Search results for "M1"
showing 10 items of 837 documents
A remark on hyperplane sections of rational normal scrolls
2017
We present algebraic and geometric arguments that give a complete classification of the rational normal scrolls that are hyperplane section of a given rational normal scrolls.
Caffeic acid skin absorption: Delivery of microparticles to hair follicles
2019
Graphical abstract: Emulsions containing CA were prepared, one of which contain free CA and the other microencapsulated CA. They were applied to delimited area of skin. Subsequently the tape stripping and differential striping methods were applied.
Pharmacologic Inhibition of ADAM10 Attenuates Brain Tissue Loss, Axonal Injury and Pro-inflammatory Gene Expression Following Traumatic Brain Injury …
2021
The α-secretase A disintegrin and metalloprotease 10 (ADAM10) regulates various physiological and pathophysiological processes. Despite its broad functional implications during development, plasticity, and disease, no pharmacological approaches to inhibit ADAM10 in acute brain injury have been reported. Here, we examined the effects of the ADAM10 inhibitor GI254023X on the neurological and histopathological outcome after experimental traumatic brain injury (TBI). C57BL/6N mice were subjected to the controlled cortical impact (CCI) model of TBI or sham procedure and received GI254023X or vehicle during the acute phase of injury (n = 40, 100 mg/kg, 25% DMSO, 0.1 M Na2CO3, intraperitoneal, 30 …
Competence Utilization for Innovation Capabilities - A Question of Trust?
2015
The purpose of this paper is to show how trust as an organizational value contributes to employee competence utilization in the case of innovation capability. Thus, it is the objective of this paper to analyze the positive impacts, but also potential limits of trust in business management. The research paper uses two different quantitative empirical studies drawn from German and Austrian mid-sized companies to empirically test this interrelation. As a result, the paper determines particular aspects of trust such as accountability, shared norms and the ability to take responsibility to be interrelated with the usage of employee competences and underlines a positive connection between product…
FLT3 y NPM1 como marcadores moleculares en la leucemia mieloblástica aguda. Utilidad pronóstica y diagnóstica.
2015
La Leucemia Mieloblástica Aguda (LMA) es una neoplasia clonal del tejido hematopoyético caracterizada por la proliferación de células blásticas anormales de estirpe mieloide en la médula ósea. El conocimiento de las alteraciones genéticas en la LMA, principalmente translocaciones cromosómicas, ha permitido establecer grupos de riesgo y conocer el pronóstico de los mismos. Sin embargo, existe una importante proporción de pacientes, en torno al 40-50%, que no pueden ser estratificados en base a estas alteraciones, debido a que presentan cariotipos sin ninguna anomalía citogenética, haciendo necesario en este grupo, denominado como LMA de riesgo intermedio, la búsqueda de biomarcadores que ayu…
Ubiquitin conjugating enzyme E2-N and sequestosome-1 (p62) are components of the ubiquitination process mediated by the malin-laforin E3-ubiquitin li…
2015
11 páginas, 9 figuras.
P3‐335: Upstream of N‐ras (UNR) is involved in translational control of ADAM10 protein expression
2008
Background: The amyloid beta peptide (A ) is derived by proteolytic processing of the amyloid precursor protein (APP) by the beta-secretase BACE1 and gamma-secretase. In contrast to this amyloidogenic processing, APP is predominantly cleaved by the alpha-secretase within the A domain and this precludes the formation of A . We and other research groups could show that BACE1 protein expression is regulated by the 5’untranslated region (UTR) of the BACE1 mRNA, however little is known about the regulation of alpha-secretase. Similar to the 5’UTR of BACE1, the 5’UTR of ADAM10 consists of 444 nucleotides with a GC-content of 70% and two upstream open reading frames. We hypothesize that ADAM10, th…
Governance of global value chains after the Covid-19 pandemic: A new wave of regionalization?
2021
The disruption of the trade and investment activities of multinational enterprises as a consequence of the Covid-19 pandemic has reinvigorated the debate on the configuration of global value chains (GVCs) as well as the risks and challenges associated with offshoring. This article depicts how the pandemic might affect GVC configuration by driving a trend toward a more regional footprint in industries in which resilience and reliability are critical. Such a shift would create new opportunities for reshoring, and affect both the types of upgrading trajectories and the governance systems in value chains. The article also draws from the intersection of the global-strategy and value-chain field…
On double Veronese embeddings in the Grassmannian G(1,N)
2004
We classify all the embeddings of P^n in a Grassmannian of lines G(1,N) such that the composition with Pl\"ucker is given by a linear system of quadrics of P^n.
Changes in atmospheric pollutants during COVID-19
2022
Bakalaura darba “Atmosfēras piesārņojuma izmaiņas COVID-19 laikā” mērķis –Identificēt un izpētīt ar COVID-19 pandēmiju saistītās izmaiņas, konkrēti, pārvietošanās ierobežojumu un dzīves veida izmaiņu, ietekmi attiecībā uz atmosfēras piesārņojuma koncentrāciju rādītājiem Latvijas Republikas galvaspilsētā Rīgā. Pētījumā analizēti dati no Latvijas Ģeoloģijas un Meteoroloģijas (LVĢMC) centra novērojumu stacijām. COVID-19 pandēmijas ietekme bija jūtama visā pasaulē, tostarp arī Eiropā, jo ārkārtas stāvokļa un pārvietošanās ierobežojumu rezultātā bija vērojamas izmaiņas emisiju dinamikā atmosfērā. Sakarā ar izmaiņām darba norisē un darbinieku pāreju uz attālināto darbu, kā arī mācību un studiju p…