Search results for "M1"

Early attraction in temporally controlled sight reading of music

2018

A music reader has to “look ahead” from the notes currently being played—this has usually been called the Eye-Hand Span. Given the restrictions on processing time due to tempo and meter, the Early Attraction Hypothesis suggests that sight readers are likely to locally increase the span of looking ahead in the face of complex upcoming symbols (or symbol relationships). We argue that such stimulus-driven effects on looking ahead are best studied using a measure of Eye-Time Span (ETS) which redefines looking ahead as the metrical distance between the position of a fixation in the score and another position that corresponds to the point of metrical time at fixation onset. In two experiments of …

FRUIT INHIBITS FLOWERING IN ALTERNATE BEARING CITRUS VARIETIES. HORMONAL, GENETIC AND EPIGENETIC REGULATION

In mature citrus trees, flowering is regulated by exogenous signals (i.e., low/high temperature, water shortage/water supply) that control flowering time, and by endogenous signals that control flower intensity. Actually, the ratio of endogenous promoters to inhibitors is considered as responsible for flowering; however, there is evidence suggesting that the inhibitors and their metabolism are the sole factors controlling flowering in Citrus. All the meristems have the information and ability to flower unless a negative factor hampers the process. The main endogenous factor controlling flower intensity is the fruit. Attending to the aforementioned, in this PhD. thesis, the following hypothe…

The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid…

2021

Gut microbiota plays a key role in obesity and non-alcoholic fatty liver disease (NAFLD), so synbiotics could be a therapeutic alternative. We aim to evaluate a nutritional intervention together with the administration of the bacteria Akkermansia muciniphila and the antioxidant quercetin in an in vivo model of early obesity and NAFLD. 21-day-old rats were fed with control or high-fat diet for six weeks. Then, all animals received control diet supplemented with/without quercetin and/or A. muciniphila for three weeks. Gut microbiota, NAFLD-related parameters, circulating bile acids (BAs) and liver gene expression were analyzed. The colonization with A. muciniphila was associated with less bod…

Protective Effects of a Discontinuous Treatment with Alpha-Lipoic Acid in Obesity-Related Heart Failure with Preserved Ejection Fraction, in Rats

2020

Obesity induces hemodynamic and humoral changes that are associated with functional and structural cardiac remodeling, which ultimately result in the development of heart failure (HF) with preserved ejection fraction (HFpEF). In recent years, pharmacological studies in patients with HFpEF were mostly unsatisfactory. In these conditions, alternative new therapeutic approaches are necessary. The aim of our study was (1) to assess the effects of obesity on heart function in an experimental model and (2) to evaluate the efficacy of an alpha-lipoic acid (ALA) antioxidant treatment. Sprague-Dawley rats (7 weeks old) were either included in the control group (n = 6) or subjected to abdominal aorti…

Olfactory and cortical projections to bulbar and hippocampal adult-born neurons

2015

New neurons are continually generated in the subependymal layer of the lateral ventricles and the subgranular zone of dentate gyrus during adulthood. In the subventricular zone, neuroblasts migrate a long distance to the olfactory bulb where they differentiate into granule or periglomerular interneurons. In the hippocampus, neuroblasts migrate a short distance from the subgranular zone to the granule cell layer of the dentate gyrus to become granule neurons. In addition to the short-distance inputs, bulbar interneurons receive long-distance centrifugal afferents from olfactory-recipient structures. Similarly, dentate granule cells receive differential inputs from the medial and lateral ento…

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor {kappa}B.

2009

Cells of the monocyte-macrophage lineage play a central role in the orchestration and resolution of inflammation. Plasticity is a hallmark of mononuclear phagocytes, and in response to environmental signals these cells undergo different forms of polarized activation, the extremes of which are called classic or M1 and alternative or M2. NF-kappaB is a key regulator of inflammation and resolution, and its activation is subject to multiple levels of regulation, including inhibitory, which finely tune macrophage functions. Here we identify the p50 subunit of NF-kappaB as a key regulator of M2-driven inflammatory reactions in vitro and in vivo. p50 NF-kappaB inhibits NF-kappaB-driven, M1-polariz…

Dietary water seems to improve skin hydration without influencing hemodynamics

2013

The various studies on the importance of water in the hydration of human skin have suggested that an increased dietary intake might positively impact the physiology of normal skin. We evaluated the consequences of increasing water intake through drinking in skin hydration in vivo. Eating habits were maintained, evaluated by a Food Frequency Questionnaire and based on total water consumption. In two groups with different total water consumption, we evaluated the impact of 2L/day water after 30 days,. This increase produced no hemodynamic changes or weight changes but an improvement in the epidermal hydration was suggested. The magnitude of the impact on skin hydration was higher in the group…

Stromal Interaction Molecule 1 (STIM1) Is Involved in the Regulation of Mitochondrial Shape and Bioenergetics and Plays a Role in Oxidative Stress

2012

Calcium ions are involved in a plethora of cellular functions including cell death and mitochondrial energy metabolism. Store-operated Ca(2+) entry over the plasma membrane is activated by depletion of intracellular Ca(2+) stores and is mediated by the sensor STIM1 and the channel ORAI1. We compared cell death susceptibility to oxidative stress in STIM1 knock-out and ORAI1 knockdown mouse embryonic fibroblasts and in knock-out cells with reconstituted wild type and dominant active STIM1. We show that STIM1 and ORAI1 deficiency renders cells more susceptible to oxidative stress, which can be rescued by STIM1 and ORAI1 overexpression. STIM1 knock-out mitochondria are tubular, have a higher Ca…

Institucions jurídiques de la Unió Europea

2018

El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València tema 1 i tema 2 del programa de la assignatura "institucions jurídiques de la unió europea", de la facultat de dret (universitat de valència) programme: m1 t1 t2. subjet "european union legal institutions" studied at the faculty of law (univresity of valència)

The Administration of Escherichia coli Nissle 1917 Ameliorates Development of DSS-Induced Colitis in Mice

2018

The beneficial effects of probiotics on immune-based pathologies such as inflammatory bowel disease (IBD) have been well reported. However, their exact mechanisms have not been fully elucidated. Few studies have focused on the impact of probiotics on the composition of the colonic microbiota. The aim of the present study was to correlate the intestinal anti-inflammatory activity of the probiotic Escherichia coli Nissle 1917 (EcN) in the dextran sodium sulfate (DSS) model of mouse colitis with the changes induced in colonic microbiota populations. EcN prevented the DSSinduced colonic damage, as evidenced by lower disease activity index (DAI) values and colonic weight/length ratio, when compa…