Search results for "Lua"

Acute and delayed toxicity of gemcitabine administered during isolated lung perfusion: a preclinical dose-escalation study in pigs.

2014

BACKGROUND: Colorectal cancer is the third most commonly diagnosed cancer worldwide, with up to 25% of patients presenting with metastases at the time of diagnosis. Despite pulmonary metastasectomy many patients go on to develop pulmonary recurrence, which might be linked to the presence of lung micrometastases. In this setting, the adjuvant administration of high-dose chemotherapy by isolated lung perfusion (ILP) has shown encouraging results. However, the tolerance to and efficacy of modern gemcitabine (GEM)-based chemotherapy regimens during adjuvant ILP remain unknown. We conducted a dose-escalating preclinical study to evaluate the immediate and delayed toxicity of GEM in a pig model t…

Long-term volume-targeted pressure-controlled ventilation: sense or nonsense?

2017

The technology underlying the development of novel ventilatory modes for long-term noninvasive ventilation of patients with chronic hypercapnia is continuously evolving. Volume-targeted pressure-controlled ventilation is a hybrid ventilation mode designed to combine the advantages of conventional ventilation modes, while avoiding their drawbacks. However, manufacturers have created different names and have patented algorithms and set-up variables, which can result in confusion for physicians and respiratory therapists. In addition, clear evidence for the superiority of this novel mode has not yet been established. These factors have most likely hindered more widespread use of this mode in c…

Laser Welding - Suitable for Vascular Anastomosis?

1994

Carotid arteries of 21 piglets were transsected and reanastomosed either by laser welding (Neodym:YAG laser) or by conventional suture anastomosis. Histological specimens of the anastomoses obtained 2 to 32 days after the operation showed less foreign body reaction and intimal hyperplasia after laser welding than after suturing. There was, however, no significant difference when comparing occurrence of thrombosis, patency rate, or growth of the anastomosis in growing animals. Neither our study nor a review of the literature of laser-assisted vascular anastomosis in microvessels and large arteries up to 5 mm diameter could establish a definite clinical application for laser welding in vascul…

Escala de desarrollo armónico (EDA): Una propuesta para la evaluación clínica del desarrollo infantil desde la Teoría de Sistemas

2020

Los profesionales de las ciencias de la salud y de la educación necesitan herramientas adecuadas para llevar a cabo la prevención de los trastornos del desarrollo infantil. La Escala de Desarrollo Armónico –EDA–, se presenta como una propuesta que permite la coordinación interdisciplinaria y la colaboración de los educadores. La escala se ha construido para observar el ascenso del paisaje epigenético individual desde el paradigma de los sistemas dinámicos. Para lograrlo, se han estudiado parámetros que pueden explicar la evolución del sistema –índice de armonía y cociente de desarrollo estable–, un mecanismo del cambio –tirón cognitivo– y fuerzas moldeadoras –velocidad y cristalización–, si…

La rete intercomunale del corleonese per un’azione di prevenzione e lotta al Punteruolo rosso delle palme.

2009

On the blockwise modular isomorphism problem

2017

As a generalization of the modular isomorphism problem we study the behavior of defect groups under Morita equivalence of blocks of finite groups over algebraically closed fields of positive characteristic. We prove that the Morita equivalence class of a block B of defect at most 3 determines the defect groups of B up to isomorphism. In characteristic 0 we prove similar results for metacyclic defect groups and 2-blocks of defect 4. In the second part of the paper we investigate the situation for p-solvable groups G. Among other results we show that the group algebra of G itself determines if G has abelian Sylow p-subgroups.

Synthesis and preliminary biological evaluation of a new pyridocarbazole derivative covalently linked to a thymidine nucleoside as a potential target…

2003

The therapy of human cancer is one of the more pursued goals by medicinal chemistry research. Most of the compounds clinically used as a treatment owe their efficacy to their cytotoxic interaction (direct or indirect) with nuclear DNA. This interaction results in the inhibition of DNA synthesis and the degradation of nucleic strands. Ellipticine is a naturally occurring 6H-pyrido[4,3-b]carbazole alkaloid endowed with antitumor activity, and several ellipticine derivatives have been used in clinical trials. We previously reported some 1,4-dimethyl-9H-carbazole derivatives structurally related to ellipticine. The purpose of our research was to transform the pyridocarbazole in a prodrug so tha…

Peut-on parler de recherche en pédagogie universitaire, aujourd'hui, en France ?

2008

08102; Définir la pédagogie universitaire et savoir ce qu'elle recouvre en France en termes de recherche constitue un enjeu. En effet, le manque de visibilité et de lisibilité de ce champ en limitent probablement la portée à l'heure où la notion de qualité semble se faire plus pressante dans le contexte universitaire français. En partant d'une définition opérationnelle de ce que l'on peut entendre par pédagogie universitaire en France et en s'appuyant sur une recherche documentaire effectuée à partir de la base de données Francis ainsi que de la consultation de programmes complets de différents colloques, cet article vise à mettre en perspective et à illustrer les principaux axes de recherc…

Le caractère formatif d'un dispositif d'évaluation des enseignements par les étudiants (EEE)

2014

International audience; Cet article examine un dispositif d'évaluation des enseignements par les étudiants (EEE) en analysant les choix des équipes pédagogiques concernant les questionnaires qu'elles conçoivent. Cette étude est menée afin d'étudier la place possible de l'EEE dans le cadre de l'évaluation-conseil. En effet, pour que l'EEE soit utile aux enseignants, il convient que les questions posées aux étudiants permettent aux enseignants comme aux professionnels de l'accompagnement de s'inscrire dans une logique d'évaluation-conseil. Les résultats montrent leur intérêt dans ce cadre en fournissant aux enseignants des données qui leur permettent de conforter ou de modifier leurs enseigne…

Impacts des évaluations des enseignements sur le développement professionnel pédagogique des enseignants du supérieur

2018

International audience