Search results for "Lope"

Bone mineral density and bone turnover in Romanian children and young adults with classical 21-hydroxylase deficiency are influenced by glucocorticoi…

2009

Summary Objective  It remains controversial if glucocorticoid replacement therapy impairs bone mineral density (BMD) in young patients with 21-hydroxylase deficiency. We aimed to analyze the impact of treatment variables, phenotype and genotype on BMD and bone metabolism in these patients. Design  Cross-sectional study. Measurements  Twenty-eight Caucasian patients with classical 21-hydroxylase deficiency (5–39 years). Clinical parameters, hormonal status, osteocalcin (OC), C-terminal telopeptide of type I collagen (CTX), genotype and lumbar BMD (Z-scores) were assessed. Cumulative and mean hydrocortisone equivalent doses were calculated for the entire treatment period. Results  Patients wi…

Coherence between brain activation and speech envelope at word and sentence levels showed age-related differences in low frequency bands

2021

Abstract Speech perception is dynamic and shows changes across development. In parallel, functional differences in brain development over time have been well documented and these differences may interact with changes in speech perception during infancy and childhood. Further, there is evidence that the two hemispheres contribute unequally to speech segmentation at the sentence and phonemic levels. To disentangle those contributions, we studied the cortical tracking of various sized units of speech that are crucial for spoken language processing in children (4.7–9.3 years old, N = 34) and adults (N = 19). We measured participants’ magnetoencephalogram (MEG) responses to syllables, words, and…

Adaptive Function and Brain Evolution

2012

Comparing brains is not a mere intellectual exercise but also helps to understand how the brain enables adaptive behavioral strategies to cope with an ever-changing world and how this complex organ has evolved during the phylogeny. For instance, comparative neurobiology helps understanding the specific features of our species, an issue that attracted scientists since the time of Santiago Ramon y Cajal. Following this tradition, 20 years ago Hans ten Donkelaar and Gerhard Roth started the European Conferences on Comparative Neurobiology (ECCN). This e-book includes some of the contributions to the last meeting, the sixth ECCN (Valencia, Spain; April 22-24 2010), plus selected works by severa…

ARCHITECTURE AND PHOTOVOLTAICS. Strategies, technologies and novel components for the building envelope

Il principale obiettivo della tesi ha riguardato lo studio di strategie e tecnologie per l’integrazione del fotovoltaico negli edifici, con particolare attenzione verso le tecnologie solari di terza generazione, e la successiva definizione di un componente multifunzionale innovativo per l’involucro edilizio integrato con Dye-sensitized Solar Cells (DSC). Nella prima parte del lavoro, la ricerca si è concentrata sull’analisi del mercato del Building Integrated Photovoltaics (BIPV), sottolineando differenze, limiti e potenzialità di ciascuna tecnologia fotovoltaica. Particolare attenzione, inoltre, è stata rivolta a un numero consistente di casi studio, ossia edifici di nuova costruzione o in…

TOWARDS A TAO BUILDING’S ENVELOPE: THE IMPORTANCE OF THE VOID

2017

The forward summarizes the role of the void in the building envelope.

Benefits of a translucent building envelope made of DSC-integrated glass blocks

2015

The aim of this paper is to analyse the benefits deriving from the replacement of the glazed façades of an office building located in Palermo (Sicily) with a new translucent BIPV envelope made of multifunctional glass block panels integrated with Dye-sensitized Solar Cells (DSCs). The analysed 11-storey building is cladded by a curtain wall determining high management costs, especially during summer, in order to maintain indoor comfort. After the design of the building envelope and of the components for the connection of the glass block panels with existing load bearing structure, the energy performance of the building, before and after the replacement of its envelope, were analysed with th…

T-cell receptor transfer into human T cells with ecotropic retroviral vectors

2014

Adoptive T-cell transfer for cancer immunotherapy requires genetic modification of T cells with recombinant T-cell receptors (TCRs). Amphotropic retroviral vectors (RVs) used for TCR transduction for this purpose are considered safe in principle. Despite this, TCR-coding and packaging vectors could theoretically recombine to produce replication competent vectors (RCVs), and transduced T-cell preparations must be proven free of RCV. To eliminate the need for RCV testing, we transduced human T cells with ecotropic RVs so potential RCV would be non-infectious for human cells. We show that transfection of synthetic messenger RNA encoding murine cationic amino-acid transporter 1 (mCAT-1), the re…

Primeras consideraciones en torno a la preparación de un proyecto de enciclopedia de ciencias del hombre y de la sociedad

1983

Préparation d'un projet d'encyclopédie des sciences de l'homme et de la société: premières considérations

1983

Pulse EPR methods for studying chemical and biological samples containing transition metals

2006

This review discusses the application of pulse EPR to the characterization of disordered systems, with an emphasis on samples containing transition metals. Electron nuclear double-resonance (ENDOR), electron-spin-echo envelope-modulation (ESEEM), and double electron-electron resonance (DEER) methodologies are outlined. The theory of field modulation is outlined, and its application is illustrated with DEER experiments. The simulation of powder spectra in EPR is discussed, and strategies for optimization are given. The implementation of this armory of techniques is demonstrated on a rich variety of chemical systems: several porphyrin derivatives that are found in proteins and used as model s…