Search results for "Lung"
showing 10 items of 2389 documents
Parathyroid hormone-related protein (PTHrP)-dependent modulation of gene expression signatures in cancer cells
2022
PTHrP is encoded by PTHLH gene which can generate by alternative promoter usage and splicing mechanisms at least three mature peptides of 139, 141 and 173 amino acids with distinct carboxy terminus. PTHrP may undergo proteolytic processing into smaller bioactive forms, comprising an amino terminus peptide, which is the mediator of the "classical" PTH-like effect, as well as midregion and carboxy terminus peptides that act as multifaceted critical regulator of proliferation, differentiation and apoptosis via the reprogramming of gene expression in normal and neoplastic cells. Moreover, a nuclear/nucleolar localization signal sequence is present in the [87-107] domain allowing PTHrP nuclear i…
Study of Beauty Hadron Decays into Pairs of Charm Hadrons
2014
First observations of the decays Λ[0 over b] → Λ[+ over c]D[− over (s)] are reported using data corresponding to an integrated luminosity of 3 fb[superscript −1] collected at 7 and 8 TeV center-of-mass energies in proton-proton collisions with the LHCb detector. In addition, the most precise measurement of the branching fraction B(B[0 over s] → D[superscript +]D[− over s]) is made and a search is performed for the decays B[0 over (s)] → Λ[+ over c]Λ[− over c]. The results obtained are B(Λ[0 over b] → Λ[+ over c]D[superscript −])/B(Λ[0 over b] → Λ[+ over c]D[− over s]) = 0.042 ± 0.003(stat) ± 0.003(syst), ⎡⎣B(Λ[0 over b] → Λ[+ over c]D[− over s]) over B([¯ over B[superscript 0] → D[superscr…
Neutrinoless Double-Electron Capture
2020
Double-beta processes play a key role in the exploration of neutrino and weak interaction properties, and in the searches for effects beyond the Standard Model. During the last half century many attempts were undertaken to search for double-beta decay with emission of two electrons, especially for its neutrinoless mode ($0\nu2\beta^-$), the latter being still not observed. Double-electron capture (2EC) was not in focus so far because of its in general lower transition probability. However, the rate of neutrinoless double-electron capture ($0\nu2$EC) can experience a resonance enhancement by many orders of magnitude in case the initial and final states are energetically degenerate. In the re…
Beam-Helicity Asymmetries in Double-Charged-Pion Photoproduction on the Proton
2005
Beam-helicity asymmetries for the two-pion-photoproduction reaction gamma + p --> p pi+ pi- have been studied for the first time in the resonance region for center-of-mass energies between 1.35 GeV and 2.30 GeV. The experiment was performed at Jefferson Lab with the CEBAF Large Acceptance Spectrometer using circularly polarized tagged photons incident on an unpolarized hydrogen target. Beam-helicity-dependent angular distributions of the final-state particles were measured. The large cross-section asymmetries exhibit strong sensitivity to the kinematics and dynamics of the reaction. The data are compared with the results of various phenomenological model calculations, and show that these…
First observation of the doubly charmed baryon decay Ξcc++→Ξc+π+
2018
The doubly charmed baryon decay Ξcc++→Ξc+π+ is observed for the first time, with a statistical significance of 5.9σ, confirming a recent observation of the baryon in the Λc+K−π+π+ final state. The data sample used corresponds to an integrated luminosity of 1.7 fb−1, collected by the LHCb experiment in pp collisions at a center-of-mass energy of 13 TeV. The Ξcc++ mass is measured to be 3620.6±1.5(stat)±0.4(syst)±0.3(Ξc+) MeV/c2 and is consistent with the previous result. The ratio of branching fractions between the decay modes is measured to be [B(Ξcc++→Ξc+π+)×B(Ξc+→pK−π+)]/[B(Ξcc++→Λc+K−π+π+)×B(Λc+→pK−π+)]=0.035±0.009(stat)±0.003(syst).
Measurement of the c0 Baryon Lifetime
2018
We report a measurement of the lifetime of the $��_c^0$ baryon using proton-proton collision data at center-of-mass energies of 7 and 8~TeV, corresponding to an integrated luminosity of 3.0 fb$^{-1}$ collected by the LHCb experiment. The sample consists of about 1000 $��_b^-\to��_c^0��^-\bar��_�� X$ signal decays, where the $��_c^0$ baryon is detected in the $pK^-K^-��^+$ final state and $X$ represents possible additional undetected particles in the decay. The $��_c^0$ lifetime is measured to be $��_{��_c^0} = 268\pm24\pm10\pm2$ fs, where the uncertainties are statistical, systematic, and from the uncertainty in the $D^+$ lifetime, respectively. This value is nearly four times larger than, …
Study of W Boson Production in Association with Beauty and Charm
2015
The associated production of a W boson with a jet originating from either a light parton or heavy-flavor quark is studied in the forward region using proton-proton collisions. The analysis uses data corresponding to integrated luminosities of 1.0 and 2.0 fb[superscript -1] collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV, respectively. The W bosons are reconstructed using the W → μν decay and muons with a transverse momentum, p[subscript T], larger than 20 GeV in the pseudorapidity range 2.0 20 GeV and 2.2 20 GeV. The fraction of W + jet events that originate from beauty and charm quarks is measured, along with the charge asymmetries of the W + b and W + c produ…
Lung myofibroblasts are characterized by down-regulated cyclooxygenase-2 and its main metabolite, prostaglandin E2.
2013
Background: Prostaglandin E2 (PGE(2)), the main metabolite of cyclooxygenase (COX), is a well-known anti-fibrotic agent. Moreover, myofibroblasts expressing alpha-smooth muscle actin (alpha-SMA), fibroblast expansion and epithelial-mesenchymal transition (EMT) are critical to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Our aim was to investigate the expression of COX-2 and PGE(2) in human lung myofibroblasts and establish whether fibroblast-myofibroblast transition (FMT) and EMT are associated with COX-2 and PGE(2) down-regulation. Methods: Fibroblasts obtained from IPF patients (n = 6) and patients undergoing spontaneous pneumothorax (control, n = 6) and alveolar epithelial ce…
IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease
2011
Interleukin (IL)-22 is an effector cytokine, which acts primarily on epithelial cells in the skin, gut, liver and lung. Both pro- and anti-inflammatory properties have been reported for IL-22 depending on the tissue and disease model. In a murine model of allergic airway inflammation, we found that IL-22 is predominantly produced by innate lymphoid cells in the inflamed lungs, rather than TH cells. To determine the impact of IL-22 on airway inflammation, we used allergen-sensitized IL-22-deficient mice and found that they suffer from significantly higher airway hyperreactivity upon airway challenge. IL-22-deficiency led to increased eosinophil infiltration lymphocyte invasion and production…
Predicting Lung Deposition of Extrafine Inhaled Corticosteroid-Containing Fixed Combinations in Patients with Chronic Obstructive Pulmonary Disease U…
2021
Background: Functional respiratory imaging (FRI) is a computational fluid dynamics-based technique using three-dimensional models of human lungs and formulation profiles to simulate aerosol deposition. Methods: FRI was used to evaluate lung deposition of extrafine beclomethasone dipropionate (BDP)/formoterol fumarate (FF)/glycopyrronium bromide (GB) and extrafine BDP/FF delivered through pressurized metered dose inhalers and to compare results with reference gamma scintigraphy data. FRI combined high-resolution computed tomography scans of 20 patients with moderate-to-severe chronic obstructive pulmonary disease (mean forced expiratory volume in 1 second 42% predicted) with in silico comput…