Search results for "Long-lasting"
showing 9 items of 9 documents
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to reveal 5-HT1A receptor function
2003
Central GABAergic and serotoninergic systems interact with one another and are implicated in controlling different behaviours. A gentle early long-lasting handling can prevent the deficits in locomotion and exploration in open field (O.F.) in 3-month-old male rats prenatally exposed to diazepam (DZ). Purpose of this study was to extend the research to older handled rats prenatally exposed to DZ and to assess the activity of 5-HT1A receptors (Rs), evaluating the performance in O.F. at 3 and 18 months of age following 8-OH-DPAT administration. A single daily s.c. injection of DZ (1.5 mg/kg) from gestation day 14 to gestation day 20 induced in aged, but not in young rats, a decrease in total d…
The antidepressant-like effect of tDCS in mice: A behavioral and neurobiological characterization
2017
Abtract Background Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. Objective The present study aims to (i) determine the most effective stimulation parameters to optimize antidepressant-like effect of tDCS in the forced-swim test in mice and (ii) identify brain regions recruited by tDCS and possibly involved in its behavioral effect using Fos immunohistochemistry. Results We reported that tDCS induced long-lasting antidepressant-like ef…
Long-lasting remission of primary hepatic lymphoma and hepatitis C virus infection achieved by the alpha-interferon treatment
2004
Primary hepatic lymphoma is a rare but well-defined lymphoma entity that often pursues an aggressive clinical course. Most cases have been described in hepatitis C virus (HCV)-related chronic liver disease patients. Although anthracycline-based chemotherapy has been reported to be highly effective, the best therapeutic strategy has not been defined yet. The prognosis is dismal especially in patients treated with chemotherapy alone or when an advanced liver disease is present. Herein, we describe a case of primary hepatic large B-cell non-Hodgkin’s lymphoma, in a patient with HCV chronic infection. After a minor response with eight cycles of CHOP chemotherapy, a complete and sustained remiss…
Temporal patterns in immune responses to a range of microbial insults (Tenebrio molitor).
2008
8 pages; International audience; Much work has elucidated the pathways and mechanisms involved in the production of insect immune effector systems. However, the temporal nature of these responses with respect to different immune insults is less well understood. This study investigated the magnitude and temporal variation in phenoloxidase and antimicrobial activity in the mealworm beetle Tenebrio molitor in response to a number of different synthetic and real immune elicitors. We found that antimicrobial activity in haemolymph increased rapidly during the first 48h after a challenge and was maintained at high levels for at least 14 days. There was no difference in the magnitude of responses …
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to rveal 5-HT1a receptor function
2003
Central GABAergic and serotoninergic systems interact with one another and are implicated in controlling different behaviours. A gentle early long-lasting handling can prevent the deficits in locomotion and exploration in open field (O.F.) in 3-month-old male rats prenatally exposed to diazepam (DZ). Purpose of this study was to extend the research to older handled rats prenatally exposed to DZ and to assess the activity of 5-HT1A receptors (Rs), evaluating the performance in O.F. at 3 and 18 months of age following 8-OH-DPAT administration. A single daily s.c. injection of DZ (1.5 mg/kg) from gestation day 14 to gestation day 20 induced in aged, but not in young rats, a decrease in total d…
Proposed use of spatial mortality assessments as part of the pesticide evaluation scheme for vector control
2013
Background: The WHO Pesticide Evaluation Scheme to evaluate the efficacy of insecticides does not include the testing of a lethal effect at a distance. A tool was developed to evaluate the spatial mortality of an insecticide product against adult mosquitoes at a distance under laboratory and field conditions. Operational implications are discussed. Methods: Insecticide paint, Inesfly 5A IGR (TM), containing two organophosphates (OPs): chlorpyrifos and diazinon, and one insect growth regulator (IGR): pyriproxyfen, was the product tested. Laboratory tests were performed using "distance boxes" with surfaces treated with one layer of control or insecticide paint at a dose of 1 kg/6 sq m. Field …
Evaluation of the efficacy of a new insecticide paint against malaria vectors
2015
La malaria continúa siendo un problema de salud pública global. Se calcula que en el mundo hay 3.300 millones de personas en 97 países y territorios que corren el riesgo de padecer el paludismo, y que para 1.200 millones ese riesgo es elevado (WHO, 2014). El control de la malaria a gran escala está altamente basado en al control del vector, principalmente mediante el uso de mosquiteras tratadas con insecticidas de larga duración (LLINs), y en menor medida, el Rociamiento Residual Intradomiciliario. Todos los tratamientos recomendados de LLINs y la mayoría del Rociamiento Residual Intradomiciliario se basan en el uso de piretroides. La creciente resistencia de los vectores de malaria a los p…
Shortwave Ultraviolet Persistent Luminescence of Sr2MgSi2O7: Pr3+
2023
Currently, extensive research activities are devoted to developing persistent phosphors which extend beyond the visible range. In some emerging applications, long-lasting emission of high-energy photons is required; however, suitable materials for the shortwave ultraviolet (UV–C) band are extremely limited. This study reports a novel Sr2MgSi2O7 phosphor doped with Pr3+ ions, which exhibits UV–C persistent luminescence with maximum intensity at 243 nm. The solubility of Pr3+ in the matrix is analysed by X-ray diffraction (XRD) and optimal activator concentration is determined. Optical and structural properties are characterised by photoluminescence (PL), thermally stimulated lumi…