Search results for "Long-Term"

Wie wirksam sind analytische und tiefenpsychologisch fundierte Langzeitpsychotherapien bei Jugendlichen?

2011

Fragestellung: In der Qualitätssicherung der analytischen Psychotherapie bei Kindern und Jugendlichen fehlen bislang Studien, die die Effizienz aus der Sicht unterschiedlicher, an der Behandlung beteiligter Personen erheben. Methodik: In 28 Langzeitpsychotherapien bei Jugendlichen wurde die Effizienz der Behandlung aus der Sicht von Jugendlichen, ihren Eltern sowie ihren Therapeuten über drei Messzeitpunkte in einem Zeitraum von durchschnittlich 113 Stunden untersucht. Ergebnisse: Die Therapiegruppe (n = 28) unterschied sich von einer unbehandelten Wartekontrollgruppe (n = 32) nicht in wesentliche Stichprobenmerkmalen; auch das Diagnosespektrum war gleich. Die Therapeuten berichteten eine …

Relational long-term breastfeeding

2021

This article uses a relationality-sensitive perspective to analyse long-term breastfeeding. The data was gathered through open invitations to write, and the article is based on the written reflections of 39 long-term breastfeeding Finnish mothers. In Finland, the breastfeeding of babies is strongly supported, but long-term breastfeeding (over 12 months) is a more conflicted issue, and the cultural norm of one year of breastfeeding is strong. Through qualitative content analysis, the article shows how mothers reflect on long-term breastfeeding’s effects on their relations with their breastfed children, partners (if any), relatives and healthcare professionals. The findings show that long-ter…

Psychophysical burden and lack of support : Reasons for care workers’ intentions to leave their work in the Nordic countries

2021

Long-term care of older adults is currently suffering from a shortage of trained personnel and high turnover rates. Care work is poorly paid, demanding, increasingly time-bound and both mentally and physically burdensome. In this study, we examined the individual, organisational and economic factors that predict professional care workers’ intentions to leave their current employment, using the NORDCARE survey data (2015, N = 3801) collected in Denmark, Finland, Norway and Sweden. The respondents were mainly practical and assistant nurses. The analysis showed that the predictors of intentions to leave were similar in the four countries. The most consistent organisational predictors of leavin…

Ikä, identiteetti ja ohjaava koulutus. Ikääntyvät pitkäaikaistyöttömät oppimisyhteiskunnan haasteena

2007

Piia Silvennoinen tutki väitöskirjassaan, millainen merkitys työvoimapoliittisella koulutuksella on ikääntyvien pitkäaikaistyöttömien elämässä. Koulutusten oletetaan parantavan ikääntyvien pitkäaikaistyöttömien työmarkkinakelpoisuutta ja elämänhallintaa. Silvennoinen haki vastausta siihen, miten ikääntyvät pitkäaikaistyöttömät itse suhtautuvat työvoimapoliittisiin koulutuksiin; onko niistä heille haittaa vai hyötyä. Silvennoinen kertoo, että koulutuksen hyödyllisyyttä arvioidaan sen työllistävän vaikutuksen kautta. – Mitä vähemmän koulutus työllistää, sitä enemmän myös sen muut merkitykset menettävät arvoaan ikääntyvien pitkäaikaistyöttömien elämässä, Silvennoinen toteaa. Nykyinen itseohjau…

Hsp60 Protects against Amyloid β Oligomer Synaptic Toxicity via Modification of Toxic Oligomer Conformation

2019

Alzheimer's disease (AD) is the leading cause of dementia worldwide. While the etiology of AD remains uncertain, neurotoxic effects of amyloid beta oligomers (Aβo) on synaptic function, a well-established early event in AD, is an attractive area for the development of novel strategies to modify or cease the disease's progression. In this work, we tested the protective action of the mitochondrial chaperone Hsp60 against Aβo neurotoxicity, by determining the direct effect of Hsp60 in changing Aβo toxic conformations and thus reducing their dysfunctional synaptic binding and consequent suppression of long-term potentiation. Our data suggest that Hsp60 has a direct impact on Aβo, resulting in a…

Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer’s disease: three partners in cr…

2011

All three cholesterol oxidation products implicated thus far in the pathogenesis of Alzheimer's disease, 7β-hydroxycholesterol, 24-hydroxycholesterol, and 27-hydroxycholesterol, markedly enhance the binding of amyloid-beta (Aβ) to human differentiated neuronal cell lines (SK-N-BE and NT-2) by up-regulating net expression and synthesis of CD36 and β1-integrin receptors. However, only 24-hydroxycholesterol markedly potentiates the pro-apoptotic and pro-necrogenic effects of Aβ(1-42) peptide on these cells: 7β-hydroxycholesterol and 27-hydroxycholesterol, like unoxidized cholesterol, show no potentiating effect. This peculiar behavior of 24-hydroxycholesterol at physiologic concentrations (1 μ…

A Kinetic Model of Short- and Long-Term Potentiation

1993

We present a kinetic model that can account for several experimental findings on short- and long-term potentiation (STP and LTP) and their pharmacological modulation. The model, which is consistent with Hebb's postulate, uses the hypothesis that part of the origin of LTP may be a consequence of an increased release of neurotransmitter due to a retrograde signal. The operation of the model is expressed by a set of irreversible reactions, each of which should be thought of as equivalent to a set of more complex reactions. We show that a retrograde signal alone is not sufficient to maintain LTP unless long-term change of the rate constant of some of the reactions is caused by high-frequency s…

2013

Nitric oxide, produced by the neuronal nitric oxide synthase (nNOS) from L-arginine is an important second messenger molecule in the central nervous system: It influences the synthesis and release of neurotransmitters and plays an important role in long-term potentiation, long-term depression and neuroendocrine secretion. However, under certain pathological conditions such as Alzheimer’s or Parkinson’s disease, stroke and multiple sclerosis, excessive NO production can lead to tissue damage. It is thus desirable to control NO production in these situations. So far, little is known about the substrate supply to human nNOS as a determinant of its activity. Measuring bioactive NO via cGMP form…

Long-Term Efficacy of Psychosocial Treatments for Adults With Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Review

2018

Background: Recent evidence suggests that psychosocial treatments, particularly cognitive-behavioral therapy (CBT), are effective interventions for adult attention deficit hyperactivity disorder (ADHD). The objective of this review was to determine the long-term efficacy of psychosocial interventions in improving clinically relevant variables, including ADHD core symptoms, clinical global impression (CGI), and global functioning. Methods: In total, nine randomized controlled trials and three uncontrolled single-group pretest-posttest studies were included. The data from these studies were combined using the inverse variance method. Heterogeneity and risk of bias were assessed. Subgroup anal…

Advanced Composites and Applications: Book of abstracts

2023

The section ‘Advanced Composites and Applications’ was organized by the Institute for Mechanics of Materials of the University of Latvia (LU MMI) on 16.02.2023 as a part of the annual 81th scientific conference of the University of Latvia. It was organized remotely in Zoom. The official language of the section was English. The duration of the presentation was 10 minutes. The section was devoted to the discussion of the recent results within following topics: structure and properties of polymers and polymer-based composites, long-term properties, creep, and environmental ageing, composites for advanced applications, mechanical aspects of technology, and multifunctional properties.