Search results for "Lung"

Hitler A Bayreuth. Storia di un'amicizia (1923-1940)

2013

Il saggio si sofferma sulle vite parallele di Winifred Majorie Williams (moglie di Sigfried Wagner e dopo la sua morte "Signora di Bayreuth") e Adolf Hitler, grande ammiratore dell'opera wagneriana e "amico" di famiglia della famiglia Wagner a partire dalla fine degli anni Venti. Il testo ripercorre le tappe del rapporto personale fra Winifred Wagner e Adolf Hitler, rievocando al tempo stesso alcuni episodi della biografia hitleriana legati al Festival di Bayreuth.

"Kai sitä nyt jotain sivistyksen puolikasta tässäkin lafkassa voisi esittää..." : Spracheinstellungen des Universitätspersonals in Finnland unter bes…

2017

Yliopistojen strategisen kansainvälistymisen myötä englannin asema lingua francana kaikilla akateemisen työn osa-alueilla (tutkimus, opettaminen, palvelut ja hallinto) ja tieteenaloilla on voimistunut. Toisaalta myös monikielisyys on perinteisesti ollut hallitseva ideologia akateemisissa piireissä, sillä useiden kielten osaamista pidetään mm. yhtenä sivistyksen mittarina. Monikielisyyttä ja kielellistä monimuotoisuutta pyritään tukemaan myös esimerkiksi EU:n virallisissa dokumenteissa, ja vieraiden kielten taito on korostuneessa asemassa myös työelämän kielitaitotarpeita arvioivissa tutkimuksissa. Tämän tutkimuksen tarkoituksena on selvittää, onko Suomen yliopistojen henkilökunnan mielestä …

Neoclassical Convergence Versus Technological Catch-Up : A Contribution for Reaching a Consensus.

2004

http://www.businessperspectives.org/files/ppm/PPM_EN_2004_03pp15_42.pdf; International audience; New macro empirical evidence is provided to assess the relative importance of object andidea gaps in explaining the world income distribution dynamics over a benchmark period of 1960-1985. Results are then extended through 1995. Formal statistical hypothesis tests allow us to discriminatebetween two competing growth models: (i) the standard neoclassical growth model similarto that employed by Mankiw, Romer, and Weil (1992), and (ii) an endogenous growth modelclosely related to the Nelson and Phelps' approach (1966) that emphasizes the importance of technologytransfer in addition to factor accumu…

The Bible in the films of Pavel Lungin and Andrei Zvyagintsev

2018

In the Soviet Union, even after perestroika, explicitly biblical films have practically not been produced; nevertheless the Bible, despite acute censorship, has been present in a symbolic way in films directed by Andrei Tarkovsky and Larissa Shepitko. A certain revival of biblical themes is evident in recent works of Russian directors Pavel Lungin (Island, 2006; The Conductor, 2012), and Andrei Zvyagintsev (The Return, 2003; Leviathan, 2014). The paper analyzes the meaning of the Bible in these films: biblical texts are quoted in dialogues, and evoked in the titles and the protagonists’ names; biblical motifs are present in images, in contemporary events, and in the narrative structures. Th…

Rigaer Jubiläums-Ausstellung für Industrie und Gewerbe, 1901

1901

Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma

2019

AIMS: Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases. METHODS: MASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a multi-disciplinary group centred around the patients. STAKEHOLDERS: Incl…

Investigation of the Electromagnetic Radiation Emitted by Sub-GeV Electrons in a Bent Crystal.

2015

The radiation emitted by 855 MeV electrons via planar channeling and volume reflection in a $30.5\text{\ensuremath{-}}\ensuremath{\mu}\mathrm{m}$-thick bent Si crystal has been investigated at the MAMI (Mainzer Mikrotron) accelerator. The spectral intensity was much more intense than for an equivalent amorphous material, and peaked in the MeV range in the case of channeling radiation. Differently from a straight crystal, also for an incidence angle larger than the Lindhard angle, the spectral intensity remains nearly as high as for channeling. This is due to volume reflection, for which the intensity remains high at a large incidence angle over the whole angular acceptance, which is equal t…

Osteopontin shapes immunosuppression in the metastatic niche.

2014

Abstract The matricellular protein osteopontin (OPN, Spp-1) is widely associated with cancer aggressiveness when produced by tumor cells, but its impact is uncertain when produced by leukocytes in the context of the tumor stroma. In a broad study using Spp1−/− mice along with gene silencing in tumor cells, we obtained evidence of distinct and common activities of OPN when produced by tumor or host cells in a spontaneously metastatic model of breast cancer. Different cellular localization of OPN is associated with its distinct activities, being mainly secreted in tumor cells while intracellular in myeloid cells. OPN produced by tumor cells supported their survival in the blood stream, wherea…

Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma.

2010

Signal transducer and activator of transcription (STAT)-3 inhibitors play an important role in regulating immune responses. Galiellalactone (GL) is a fungal secondary metabolite known to interfere with the binding of phosphorylated signal transducer and activator of transcription (pSTAT)-3 as well of pSTAT-6 dimers to their target DNA in vitro. Intra nasal delivery of 50 μg GL into the lung of naive Balb/c mice induced FoxP3 expression locally and IL-10 production and IL-12p40 in RNA expression in the airways in vivo. In a murine model of allergic asthma, GL significantly suppressed the cardinal features of asthma, such as airway hyperresponsiveness, eosinophilia and mucus production, after…

PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion.

2015

Abstract Correct apicobasal polarization and intercellular adhesions are essential for the appropriate development of normal epithelia. Here, we investigated the contribution of the cell polarity regulator PARD3 to the development of lung squamous cell carcinomas (LSCC). Tumor-specific PARD3 alterations were found in 8% of LSCCs examined, placing PARD3 among the most common tumor suppressor genes in this malignancy. Most PAR3-mutant proteins exhibited a relative reduction in the ability to mediate formation of tight junctions and actin-based protrusions, bind atypical protein kinase C, activate RAC1, and activate STAT3 at cell confluence. Thus, PARD3 alterations prevented the formation of c…