Search results for "Lope"

The city on the Moldau as a liminal space: Prague in Anthony Trollope's "Nina Balatka"

2022

The article discusses Anthony Trollope's representation of the city of Prague in his 1867 novel Nina Balatka, which first appeared anonymously in the Blackwood's Magazine. The novel tells the story of the eponymous protagonist, a Christian woman, who falls in love with a Jewish man. Trollope's choice of Prague as the backdrop for the story of two lovers separated by the great gulf between Christians and Jews seems particularly fitting, because the spatial division of the city by the river Moldau which separates the Christian and the Jewish parts of town reinforces the sense that the two protagonists come from different worlds. Trollope's characters exist in the realistically represented cit…

Effect of some hexahydroimidazo[1,2-c]pyrimidines in inflammatory responses involving leucocytes and macrophages.

2001

Abstract We have studied the effects of some hexahydroimidazo[1,2-c]pyrimidine derivatives (HIPs) on leucocyte functions in-vitro and we have assayed the anti-inflammatory activity of these compounds in two models of inflammation. All HIPs inhibited the human neutrophil degranulation process and superoxide generation at concentrations in the μM range. In mouse peritoneal macrophages stimulated with lipopolysaccharide, HIP-4 and HIP-5 inhibited nitrite production without affecting prostaglandin E2 (PGE2) accumulation. HIP-4 was also active in the zymosan-injected mouse air pouch model (at 100 nmol/pouch), with significant reductions in leucocyte migration and PGE2 and leukotriene B4 levels i…

First Evidence for a Covalent Linkage between Enterobacterial Common Antigen and Lipopolysaccharide in Shigella sonnei Phase II ECALPS

2014

Enterobacterial common antigen (ECA) is expressed by Gram-negative bacteria belonging to Enterobacteriaceae, including emerging drug-resistant pathogens such as Escherichia coli, Klebsiella pneumoniae, and Proteus spp. Recent studies have indicated the importance of ECA for cell envelope integrity, flagellum expression, and resistance of enteric bacteria to acetic acid and bile salts. ECA, a heteropolysaccharide built from the trisaccharide repeating unit, →3)-α-D-Fucp4NAc-(1→4)-β-D-ManpNAcA-(1→4)-α-D-GlcpNAc-(1→, occurs as a cyclic form (ECA(CYC)), a phosphatidylglycerol (PG)-linked form (ECA(PG)), and an endotoxin/lipopolysaccharide (LPS)-associated form (ECA(LPS)). Since the discovery of…

Ciona intestinalis peroxinectin is a novel component of the peroxidase–cyclooxygenase gene superfamily upregulated by LPS

2013

Peroxinectins function as hemoperoxidase and cell adhesion factor involved in invertebrate immune reaction. In this study, the ascidian (Ciona intestinalis) peroxinectin gene (CiPxt) and its expression during the inflammatory response have been examined. CiPxt is a new member of the peroxidase-cyclooxygenase gene superfamily that contains both the peroxidase domain and the integrin KGD (Lys-Gly-Asp) binding motif. A phylogenetic tree showed that CiPxt is very close to the chordate group and appears to be the outgroup of mammalian MPO, EPO and TPO clades. The CiPxt molecular structure model resulted superimposable to the human myeloperoxidase. The CiPxt mRNA expression is upregulated by LPS …

Ulisse Aldrovandi: Vollendung des Aristoteles in plinianischer Manier

1994

The primary goal of Ulisse Aldrovandi was to surpass his immediate predecessor Conrad Gesner, despite the fact that he never mentioned it expressis verbis. In a Plinian manner he attempted to complete Aristotle's comprehensive description of the animals. Since he always made a great effort to evaluate all existing works, and to determine their degree of truth by conducting his own studies of nature, his descriptions turn out to be more comprehensive and critical than those of his predecessors. Furthermore he based his studies on a system and also incorporated anatomy again. With his studies of nature and anatomical dissections he has expanded the knowledge of scientific facts within the dom…

Baltu filoloģija, 26 (1)

2017

Mer Tyrosine Kinase (MERTK) modulates liver fibrosis progression and hepatocellular carcinoma development.

2022

BackgroundMerTK is a tyrosine kinase receptor that belongs to the TAM (Tyro3/Axl/Mer) receptor family. It is involved in different processes including cellular proliferation/survival, cellular adhesion/migration, and release of the inflammatory/anti-inflammatory cytokines. Although it is reported that MERTK polymorphisms affect the severity of viral and metabolic liver diseases, being able to influence fibrosis progression and hepatocellular carcinoma development, the mechanisms remain unknown. Methods: using a microarray approach, we evaluated the liver expression of genes involved in fibrogenesis and hepatocarcinogenesis in patient with chronic hepatitis C (CHC), stratified for MERTK geno…

El Arte Nuevo de Lope de Vega y su vigencia en nuestro teatro

2009

Reviving earthen architecture in Palestine: The added significances of the building sustainability and an opportunity for the future

2016

Several attempts have emerged recently in Palestine aiming to find an economical-environmental alternative building material beside the widely-used natural stone as a main building material, due to some factors related to the cost and the negative effects of stone mining areas on the local environment. Similar attempts had a certain response to the peculiar social needs and economic situation there. The efforts led to revive earthen architecture on organizational and individual levels, producing a certain number of earthen buildings in the last few years. In order to evaluate the appropriateness of earth as an alternative raw material in Palestine, the paper outlines the general advantages …

Random, asynchronous, and asymmetric transcriptional activity of enhancer-flanking major immediate-early genes ie1/3 and ie2 during murine cytomegalo…

2001

ABSTRACT The lungs are a major organ site of cytomegalovirus (CMV) pathogenesis, latency, and recurrence. Previous work on murine CMV latency has documented a high load and an even distribution of viral genomes in the lungs after the resolution of productive infection. Initiation of the productive cycle requires expression of the ie1/3 transcription unit, which is driven by the immediate-early (IE) promoter P 1/3 and generates IE1 and IE3 transcripts by differential splicing. Latency is molecularly defined by the absence of IE3 transcripts specifying the essential transactivator protein IE3. In contrast, IE1 transcripts were found to be generated focally and randomly, reflecting sporadic P …