Search results for "Lung"

The non-neuronal cholinergic system

2012

Twenty Years of Basic Vocational Education Provision in Spain: Changes and Trends

2015

International journal for research in vocational education and training 2 (2015) 2, S. 137-151

Redistribution, selection, and trade

2017

Abstract This paper examines the distributional effects of international trade in a general equilibrium model with heterogeneous agents and a welfare state redistributing income. The redistribution scheme is financed by a progressive income tax and gives the same absolute transfer to all individuals. Ceteris paribus, international trade leads to an increase in income per capita but also to higher income inequality on two fronts. Inter-group inequality between managers and workers increases, and intra-group inequality within the group of managers goes up as well. We show that for a given tax rate, there is an endogenous increase in the size of the welfare state that works against the increas…

Einfühlung und Mystik in der Phänomenologie Edith Steins.

2011

Seit den Anfängen der philosophischen Spekulation – man denke etwa an Platons Alkibiades – geschieht die Reflexion des Themas des Andersseins in seiner doppelten Deklination. Auch heute übt sie noch große Faszination aus. Ich möchte die Aufmerksamkeit auf das Ineinandergreifen zwischen die Eigenerfahrung und die Fremderfahrung richten – eine Frage, die von Edith Stein schon innerhalb ihrer Doktorarbeit diskutiert wurde und dabei ähnliche Verflechtung zwischen Selbsterkenntnis und Gotteserkenntnis aufweist, wie sie die Phänomenologin infolge ihrer Augustinuslektüre, vor allem aber in Bezug auf die phänomenologische Betrachtung der mystischen Erfahrungen der Teresa von Avila und Johannes vom …

Measurement of ultra-low heating rates of a single antiproton in a cryogenic Penning trap

2019

Physical review letters 122(4), 043201 (2019). doi:10.1103/PhysRevLett.122.043201

Studies of plasma breakdown and electron heating on a 14 GHz ECR ion source through measurement of plasma bremsstrahlung

2011

Temporal evolution of plasma bremsstrahlung emitted by a 14?GHz electron cyclotron resonance ion source (ECRIS) operated in pulsed mode is presented in the energy range 1.5?400?keV with 100??s resolution. Such a high temporal resolution together with this energy range has never been measured before with an ECRIS. Data are presented as a function of microwave power, neutral gas pressure, magnetic field configuration and seed electron density. The saturation time of the bremsstrahlung count rate is almost independent of the photon energy up to 100?keV and exhibits similar characteristics with the neutral gas balance. The average photon energy during the plasma breakdown is significantly highe…

Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer.

2007

Cytotoxic chemotherapies are standard of care for patients suffering from advanced non-small cell lung cancer (NSCLC). However, objective responses are only achieved in 20% of cases and long-term survival is rarely observed. Clinically applied anticancer drugs exert at least some of their activities by inducing apoptosis. A critical step in apoptotic signal transduction is the permeabilization of the mitochondrial outer membrane (MOM), which is regulated by the BCL-2 family of proteins. Hence, therapeutic targeting of BCL-2 proteins is a promising approach to increase the drug-sensitivity of cancers. To this end we have assessed the impact of conditional expression of the proapoptotic multi…

What is the impact of rerouting a cancer diagnosis from emergency presentation to GP referral on resource use and survival? Evidence from a populatio…

2018

Background Studies on alternative routes to diagnosis stimulated successful policy interventions reducing the number of emergency diagnoses and associated mortality risk. A dearth of evidence on the costs of such interventions might prevent new policies from achieving more ambitious targets. Methods We conducted a retrospective cohort study on the population of colorectal (88,051), breast (90,387), prostate (96,219), and lung (97,696) cancer patients diagnosed after a GP referral or an emergency presentation and reported in the Cancer Registry of England. Resource use and survival were compared 1 year before and 5 years after diagnosis (3 years for lung), including the costs of GP referrals…

High resolution computed tomography quantitation of emphysema is correlated with selected lung function values in stable COPD.

2011

BACKGROUND: The literature shows conflicting results when high-resolution computed tomography (HRCT) scores of emphysema were correlated with different indices of airflow obstruction. OBJECTIVES: We correlated HRCT scores of emphysema with different indices of airflow obstruction. METHODS: We performed HRCT of the chest in 59 patients, all smokers or ex-smokers, with stable chronic obstructive pulmonary disease of different severity [GOLD stages I-IV; mean age ± SD 67.8 ± 7.3 years; pack/years 51.0 ± 34.6; percent predicted forced expiratory volume in 1 s (FEV(1)% predicted) 52.3 ± 17.6; post-bronchodilator FEV(1)% predicted 56.5 ± 19.1; FEV(1)/forced vital capacity (FVC) ratio 50.8 ± 10.2;…

Pulmonary hypertension in COPD and lung transplantation: Timing and procedures

2014

The prevalence of pulmonary hypertension (PH) in the general chronic obstructive pulmonary disease (COPD) population is undefined because stable COPD patients do not routinely undergo screening echocardiogram and right heart catheterization. Most studies published on this topic are focused on a highly selected group of patients with moderate to severe disease awaiting lung transplantation, since hemodynamic data from cardiac catheterization are part of the standard transplant evaluation. In a very recent article, Hurdman et al. studied the characteristics and outcomes, with a particular focus on mortality, of extensively phenotyped, consecutive patients with PH-COPD over a 9-year period. Th…