Search results for "Loza"
showing 10 items of 64 documents
Mamá, quiero ser artista. La situación actual de la mujer en el panorama artístico
2011
La lucha reivindicativa de la mujer por hacerse un hueco en el panorama artístico se acentúa en los años setenta con grandes artistas que defienden sus derechos en Estados Unidos y Europa a través de nuevos medios como la fotografía o la performance. Éstas van abriendo hueco a sus generaciones posteriores. La herencia que ellas han dejado permite a la mujer trabajar sin plantearse cuestiones de género como sí se hacía en el pasado, aunque este hecho no significa que esté todo solucionado y que haya que bajar la guardia. La artista Natalia Lozano, artista emergente multidisciplinar, sirve como ejemplo para conocer qué situación se encuentra una mujer joven hoy en día y permite sacar una lect…
Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates.
2004
Abstract The pharmacokinetics of antipsychotic drugs has become an integral part in understanding their pharmacodynamic activity and clinical effects. In addition to metabolism aspects, carrier-mediated transport, particularly secretion by ABC transporters, has been discussed as potentially relevant for this group of therapeutics. In this study, the psychoactive compounds perphenazine, flupentixol, domperidone, desmethyl clozapine, haloperidol, fluphenazine, fluvoxamine, olanzapine, levome-promazine, perazine, desmethyl perazine, clozapine, quetiapine and amisulpride were characterized in terms of P-glycoprotein (P-gp) affinity and transport. Experimental methods involved a radioligand disp…
Antidepressants and Antipsychotic Drugs Colocalize with 5-HT(3) Receptors in Raft-Like Domains
2005
Despite different chemical structure and pharmacodynamic signaling pathways, a variety of antidepressants and antipsychotics inhibit ion fluxes through 5-HT3receptors in a noncompetitive manner with the exception of the known competitive antagonists mirtazapine and clozapine. To further investigate the mechanisms underlying the noncompetitive inhibition of the serotonin-evoked cation current, we quantified the concentrations of different types of antidepressants and antipsychotics in fractions of sucrose flotation gradients isolated from HEK293 (human embryonic kidney 293) cells stably transfected with the 5-HT3Areceptor and of N1E-115 neuroblastoma cells in relation to the localization of …
Lamentos al son del arpa. La imagen del rey David penitente en la pintura valenciana del Barroco
2015
Este artículo parte de dos lienzos de Pablo Pontons y Vicente Guilló para el estudio de la imagen del rey David, especialmente en su tipo iconográfico de David penitente. Formulado originalmente en las miniaturas medievales que se apoyaban en su papel de salmista y fundador de la música sacra, esta tipología tomó episodios de su vida que se convirtieron en modelos de penitencia. El trabajo estudia la tradición cultural convencionalizada de la gura de David, su patronazgo musical y la continuidad del tipo del rey penitente en el Barroco, tanto en grabados como en programas visuales como los de Pontons y Guilló para Morella y Alcalà de Xivert, respectivamente. Este uso didáctico per…
Reduction of clozapine-induced hypersalivation by pirenzepine is safe.
2004
Introduction Hypersalivation is known as a frequent, disturbing, and socially stigmatizing side effect of therapy with the atypical antipsychotic clozapine. It has been shown that the addition of the anticholinergic pirenzepine is able to reduce clozapine-induced hypersalivation, probably by blocking M4-receptors. Nevertheless, a pharmacokinetic interaction between both compounds cannot be excluded. Methods In this pilot study, 29 schizophrenic patients (ICD-10; 51.7 % female; age: 36.7 +/- 8.7 years [mean +/- SD]) were included. Serum concentrations of clozapine and its pharmacologically active metabolite N-desmethylclozapine were determined under steady-state conditions by automated HPLC …
Występowanie pałeczek Legionella sp. w instalacjach wodnych obiektów użyteczności publicznej w województwie opolskim w latach 2010-2011
2012
CEL PRACY. Ocena kolonizacji sieci wodnej szpitali i obiektów użyteczności publicznej bakteriami Legionella sp. w województwie opolskim, w latach 2010 – 2011. MATERIAŁ I METODY. Ocenę przeprowadzono na podstawie wykonanych w latach 2010 – 2011 badań ciepłej wody w kierunku Legionella oraz meldunków sprawozdawczych MZ-56 i MZ-57 dotyczących zachorowań na choroby zakaźne. WYNIKI. Przeprowadzone badania ciepłej wody wykazały, że znaczący odsetek budynków użyteczności publicznej w woj. opolskim posiada skolonizowaną instalację wodną bakteriami Legionella sp. W grupie zbadanych obiektów, największy procent obiektów z kolonizacją sieci wodnej bakteriami Legionella sp. stanowią szpitale (2010 - 63…
Phencyclidine inhibits the activity of thalamic reticular gamma-aminobutyric acidergic neurons in rat brain.
2014
Póster presentado en el IX Simposi de Neurobiologia Experimental, celebrado los días 22 y 23 de octubre de 2014 en Barcelona y organizado por la Societat Catalana de Biologia del Institut d'Estudis Catalans
Predicting how equipotent doses of chlorpromazine, haloperidol, sulpiride, raclopride and clozapine reduce locomotor activity in mice
2000
Distinguishing the specific effects of neuroleptics on one particular behaviour from its non-specific effects on motility is not easy. In this study, the effects of five neuroleptics on spontaneous motor activity were compared and the ED(50) values of these drugs to impair activity were calculated. Male and female mice were evaluated in an actimeter or in a shuttle-box used as an open field after the administration of chlorpromazine (0.4, 1.2, 3.6 mg/kg), haloperidol (0.1, 0.3, 0.9 mg/kg), raclopride (0.1, 0.3, 0.9 mg/kg), sulpiride (10, 30, 90 mg/kg) and clozapine (0.4, 1.2, 3.6 mg/kg), and two automatic and two observational activity measures were obtained. A very high correlation between…
Clozapine: Strong antiaggressive effects with minimal motor impairment
1992
Abstract Clinical studies have shown clozapine to be effective in the treatment of schizophrenia and associated with an extremely low incidence of extrapiramidal side effects. Diverse studies indicate that clozapine is an atypical neuroleptic with a preferential activity on the mesolimbic structures and a lower affinity for striatal D2 receptors than the classical antipsychotics. The purpose of this study was to assess the behavioral properties of clozapine, especially its effects on aggressive and motor behaviors. Individually housed male mice of the OF1 strain were exposed to anosmic “standard opponents” 30 minutes after the last drug administration. One category of animals received a sin…
Muscarinic Control of Histamine Release from Airways
2000
Isolated human bronchi and rat tracheae were incubated in organ baths to measure histamine release. The calcium ionophore A23187, 3 micromol/L in rat trachea and 10 micromol/L in human bronchi, stimulated histamine release by 145 +/- 50% (n = 6) and 270 +/- 48% (n = 7) above the prestimulation level, respectively. Acetylcholine (100 pmol/L; human bronchi) or oxotremorine (1, 100, 10,000 nmol/L; rat trachea) did not affect the spontaneous histamine release. In rat tracheae neither acetylcholine nor oxotremorine inhibited A23187-evoked histamine release, whereas 100 pmol/L acetylcholine significantly suppressed the evoked histamine release in human bronchi by 86%. For receptor characterizatio…