Search results for "M50"
showing 10 items of 141 documents
Derivation of a Homogenized Two-Temperature Model from the Heat Equation
2014
This work studies the heat equation in a two-phase material with spherical inclusions. Under some appropriate scaling on the size, volume fraction and heat capacity of the inclusions, we derive a coupled system of partial differential equations governing the evolution of the temperature of each phase at a macroscopic level of description. The coupling terms describing the exchange of heat between the phases are obtained by using homogenization techniques originating from [D. Cioranescu, F. Murat: Coll\`ege de France Seminar vol. 2. (Paris 1979-1980) Res. Notes in Math. vol. 60, pp. 98-138. Pitman, Boston, London, 1982.]
Dynamic clonal remodelling in breast cancer metastases is associated with subtype conversion
2019
Background: Changes in the clinical subtype (CS) and intrinsic subtype (IS) between breast cancer (BC) metastases and corresponding primary tumours have been reported. However, their relationship with tumour genomic changes remains poorly characterised. Here, we analysed the association between genomic remodelling and subtype conversion in paired primary and metastatic BC samples. Methods: A total of 57 paired primary and metastatic tumours from GEICAM/2009-03 (ConvertHER, NCT01377363) study participants with centrally assessed CS (n = 57) and IS (n = 46) were analysed. Targeted capture and next-generation sequencing of 202 genes on formalin-fixed paraffin-embedded samples was performed. Th…
A Pathology-Based Combined Model to Identify PAM50 Non-luminal Intrinsic Disease in Hormone Receptor-Positive HER2-Negative Breast Cancer
2019
No luminal; Subtipus intrínsec; Càncer de mama No luminal; Subtipo intrínseco; Cáncer de mama Non-luminal; Intrinsic subtype, Breast cancer Background: In hormone receptor-positive (HR+)/HER2-negative breast cancer, the HER2-enriched and Basal-like intrinsic subtypes are associated with poor outcome, low response to anti-estrogen therapy and high response to chemotherapy. To date, no validated biomarker exists to identify both molecular entities other than gene expression. Methods: PAM50 subtyping and immunohistochemical data were obtained from 8 independent studies of 1,416 HR+/HER2-negative early breast tumors. A non-luminal disease score (NOLUS) from 0 to 100, based on percentage of estr…
Outcomes of single versus double hormone receptor–positive breast cancer. A GEICAM/9906 sub-study
2018
Abstract Background Retrospective data suggest better outcomes for patients with double hormonal receptor (oestrogen [ER] and progesterone receptor [PgR])–positive (dHR+) early breast cancer, compared with single hormonal receptor–positive, sHR+, (ER+/PgR– or ER–/PgR+) disease. Here, we evaluate the classification according to intrinsic subtypes and clinical outcomes of sHR+ versus dHR+ in HER2-negative breast cancer patients enrolled in GEICAM/9906 study ( NCT00129922 ). Methods Archival tumours were retrieved retrospectively for the analysis of ER, PgR and HER2 status and classified into intrinsic subtypes using the PAM50 gene expression assay. Disease-free survival (DFS) and overall surv…
The relevance of corporate social responsibility for a sustainable human resource management: An analysis of organizational attractiveness as a deter…
2012
Corporate Social Responsibility (CSR) has become a central issue of business management in recent years. This study aims to add to the literature by pointing out the relevance of CSR for a Sustainable Human Resource Management (HRM). In particular this research investigates job seekers’ perceptions of CSR. The paper focuses on the importance of CSR with in the process of selecting potential employers by analyzing the impact of four different CSR-dimensions upon organizational attractiveness. To address this issue, a policy-capturing study was conducted. Generally the paper provides evidence that each aspect of CSR has a specific effect on organizational attraction. Referring to Sustainable …
On hyperbolic type involutions
2001
We give a bound on the number of hyperbolic knots which are double covered by a fixed (non hyperbolic) manifold in terms of the number of tori and of the invariants of the Seifert fibred pieces of its Jaco-Shalen-Johannson decomposition. We also investigate the problem of finding the non hyperbolic knots with the same double cover of a hyperbolic one and give several examples to illustrate the results.
Integrability of the one dimensional Schrödinger equation
2018
We present a definition of integrability for the one dimensional Schroedinger equation, which encompasses all known integrable systems, i.e. systems for which the spectrum can be explicitly computed. For this, we introduce the class of rigid functions, built as Liouvillian functions, but containing all solutions of rigid differential operators in the sense of Katz, and a notion of natural boundary conditions. We then make a complete classification of rational integrable potentials. Many new integrable cases are found, some of them physically interesting.
Employee Satisfaction Measurement – Part of Internal Marketing
2012
Since 1980 service companies have realized that standards and technology are essential for the successful implementing of the adopted strategy, but not enough. Without employees with the proper attitude, knowledge and skills, strategy can not generate the desired results. Great service companies highlight that employees (front-line employees) are responsible for the implementation of the service strategy, their satisfaction and loyalty having a direct and strong influence on the satisfaction and loyalty of the customers. In this context, this paper aims to highlight the importance of employees in delivering reliable services, as well as how to measure employee satisfaction levels. Regarding…
E-learning in corporate training using interactive courses
2017
Master's thesis Multimedia and Educational Technology MM500 - University of Agder 2017 Health, safety, and environment (HSE) is an important term in industrial- and corporate context. A company focusing on their employees sharing the same values and attitudes regarding HSE can experience a working environment where employees feels safe, and perform their work without unnecessary risk-taking. There are often seen examples where HSE training relies on traditional classroom teaching, and keeps the focus on “do’s and “don’ts”, but the key to get employees to share a common goal on HSE, is to provide a deeper meaning for each employee on what this term actually mean. The purpose of this research…
Utvikling, testing og evaluering av en videobasert læringsressurs for selvstyrt bedriftsopplæring : En casestudie fra Posten Norge AS
2017
Masteroppgave Multimedia and Educational Technology MM500 - Universitetet i Agder 2017 Opplæring av ansatte er arbeidsgivers plikt og arbeidstakers rett, og er derfor en sentral del ved ethvert arbeidsforhold. Ansattes mulighet for utvikling og innflytelse i egen arbeidssituasjon har også vist seg å være fundamentale drivere for engasjement på arbeidsplassen. I samsvar med den teknologiske utviklingen muliggjør det for design av effektive læringsressurser som kan bidra med å tilgjengeliggjøre læringsmateriell, og på samme tid være med på å engasjere ansatte ved gjennomføring av bedriftsopplæring. I nåværende opplæringssituasjon i Posten Norge AS er det kun én metode for opplæring av postbud…