Search results for "Loo"

A pyrroloquinazoline derivative with anti-inflammatory and analgesic activity by dual inhibition of cyclo-oxygenase-2 and 5-lipoxygenase

2002

Abstract In a previous study, we reported a new pyrroloquinazoline derivative, 3-(4′-acetoxy-3′,5′-dimethoxy)benzylidene-1,2-dihydropyrrolo[2,1- b ]quinazoline-9-one (PQ), which inhibited human purified 5-lipoxygenase activity and prostaglandin E 2 release in lipopolysaccharide-stimulated RAW 264.7 cells. In the present work, we show that PQ inhibits cyclo-oxygenase-2 activity in intact cell assays (human monocytes) and purified enzyme preparations (ovine isoenzymes) without affecting cyclo-oxygenase-1 activity. This behaviour was confirmed in vivo by using the zymosan-injected mouse air pouch model, where PQ caused a marked reduction in cell migration and leukotriene B 4 levels at 4 h, as …

Spontaneous labour at term is associated with fetal monocyte activation.

1999

SUMMARYThe aetiology of both term and preterm labour remains incompletely understood. Maternal infectious diseases as well as intra-uterine infections were shown to be a well established cause of uncontrollable preterm delivery, indicating that inflammatory reactions, regulated by maternal immunecompetent cells, are implicated in labour-promoting mechanisms. To investigate the possibility that the activation of the fetal immune system may be involved in labour induction, we examined cytokine production patterns of different cord blood cell populations obtained from neonates after spontaneous onset of normal term labour and vaginal delivery (n = 25), vaginal delivery but induced term labour …

Evaluation of the Oxiris Membrane in Cardiogenic Shock Requiring Extracorporeal Membrane Oxygenation Support: Study Protocol for a Single Center, Sin…

2021

Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is the rescue treatment proposed to patients with refractory cardiogenic shock. The VA-ECMO implantation promotes inflammation and ischemia-reperfusion injuries through the VA-ECMO flow, causing digestive mucosa barrier disrupture and inducing translocation of bacterial wall components—Lipopolysaccharides (LPS) with further inflammation and circulatory impairment. LPS is a well-studied surrogate indicator of bacterial translocation. Oxiris membrane is a promising and well-tolerated device that can specifically remove LPS. The main study aim is to compare the LPS elimination capacity of Oxiris membrane vs. a non-absorban…

Percorrendo il Bestiario. La rappresentazione del mondo animale nei pavimenti musivi del Medioevo veneziano

2019

Kadmiumaltistuksen havaitseminen Hydropsyche pellucidula -vesiperhostoukilla (Trichoptera: Hydropsychidae) hyperspektrikuvantamisen ja kidusvaurioide…

2017

Metallipäästöt aiheuttavat vesistöissä eliöyhteisöille monenlaisia haittavaikutuksia, joita voidaan tutkia bioindikaattori- eli ilmentäjälajimenetelmin. Vesiperhostoukkia (Trichoptera) on käytetty virtavesien metallisaastumisen indikaattoreina, sillä ne kestävät metallialtistusta suhteellisen hyvin, mutta altistuksen seurauksena toukilla voi esiintyä morfologisia muutoksia, kuten kidusvaurioita tai pintakudoksen tummumista. Koska toisaalta vierasaineiden kudospitoisuusmittaus on usein työlästä ja toisaalta rakenteellisten muutosten arviointi altis subjektiiviselle harhalle, tavoitteenani oli kehittää objektiivinen ja kustannustehokas tapa selvittää metallialtistusta ja sen vaikutuksia pohja…

Merimiesten vaimot, naisten toimijuus ja perheiden toimeentuloehdot 1800-luvun suomalaisessa rannikkokaupungissa

2016

Relationships between metabolic syndrome and steady and pulsatile components of clinic and 24-h blood pressure

2006

Infective Endocarditis: Preliminary Results of a Cohort Study in the Southern Italian Population.

2020

Background Infective endocarditis (IE) is an uncommon disease with an involved interplay of clinical and surgical team management. We aimed to define diagnosis parameters and delineate in-hospital management in patients with IE admitted in a tertiary hospital of Southern Italian. Materials and methods Fifty-six consecutive patients (42 males, 14 females; age range: 34-85 years) admitted for IE in the Infectious Diseases, Cardiac Surgery, and Cardiology units, between January 2011 and August 2017, were enrolled. Demographic data, mortality, comorbidities, specimen type, microscopy results, special histological staining performed, and antimicrobial therapy were collected and analyzed. Any com…

Acceptance-, mindfulness- and value-based psychological coaching for elite female floorball players

2014

Continuous subcutaneous Insulin infusion leads to immediate, table, and long-term changes in metabolic control

2008

Background:  Evaluations of continuous subcutaneous insulin infusion (CSII) usually focus on one pre- and one post-CSII measurement to assess metabolic therapy outcome. Aim:  Extending this research, the aim of the present study was to provide a more fine-grained analysis of achieved glycaemic control. Methods:  In 52 patients with type 1 diabetes (mean age of 37.85 years at CSII begin; s.d. ± 12.41), haemoglobin A1c (HbA1c) levels were assessed every 3 months over a period of 5 years (1 year before and 4 years after the introduction of CSII). Mixed models were utilized to describe changes in glycaemic control. Results:  The pre–post course showed that already in the first quarter, a statis…