Search results for "Lung"
showing 10 items of 2389 documents
Mundus et: Idea. Homo. Communitas. Sciens : zinātnisko rakstu krājums
2021
LU Studentu zinātnisko rakstu krājums “Mundus et” ir Latvijas Universitātes Studentu padomes organizētās LU Studentu zinātniskās konferences “Mundus et” jauno pētnieku darbu apkopojums.
Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-…
2021
Obesity has complex links to respiratory health. Mendelian randomization (MR) enables assessment of causality of body mass index (BMI) effects on airflow obstruction and mid-expiratory flow. In the adult SAPALDIA cohort, recruiting 9,651 population-representative samples aged 18–60 years at baseline (female 51%), BMI and the ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) as well as forced mid-expiratory flow (FEF25–75%) were measured three times over 20 follow-up years. The causal effects of BMI in childhood and adulthood on FEV1/FVC and FEF25–75% were assessed in predictive (BMI averaged over 1st and 2nd, lung function (LF) averaged over 2nd and 3rd fol…
The Flow-Volume-Measurement in Computer-Supported Lung Function Analysis
1982
For some years computers have been applied more and more in pulmonary function laboratories. On the one hand the medico-technical industry could connect older diagnostic systems with new calculators, on the other hand completely computerised lung function desks have been developed.
Vitamin A deficiency alters rat lung alveolar basement membrane: reversibility by retinoic acid.
2010
Vitamin A is essential for lung development and pulmonary cell differentiation and its deficiency results in alterations of lung structure and function. Basement membranes (BMs) are also involved in those processes, and retinoic acid, the main biologically active form of vitamin A, influences the expression of extracellular matrix macromolecules. Therefore, we have analyzed the ultrastructure and collagen content of lung alveolar BM in growing rats deficient in vitamin A and the recovering effect of all-trans retinoic acid. Male weanling pups were fed a retinol-adequate or -deficient diet until they were 60 days old. A group of vitamin A-deficient pups were recovered by daily intraperitonea…
Vitamin A in parenteral nutrition: uptake and distribution of retinyl esters after intravenous application.
1989
Short-term parenteral application of vitamin A was examined in rats. Retinyl margarinate, which is chemically similar to physiological retinyl esters, was used in vitamin A-depleted rats to study uptake, distribution, and storage of retinyl esters in tissues. Vitamin A-depleted and Vitamin A-sufficient rats were infused with a micellar suspension of retinyl margarinate for 7 h and then killed at different times. Retinyl margarinate was directly taken up by all tissues examined. It appears that infusion of retinyl esters in micellar form provides a direct way to supply vitamin A to peripheral, vitamin A-dependent tissues. Therefore, a short-term infusion of retinyl esters with an emulsifier …
Vitamin A Deficiency and Alterations in the Extracellular Matrix
2014
Vitamin A or retinol which is the natural precursor of several biologically active metabolites can be considered the most multifunctional vitamin in mammals. Its deficiency is currently, along with protein malnutrition, the most serious and common nutritional disorder worldwide. It is necessary for normal embryonic development and postnatal tissue homeostasis, and exerts important effects on cell proliferation, differentiation and apoptosis. These actions are produced mainly by regulating the expression of a variety of proteins through transcriptional and non-transcriptional mechanisms. Extracellular matrix proteins are among those whose synthesis is known to be modulated by vitamin A. Reti…
Beyond GDP: an analysis of the socio-economic diversity of European regions
2019
International audience; This paper aims to analyze the socioeconomic diversity of the European Union (EU-28) regions from a dynamic perspective. For that purpose, we combine a series of exploratory space-time analysis approaches to multiple Factor Analysis (MFA) applied to a large range of indicators collected at the NUTS-2 level for the period 2000–2015 for the EU-28. First, we find that the first factor of MFA, interpreted as economic development (ECO-DEV), is spatially clustered and that a moderate convergence process is at work between European regions from 2000 to 2015. Second, when comparing these results with those obtained for Gross Domestic Product (GDP) per capita, we show that th…
"Tutto quel che è, finisce". Guida a "L'Anello del Nibelungo" di Richard Wagner
2017
Il volume costituisce una guida completa e aggiornata al sistema drammaturgico-musicale wagneriano, alla sua ricchezza concettuale e ai presupposti estetici, filosofici e politici che ne furono alla base. È costituito da un’ampia introduzione dedicata alle suddette premesse (con numerose citazioni dagli scritti di Wagner), seguita da un ‘racconto’ dettagliato delle vicende – innanzi tutto "musicali" – dei quattro drammi, in altrettanti capitoli. La trattazione si avvale degli apporti ermeneutici più significativi, da quelli storici di Nietzsche, George Bernard Shaw, Thomas Mann, T. W. Adorno a quelli più recenti. Corredata degli esempi musicali relativi a tutti i Leitmotive e di tavole che …
Cancer risk among residents of Rhineland-Palatinate winegrowing communities: a cancer-registry based ecological study
2008
Abstract Aim To investigate the cancer risk among residents of Rhineland-Palatinate winegrowing communities in an ecological study. Methods On the basis of the Rhineland-Palatinate cancer-registry, we calculated age-adjusted incidence rate ratios for communities with a medium area under wine cultivation (>5 to 20 percent) and a large area under wine cultivation (>20 percent) in comparison with communities with a small area under wine cultivation (>0 to 5 percent). In a side analysis, standardized cancer incidence ratios (SIR) were computed separately for winegrowing communities with small, medium and large area under wine cultivation using estimated German incidence rates as refere…
Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients.
2006
Abstract Background: Impaired DNA repair capacity may favorably affect survival in cisplatin/gemcitabine-treated non-small-cell lung cancer (NSCLC) patients. We investigated the association of survival with genetic polymorphisms in X-ray repair cross-complementing group 1 and group 3 (XRCC3), xeroderma pigmentosum group D (XPD), excision repair cross-complementing group 1, ligase IV, ribonucleotide reductase, TP53, cyclooxygenase-2, interleukin-6, peroxisome proliferator-activated receptor γ, epidermal growth factor, methylene-tetra-hydrofolate reductase and methionine synthase. Patients and methods: One hundred and thirty-five stage IV or IIIB (with malignant pleural effusion) NSCLC patien…