Search results for "Lp(a)"

Kiberdrošības politiku salīdzinājums Baltijas valstīs

2017

Darbā tiek aplūkota un salīdzināta Latvijas, Lietuvas un Igaunijas situācija kiberdrošības jomā, lai noskaidrotu, vai un cik lielā mērā starp trim Baltijas valstīm pastāv atšķirības kiberdrošības politikas instrumentu attīstībā. Drošībošanas koncepta ietvaros tiek pārbaudīts, vai 2007. gada kiberuzbrukumus Igaunijai var uzskatīt par sekmīgi veiktu drošībošanas procesu. Izanalizējot pieejamo informāciju, tiek secināts, ka Igaunijas gadījums nav attiecināms uz drošībošanas teorijas ietvaru. Tomēr kiberuzbrukumi Igaunijā ir veicinājuši kiberdrošības koncepta attīstību Igaunijā. Darba nobeigumā tiek secināts, ka nav pamata apgalvot, ka Igaunijā šobrīd ir sasniegts ievērojami lielāks progress ki…

Biomonitoring of bisphenols A, F, S and parabens in urine of breastfeeding mothers: Exposure and risk assessment

2019

In the present study we used human biomonitoring to assess the internal exposure and the risk to four parabens and three bisphenols in 103 Spanish breastfeeding mothers participating in the BETTERMIILK project. Urinary methylparaben (MP), ethylparaben (EP), propylparaben (PP) and butylparaben (BP) presented detection frequencies ranging from 12% (BP) to 92% (MP), while bisphenol A (BPA), bisphenol F (BPF) and bisphenol S (BPS) were detected in 76% (BPA) and 20% (BPF, BPS) of the mothers. Average paraben concentrations (geometric mean) ranged from 0.021 ng mL(-1) (BP) to 17.7 ng mL(-1) (MP), whereas bisphenols had geometric means concentrations from 0.042 ng mL(-1) (BPF) to 0.927 ng mL(-1) (…

Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization.

2012

Our aim was to elucidate the physiological role of calpains (CAPN) in mammary gland involution. Both CAPN-1 and -2 were induced after weaning and its activity increased in isolated mitochondria and lysosomes. CAPN activation within the mitochondria could trigger the release of cytochrome c and other pro-apoptotic factors, whereas in lysosomes it might be essential for tissue remodeling by releasing cathepsins into the cytosol. Immunohistochemical analysis localized CAPNs mainly at the luminal side of alveoli. During weaning, CAPNs translocate to the lysosomes processing membrane proteins. To identify these substrates, lysosomal fractions were treated with recombinant CAPN and cleaved produc…

Targeting the mitochondrial pathway to induce apoptosis/necrosis through ROS by a newly developed Schiff’s base to overcome MDR in cancer

2011

Abstract Multidrug resistance (MDR) in cancer, a major obstacle to successful application of cancer chemotherapy, is often characterized by over-expression of multidrug resistance-related proteins such as MRP1, P-gp or elevated glutathione (GSH) level. Efflux of drugs by functional P-gp, MRP1 and elevated GSH level can confer resistance to apoptosis induced by a range of different stimuli. Therefore, it is necessary to develop new cell death inducers with relatively lower toxicity toward non-malignant cells that can overcome MDR by induction of apoptotic or non-apoptotic cell death pathways. Herein we report the synthesis and spectroscopic characterization of a GSH depleting, redox active S…

µ-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptos…

2011

Anti-apoptotic Bfl-1 and pro-apoptotic Bax, two members of the Bcl-2 family sharing a similar structural fold, are classically viewed as antagonist regulators of apoptosis. However, both proteins were reported to be death inducers following cleavage by the cysteine protease µ-calpain. Here we demonstrate that calpain-mediated cleavage of full-length Bfl-1 induces the release of C-terminal membrane active α-helices that are responsible for its conversion into a pro-apoptotic factor. A careful comparison of the different membrane-active regions present in the Bfl-1 truncated fragments with homologous domains of Bax show that helix α5, but not α6, of Bfl-1 induces cell death and cytochrome c r…

