisuutta. Esimerkiksi Päijänteellä on havaittu joidenkin pohjaeläinten kuten kotiloiden tiheyksien olevan alhaisempia ravun elinalueilla kuin ravuttomilla alueilla. Pohjaselkärangattomat ovat välttämättömiä väli-isäntiä monelle kalan loiselle. Tässä tutkimuksessa selvitettiin, millaisia muutoksia täplärapu voi välillisesti aiheuttaa kalojen loisyhteisöissä muuttamalla pohjaeläinten runsautta. Päijänteeltä valittiin viisi toisistaan riippumatonta ravullista ja ravutonta aluetta. Jokaiselta alueelta pyydettiin mahdolli…
Virtual Enterprise Simulation Game as an Environment for Collaborative Creativity and Learning
2021
AbstractWhen employees become accustomed to everyday working habits it can prevent them from generating creative ideas. This familiarity takes the forms of mainly collaborating with familiar colleagues, playing roles that develop over years, and solving encountered problems with proven strategies. This chapter considers how a virtual enterprise simulation game (RealGame) can potentially foster digital creativity and collaborative learning. The game simulates a situation where team members take responsibility for managing a virtual manufacturing company and its supply chain. Theoretically, we consider RealGame a facilitating environment for people to collaborate by offering a safe environmen…
New Insights into Potocki-Shaffer Syndrome: Report of Two Novel Cases and Literature Review
2020
Potocki-Shaffer syndrome (PSS) is a rare non-recurrent contiguous gene deletion syndrome involving chromosome 11p11.2. Current literature implies a minimal region with haploinsufficiency of three genes, ALX4 (parietal foramina), EXT2 (multiple exostoses), and PHF21A (craniofacial anomalies, and intellectual disability). The rest of the PSS phenotype is still not associated with a specific gene. We report a systematic review of the literature and included two novel cases. Because deletions are highly variable in size, we defined three groups of patients considering the PSS-genes involved. We found 23 full PSS cases (ALX4, EXT2, and PHF21A), 14 cases with EXT2-ALX4, and three with PHF21A only…