Search results for "Lua"

Solution versus Fluorous versus Solid-Phase Synthesis of 2,5-Disubstituted 1,3-Azoles. Preliminary Antibacterial Activity Studies

2009

A small library of compounds with an oxa(thia)zole scaffold and structural diversity in both positions 2 and 5 has been synthesized. Double acylation of a protected glycine affords intermediate α-amido-β-ketoesters, which in turn can be dehydrated to afford 1,3-oxazoles or reacted with Lawesson’s reagent to furnish 1,3-thiazoles. This procedure was designed with its adaptation to fluorous techniques in mind. Thus, when a protected glycine with a fluorous tag in the ester moiety is used as a starting material, the synthesis can be easily completed without column chromatography purification of intermediate compounds with good to excellent yields, thus affording a suitable entry to the prepara…

DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL HETEROCYCLIC DERIVATIVES AS MODULATORS OF B-DNA AND G-QUADRUPLEXES DNA FUNCTIONS

Operator splitting methods for American option pricing

2004

Abstract We propose operator splitting methods for solving the linear complementarity problems arising from the pricing of American options. The space discretization of the underlying Black-Scholes Scholes equation is done using a central finite-difference scheme. The time discretization as well as the operator splittings are based on the Crank-Nicolson method and the two-step backward differentiation formula. Numerical experiments show that the operator splitting methodology is much more efficient than the projected SOR, while the accuracy of both methods are similar.

Physical exercise and prevention of falls. Effects of a Pilates training method compared with a general physical activity program

2021

Introduction Falls are the leading cause of injury-related mortality and morbidity in the elderly. Physical activity plays a key role in the prevention of falls and stimulates postural control. The aim of this study was to compare a general physical activity program for the elderly with a Pilates program to evaluate the effects on balance and on reducing the risk of falling. Materials and methods Forty-six subjects were enrolled in this study, but only 41 were included in the study. The subjects were divided into 2 groups: Pilates group (P-G) and a group following a nonspecific program of physical activity (Pa-G). Each subject underwent the hand grip test, Berg balance scale test, and postu…

Battery characterization via eddy-current imaging with nitrogen-vacancy centers in diamond

2021

Sensitive and accurate diagnostic technologies with magnetic sensors are of great importance for identifying and localizing defects of rechargeable solid batteries in a noninvasive detection. We demonstrate a microwave-free AC magnetometry method with negatively charged NV centers in diamond based on a cross-relaxation feature between NV centers and individual substitutional nitrogen (P1) centers occurring at 51.2 mT. We apply the technique to non-destructive solid-state battery imaging. By detecting the eddy-current-induced magnetic field of the battery, we distinguish a defect on the external electrode and identify structural anomalies within the battery body. The achieved spatial resolut…

Efficient contactless power transfer system for EVs

2016

Based on the inductive power transfer (IPT), the contactless approach allows safe and comfortable operations of battery charging for Electric Vehicles (EVs). In this paper, a contactless system particularly suitable for E-bike battery charging is proposed. A practical realization of the system has been carried out, aiming at the system evaluation in terms of working and efficiency. Through a phase shift modulation, a power regulation has been implemented. The target power level is 100 W.

Integrating the human factor in FMECA-based risk evaluation through Bayesian networks

2020

The contribution of the present paper aims to develop the traditional Failure Modes, Effects and Criticality Analysis (FMECA) for quantitative risk analysis from a Bayesian Network (BN)-based perspective. The main purpose of research consists in providing a framework for analysing causal relationships for risk evaluation and deriving probabilistic inference among significant risk factors. These parameters will be represented by linguistic variables and will include the human factor as a key element of analysis. Traditional approaches for risk evaluation and management performed by FMECA [1] represent helpful tools to globally enhance systems and processes conditions [2]. However, such appro…

Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis

2018

Abstract: Chemotherapy is currently the only effective approach to treat all forms of leishmaniasis. However, its effectiveness is severely limited due to high toxicity, long treatment length, drug resistance, or inadequate mode of administration. As a consequence, there is a need to identify new molecular scaffolds and targets as potential therapeutics for the treatment of this disease. We report a small series of 1,2‐substituted‐1H‐benzo[d]imidazole derivatives (9ad) showing affinity in the submicromolar range (Ki = 0.150.69 μM) toward Leishmania mexicanaCPB2.8ΔCTE, one of the more promising targets for antileishmanial drug design. The compounds confirmed activity in vitro against intrace…

Bibliometric analysis of the Annual Review of Legal Psychology journal between 1991-2019

2021

[EN]: The present study carries out a bibliometric analysis of Annual Review of Legal Psychology from 1991 to 2019. Data were collected from a database that allows for the analysis of authors, institutions, countries, gender, topics, and impact. The results enable us to observe gender discrepancies among authors, with a a higher frequency of women (50.2%), and the number of signatures (53.7% men). Over the years there is an increase in the number of authors and signatures, of co-authorship, a higher presence of international signatures, representing 23.5% between 2011 and 2019. Three collaboration groups were identified, two from Spain and one from Colombia. Categories of Legal and Forensic…

Revista electrónica de investigación y evaluación educativa

2020

Objetivos: Análisis bibliométrico de los trabajos publicados por RELIEVE en los últimos 15 años; que se corresponden con los procesados por Emerging Sources Citation Index (ESCI), una nueva base de datos de Web of Science (WOS) que pretende corregir la deficiente cobertura de las revistas nacionales de algunos países. Método: Fuente de datos: 195 artículos de RELIEVE recogidos en ESCI. Análisis: Se analizaron las 7.408 referencias emitidas por los 195 trabajos. Igualmente se analizaron las 599 citas recibidas por la revista. Temáticas cubiertas: se volcaron las Author-Keywords de los 195 trabajos en la herramienta de software VOSviewer. Resultados: las citas emitidas arrojan un promedio por…