Calpain 1 and 2 Are Required for RNA Replication of Echovirus 1▿

2007

ABSTRACT Calpains are calcium-dependent cysteine proteases that degrade cytoskeletal and cytoplasmic proteins. We have studied the role of calpains in the life cycle of human echovirus 1 (EV1). The calpain inhibitors, including calpeptin, calpain inhibitor 1, and calpain inhibitor 2 as well as calpain 1 and calpain 2 short interfering RNAs, completely blocked EV1 infection in the host cells. The effect of the inhibitors was not specific for EV1, because they also inhibited infection by other picornaviruses, namely, human parechovirus 1 and coxsackievirus B3. The importance of the calpains in EV1 infection also was supported by the fact that EV1 increased calpain activity 3 h postinfection. …

Stāstu krājuma „Purpura karaļa galmā” telpas poētika

2015

Bakalaura darbā veikts pētījums par spekulatīvās literatūras – fantāzijas, zinātniskās fantastikas un šausmu lietaratūras – telpas poētiku pirmajā latviešu autoru fantāzijas un zinātniskās fantastikas stāstu krājumā „Purpura karaļa galmā”, kas iznācis 2013.gadā. Latviešu literatūras attīstību ļoti iespaidojuši vēsturiski notikumi, kas ietekmējuši arī pieminēto žanru attīstību, kas ir viens no iemesliem, kādēļ tikai pēdējās desmitgadēs latviešu autori ir pievērsušies rakstīšanai fantāzijas un zinātniskās fantastikas žanrā. Telpas aspekts spekulatīvajā literatūrā ir bijs viens no galvenajiem žanra elementiem, tādēļ darba mērķis ir noskaidrot, ar kādiem paņēmieniem telpu stāstos attēlo latvieš…

Reliģiski-filozofiski raksti, 20

2016

Katrā no rakstiem, kas publicēti šajos "Reliģiski-filozofiskos rakstos", šķiet, iespējams saskatīsim gan pagātnes sprostā patvērušos brīvību ar tās apreibinošajās ilūzijām par neatkarību ārpus sprosta, gan nojaust neatrisināmo un reizēm iznīcinošo dilemmu starp gara un reālo pasauli, starp spēli un brīdi, kad spēle beidzas. Piemēram, par pagātnē iesprostotas virtuālās pasaules konstruēšanu, kuras brīvībā izlaušanās mērāma iznīcinātu dzīvību tūkstošos, mums stāsta Māris Kūlis savā rakstā “Islāma valsts propaganda digitālajā laikmetā”. Uzsverot, ka Islāma valsts īstenotais militārais un ārkārtīgi agresīvais džihāds ar vēl nepieredzētām sekmēm ir izveidojis sinkrētisku reliģiskās degsmes un mū…

Reazioni pulpari alla malattia parodontale: studio istologico e istobatteriologico

2003

DANNO, RISARCIMENTO E RICONOSCIMENTO DELL’“ALTRO” NELLA GESTIONE DEI CONFLITTI IN OMERO

2019

Atto ingiusto, reato? Nel mondo omerico abbiamo a che fare: 1. con atasthalìai (in Omero solo al plurale), cioè con “eccessi-volontari-e-consapevoli fondati-sulla-fiducia nella-propria-forza/capacità/potere”, di cui si è responsabili (mentre non si è responsabili o si è innocenti se si obbedisce a cause materiali/umane di forza maggiore), o 2. con àte, l’offuscamento mentale che rovina se stessi e a volte gli altri e che si è avuto per propria imprudenza, mancanza di calcolo o perché gli dei puniscono di una precedente offesa fatta loro. In quest’ultimo caso, si può rimediare oppure bisogna aspettare i tempi della divinità. Nel caso di offese ad altri uomini, bisogna risarcire materialmente…