Search results for "M15"
showing 10 items of 21 documents
Stochastic Galerkin method for cloud simulation
2018
AbstractWe develop a stochastic Galerkin method for a coupled Navier-Stokes-cloud system that models dynamics of warm clouds. Our goal is to explicitly describe the evolution of uncertainties that arise due to unknown input data, such as model parameters and initial or boundary conditions. The developed stochastic Galerkin method combines the space-time approximation obtained by a suitable finite volume method with a spectral-type approximation based on the generalized polynomial chaos expansion in the stochastic space. The resulting numerical scheme yields a second-order accurate approximation in both space and time and exponential convergence in the stochastic space. Our numerical results…
Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel Metalloprotease Substrates
2021
Ectodomain shedding is a key mechanism of several biological processes, including cell-communication. Disintegrin and metalloproteinases (ADAMs), together with the membrane-type matrix metalloproteinases, play a pivotal role in shedding transmembrane proteins. Aberrant shedding is associated to several pathological conditions, including arthritis. Tissue inhibitor of metalloproteases 3 (TIMP-3), an endogenous inhibitor of ADAMs and matrix metalloproteases (MMPs), has been proven to be beneficial in such diseases. Thus, strategies to increase TIMP-3 bioavailability in the tissue have been sought for development of therapeutics. Nevertheless, high levels of TIMP-3 may lead to mechanism-based …
TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1
2017
Eukaryotic cell cycle progression through G(1)-S is driven by hormonal and growth-related signals that are transmitted by the target of rapamycin complex 1 (TORC1) pathway. In yeast, inactivation of TORC1 restricts G(1)-S transition due to the rapid clearance of G(1) cyclins (Cln) and the stabilization of the B-type cyclin (Clb) cyclin-dependent kinase (CDK) inhibitor Sic1. The latter mechanism remains mysterious but requires the phosphorylation of Sic1-Thr(173) by Mpk1 and inactivation of the Sic1-pThr(173)-targeting phosphatase (PP2A(Cdc55)) through greatwall kinase-activated endosulfines. Here we show that the Sic1-pThr(173) residue serves as a specific docking site for the CDK phospho-a…
Three-page encoding and complexity theory for spatial graphs
2004
We construct a series of finitely presented semigroups. The centers of these semigroups encode uniquely up to rigid ambient isotopy in 3-space all non-oriented spatial graphs. This encoding is obtained by using three-page embeddings of graphs into the product of the line with the cone on three points. By exploiting three-page embeddings we introduce the notion of the three-page complexity for spatial graphs. This complexity satisfies the properties of finiteness and additivity under natural operations.
MOLECULAR CHARACTERIZATION OF MULTIDRUG-RESISTANT E. COLI ISOLATED FROM BACTEREMIA PATIENTS
2014
Background: Extraintestinal pathogenic Escherichia coli (ExPEC) bacteria have the ability to cause diverse and serious diseases, such as urinary tract infections (UTIs) and bacteremia; incidence of bacteremia is increasing globally. The emergence of multidrug resistance in E. coli is also becoming a global concern, with particular emphasis on E. coli sequence type (ST) 131, which is being increasingly reported in UTIs. Drug resistance is mediated by extended- spectrum β-lactamases (ESBLs), mainly of the CTX-M family, particularly CTX-M-15, and less frequently of the SHV and OXA families. Few studies are available regarding the characterization of E. coli strains causing bacteremia. Methods:…
An upper echelons perspective on information technology business value
2017
This paper argues that information technology (IT) outcomes are more valuable to companies when their top management team (TMT) moves from flirting with IT to marriage. Previous research has demonstrated an association between top management support (TMS) and IT value. We extend the concept of TMS with the imbrication metaphor to define the construct of TMT-IT imbrication, which allows us to account for a tighter and continuous entwining of the TMT and IT to create IT value. Our definition of the TMT-IT imbrication construct embraces four dimensions: involvement, participation, attention, and use. In addition, with the support of upper echelons (UE) theory, we explore certain managerial tra…
All that glitters is not gold. The rise of gaming in the COVID-19 pandemic
2020
Abstract The COVID-19 pandemic has led to an unprecedented situation, with incalculable health, social, and economic consequences. At the start of the outbreak, the financial markets collapsed, although not all sectors suffered equally. The gaming and eSports industry is one of those that has suffered the least from the fall in the markets. Millions of people locked up at home, bored, stressed, and anguished, gave gaming and eSports companies growing prominence throughout the first half of 2020. This prominence has elicited interest in analyzing which variables can influence the returns in an industry in better financial health than many others. Using a logit–probit model, this research aim…
Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans
2013
Brotherton, Paul et al.-- The Genographic Consortium
Algebraic groups as difference Galois groups of linear differential equations
2019
We study the inverse problem in the difference Galois theory of linear differential equations over the difference-differential field $\mathbb{C}(x)$ with derivation $\frac{d}{dx}$ and endomorphism $f(x)\mapsto f(x+1)$. Our main result is that every linear algebraic group, considered as a difference algebraic group, occurs as the difference Galois group of some linear differential equation over $\mathbb{C}(x)$.
The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response
2012
ABSTRACT Natural killer (NK) cells and CD8 + T cells play a prominent role in the clearance of mouse cytomegalovirus (MCMV) infection. The role of NK cells in modulating the CD8 + T-cell response to MCMV infection is still the subject of intensive research. For analyzing the impact of NK cells on mounting of a CD8 + T-cell response and the contribution of these cells to virus control during the first days postinfection (p.i.), we used C57BL/6 mice in which NK cells are specifically activated through the Ly49H receptor engaged by the MCMV-encoded ligand m157. Our results indicate that the requirement for CD8 + T cells in early MCMV control inversely correlates with the engagement of Ly49H. W…