Search results for "Lymph node"

showing 4 items of 494 documents

The Pro-Inflammatory IL23/IL23R/IL17 Axis Is Active in IL23R-Expressing Circulating CLL Cells in Patients with Poor Prognosis

2012

Abstract Abstract 3889 Inflammatory cytokines play a biological role in the pathogenesis of Chronic lymphocytic leukemia (CLL). IL23 is a pro-inflammatory cytokine involved in T-cell responses and in tissue remodeling. It has been shown that the IL23 receptor (IL23R) is up-regulated in primary acute lymphoblastic leukemia (ALL) cells, and that IL23 inhibits ALL cell growth. Nevertheless, the anti-tumor function of IL23 still remains controversial. The role of the IL23R/IL23 axis in CLL has not been investigated so far. Herein we evaluated the expression pattern of IL23R/IL23 axis and its correlation with progression free survival (PFS) in CLL patients. A total of 233 newly diagnosed Binet s…

musculoskeletal diseasesPathologymedicine.medical_specialtyChronic lymphocytic leukemiaImmunologyContext (language use)Cell BiologyHematologyCD38Biologymedicine.diseaseBiochemistrymedicine.anatomical_structureAcute lymphocytic leukemiamedicineImmunohistochemistryBone marrowProgression-free survivalLymph nodeBlood
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Lymphatic vessels of the dura mater: a new discovery?

2015

Aspelund et al. discover the presence of a lymphatic vessel network in the dura mater of the mouse brain and show that these dural lymphatic vessels are important for the clearance of macromolecules from the brain.

musculoskeletal diseasesPathologymedicine.medical_specialtyHistologyMacromolecular SubstancesDura materCentral nervous systemNeuroimmunologyBlood–brain barrierBlood-brain barrier; Brain; Central nervous system; Dura mater; Lymphatics; Mascagni; Neuroanatomy; Neuroimmunology; Transudate; Anatomy; Histology; Developmental Biology; Ecology Evolution Behavior and Systematics; Molecular Biology; Cell BiologyTransudateLymphatic SystemMatters ArisingmedicineAnimalsDura materMolecular BiologyEcology Evolution Behavior and SystematicsBlood-brain barrierCerebrospinal Fluidintegumentary systembusiness.industrySettore BIO/16 - Anatomia UmanaBrief Definitive ReportMascagniBrainExtracellular FluidAnatomyCell Biologymusculoskeletal systemEcology Evolution Behavior and SystematicTransudatenervous system diseasesNeuroanatomyNeuroimmunologymedicine.anatomical_structureLymphatic systemnervous systemCentral nervous systemLymph NodesAnatomybusinessLymphaticNeuroanatomyDevelopmental BiologyJournal of anatomy
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Comparison of 99mTc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis

2020

We compared the detection rate (DR) for sentinel lymph nodes (SLNS), the number of SLNs and the subjects with additional SLNs of single-photon emission computed tomography (SPECT/CT) and planar lymphoscintigraphy (PL) in patients with melanoma. Furthermore, we evaluated the impact of SPECT/CT on surgical plans. Articles containing head-to-head comparisons between SPECT/CT and PL were searched in Pubmed/MEDLINE and Scopus. The literature search was updated until December 31st, 2019. DR was calculated on a per-patient-based analysis; the studies were pooled by their odds ratios (ORs) with a random effects model to assess the significance of difference (p < 0.05). The number of additional S…

planar lymphoscintigraphySentinel lymph nodelcsh:MedicineSingle-photon emission computed tomography030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicinesentinel lymph node99mTc-labeled colloidsmedicinemelanomamedicine.diagnostic_testbusiness.industryMelanomalcsh:RGeneral MedicineOdds ratiomedicine.diseaseConfidence intervalbody regionsmeta-analysis<sup>99m</sup>Tc-labeled colloids030220 oncology & carcinogenesisRelative riskMeta-analysis99mTc-labeled colloids; melanoma; meta-analysis; planar lymphoscintigraphy; sentinel lymph node; single photon emission/computed tomographysingle photon emission/computed tomographyNuclear medicinebusinessEmission computed tomographyJournal of Clinical Medicine
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Vascularized lymph node transfer for treatment of extremity lymphedema: An overview of current controversies regarding donor sites, recipient sites a…

2018

As lymphatic microsurgery has become more common, vascularized lymph node transfer ascended to the forefront in many centers for the surgical management of advanced stages of lymphedema showing substantial clinical improvement. However, no consensus has been reached among experts regarding many details of the procedures, including patient selection criteria, type of treatment, donor, and recipient sites and postoperative evaluation of the outcome. Here, we will review these issues and provide the current results of this procedure.

vascularized lymph node transfer lymphedema lymphatic microsurgerymedicine.medical_specialtymedicine.medical_treatmentTreatment outcome030230 surgery03 medical and health sciences0302 clinical medicinemedicineHumansLymphedemaLymph nodebusiness.industryGeneral surgeryAdvanced stageExtremitiesGeneral MedicineMicrosurgerymedicine.diseaselymphatic microsurgery; lymphedema; vascularized lymph node transfer; Humans; Lymph Nodes; Lymphedema; Treatment Outcome; ExtremitiesLymphatic systemLymphedemamedicine.anatomical_structureTreatment OutcomeOncology030220 oncology & carcinogenesisSurgeryLymph NodesbusinessJournal of surgical oncology
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