Search results for "Lung"

Mentoring of newly qualified teachers. A bilateral comparison between Germany and Finland

2017

Mentoring stellt in der Begleitung von in den Beruf einsteigenden Lehrpersonen eine international gängige Praxis dar. Ausgehend von theoretischen und empirisch fundierten Annahmen wird in diesem Beitrag der Ansatz der practice architectures genutzt, um Formen des Mentorings in Deutschland und Finnland im Hinblick auf länderspezifische Verständnisse vom Berufseinstieg von Lehrpersonen und deren Professionalisierung zu untersuchen. (DIPF/Orig.) Internationally, mentoring is a well-recognized practice in supporting newly qualified teachers. Based on theoretical and empirical understanding, this paper compares mentoring practices in two countries: Germany and Finland. The theoretical framework …

Vidzemes Lielais Zviedru Kadastrs kā saimniecības vēstures avots

1942

Kadastrs - sistematizēti kādu zemes vai ūdens nogabalu vai citu objektu dati; ar nodokļiem apliekamo zemju saraksts un novērtējums pilsētās un laukos. Zemes kadastru sāka ar zemes uzmērīšanu un vērtēšanu, vienlaikus veicot muižu redukciju, atsavinot lielāko daļu muižas zemju, kuras nodeva Zviedrijas valsts pārziņā. Tas bija labi izstrādāts kadastrs, un to izmantoja no 1691. līdz 1911. gadam, t. i., 220 gadus. Tas pasaulē ir samērā mazpazīstams, un tagadējās Latvijas un Igaunijas teritorijā tam bija tikai lokāla nozīme. Muižu redukcija .17. gs. 2. pusē, pieaugot absolūtisma tendencēm Eiropā, Zviedrijas karalis Kārlis XI (Karl XI) centās nostiprināt varu visā valstī. Viens no pasākumiem bija …

Isolation of the Endothelin B Receptor from Bovine Lung Structure, Signal Sequence, and Binding Site

1995

Bovine lung endothelin-B receptor has been isolated in good yield with a new procedure involving the use of endothelin-1 coupled to iminobiotin with a long spacer and avidin-agarose affinity chromatography. Contrary to previous reports, evidence has been obtained that the native form of this receptor corresponds to the full-length transcript expected on the basis of cDNA clones. The binding of endothelin to a variety of shortened fragments of the full receptor suggests that the long N-terminal sequence of this receptor has very little influence on the binding of endothelin and that the main determinants of the endothelin binding site might be constituted by residues in the sixth, and possib…

Immuno-oncological treatment of Non-Small-Cell Lung Cancer (NSCLC) in advanced stage with Nivolumab

2023

Immuno-oncology marked a therapeutic revolution in the treatment of cancer. Thanks to the new strategy that aims to awaken the immune system to fight cancer cells, there has been a change in the clinical course in the treatment of advanced Non-Small Cell Lung Cancer (NSCLC). Our study aimed to evaluate the therapeutic efficacy of nivolumab monotherapy in the treatment of patients with advanced stage IIIB/IV non-small cell lung cancer beyond the second line. The results showed a progression-free survival of 7.35 months and an improvement in the quality of life of patients compared to other treatments. In addition, no type 3 and type 4 adverse reactions were detected in patients treated with …

BIOPSIA POLMONARE TC-GUIDATA STEP BY STEP

2018

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Platelet-endothelial interaction in tumor angiogenesis and microcirculation

2003

Activated platelets release angiogenic growth factors and have therefore been proposed to contribute to tumor angiogenesis within a potentially prothrombotic tumor microcirculation. The aim of the study was to investigate interactions of platelets with the angiogenic microvascular endothelium of highly vascularized solid tumors during growth and in response to endothelial stimulation in comparison with normal subcutaneous tissue. Experiments were performed in the dorsal skinfold chamber preparation of C57BL/6J mice bearing the Lewis lung carcinoma (LLC-1) or methylcholanthrene-induced fibrosarcoma (BFS-1). Fluorescently labeled rolling and adherent platelets, red blood cell velocity, and ve…

Platelets accumulate in lung lesions of tuberculosis patients and inhibit T-cell responses and Mycobacterium tuberculosis replication in macrophages

2021

: Platelets regulate human inflammatory responses that lead to disease. However, the role of platelets in tuberculosis (TB) pathogenesis is still unclear. Here, we show that patients with active TB have a high number of platelets in peripheral blood and a low number of lymphocytes leading to a high platelets to lymphocytes ratio (PL ratio). Moreover, the serum concentration of different mediators promoting platelet differentiation or associated with platelet activation is increased in active TB. Immunohistochemistry analysis shows that platelets localise around the lung granuloma lesions in close contact with T lymphocytes and macrophages. Transcriptomic analysis of caseous tissue of human …

LA BIOPSIA FULL-CORE CON DISPOSITIVI END-CUT NELLA DIAGNOSTICA DEI NODULI POLMONARI: NOSTRA ESPERIENZA COMPARATIVA CON AGHI DI DIVERSA GRANDEZZA

2018

Invitation to participate in a multi-center study for validation of cerebral computed tomography angiography and computed tomography perfusion in the…

2021

In recent years commensal microorganisms are not just “passive occupants”, but important element of homeostasis. There are numerous reports documenting the composition and role of the gut, skin or vagina microbiome but the role of commensal organisms living in the lungs is relatively unknown. Pulmonary microbiome impact on the immune response of the host organism and may indicate new therapeutic directions. Lung microbiome, by modulating the expression of innate immunity genes, causes an increase in the concentration of IL-5, IL-10, IFNγ and CCL11, affects the TLR4 dependent response of pulmonary macrophages and modulate the production of antibacterial peptides contained in the mucus. It is…

Cigarette smoke alters IL-33 expression and release in airway epithelial cells

2014

AbstractAirway epithelium is a regulator of innate immune responses to a variety of insults including cigarette smoke. Cigarette smoke alters the expression and the activation of Toll Like Receptor 4 (TLR4), an innate immunity receptor. IL-33, an alarmin, increases innate immunity Th2 responses. The aims of this study were to explore whether mini-bronchoalveolar lavage (mini-BAL) or sera from smokers have altered concentrations of IL-33 and whether cigarette smoke extracts (CSE) alter both intracellular expression (mRNA and protein) and release of IL-33 in bronchial epithelial cells. The role of TLR4 in the expression of IL-33 was also explored.Mini-BALs, but not sera, from smokers show red…