Search results for "MAC"
showing 10 items of 24950 documents
Pharmacokinetics of new oral anticoagulants: implications for use in routine care
2018
Introduction: Since 2008, new oral anticoagulants (NOACs) have been approved for the prevention of venous thromboembolism (VTE) in patients receiving hip or knee replacement surgery, prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF), treatment of deep vein thrombosis (DVT), and pulmonary embolism (PE). Premarketing randomized clinical trials (RCTs) of NOACs demonstrated their non-inferiority in terms of efficacy vs. warfarin (traditional oral anticoagulant–TOA), with lower risk of serious adverse drug reactions, especially cerebral hemorrhages. In clinical practice, pharmacokinetic aspects of NOACs have to be carefully taken into account to …
Impact of Glucose-Lowering Medications on Cardiometabolic Risk in Type 2 Diabetes
2019
Type 2 Diabetes Mellitus (T2DM) is associated with a high risk of atherosclerotic cardiovascular (CV) disease. Contributing pathophysiologic factors include endothelial dysfunction caused by excessive production of reactive oxygen species (ROS), increased activity of nuclear factor kB (NFkB), altered macrophage polarization, and reduced synthesis of endothelial progenitor cells (EPC). Consequently, there can be a potentially rapid progression of the atherosclerotic disease with a higher propensity to unstable plaque, leading to increased cardiovascular mortality. Management is aimed at prevention, early diagnosis, and treatment of hyperglycemia and vascular complications. Innovative therape…
Genetic features of Multi Drug Resistant (MDR) Klebsiella pneumoniae and its Plasmids
2019
Klebsiella pneumoniae, a major cause of both hospital and community-acquired infections, is listed by the World Health Organization as a critical priority antibiotic- resistant bacterial pathogen. With the appearance of sequencing techniques such as Next-generation Sequencing (NGS), there is the possibility to obtain the whole genome of the bacteria, getting to know all antimicrobial resistance determinants. The purpose of this study has been to apply this new technology to clinical microbiology, in order to characterize the resistome present in carbapenem-resistant K.pneumoniae strains isolated in a tertiary hospital in Valencia, Spain. A total of 234 isolates were prepared for whole-genom…
Endofenotipos neurocognitivos potenciales para el trastorno bipolar: velocidad motora manual, memoria visual, velocidad de procesamiento
2017
Antecedentes: Son pocas las investigaciones que se centran en el estudio de las disfunciones neurocognitivas en pacientes con trastorno bipolar (TB) como posibles marcadores de rasgo para esta enfermedad, menos aún son las que comparan el rendimiento motor, la memoria visual o la velocidad de procesamiento de la información, en estudios transversales o longitudinales, incluyendo a la vez, controles (CS) y familiares sanos de primer grado de los pacientes (TB-F); hasta la redacción de esta tesis, aunque el número va en aumento, en la investigación psiquiátrica el trastorno bipolar sigue ocupando un lugar secundario frente a la esquizofrenia, siendo insuficientes los estudios que buscan evide…
Efectos de la modulación colinérgica y la administración de R-(+)-8-OH-DPAT sobre la evitación inhibitoria a lo largo del ciclo vital en ratones
2015
Las sustancias que actúan modulando los sistemas de neurotrasmisión colinérgico y serotoninérgico, como algunos antidepresivos, han demostrado en estudios previos un efecto deteriorante o facilitador en el aprendizaje y memoria de la tarea de evitación inhibitoria en roedores. Este trabajo tuvo como objetivo el investigar el papel que los sistemas de neurotrasmisión colinérgico y serotoninérgico a través de la administración de diferentes sustancias juegan en la consolidación del aprendizaje de evitación inhibitoria a lo largo de tres etapas del ciclo vital de ratones machos y hembras. Para ello se emplearon fármacos más específicos que interfieren en estos dos sistemas para analizar el efe…
La televisión de la sociedad democrática: ¿Una necesidad imposible?
2004
Inorganic Mercury Sequestration by a Poly(ethylene imine) Dendrimer in Aqueous Solution
2015
The interaction of the G-2 poly(ethylene imine) dendrimer L, derived from ammonia as initiating core, with Hg(II) and HgCl4 2− was studied in aqueous solution by means of potentiometric (pH-metric) measurements. Speciation of these complex systems showed that L is able to form a wide variety of complexes including 1:1, 2:1, 3:1 and 3:2 metal-to-ligand species, of different protonation states, as well as the anion complexes ((H7L)HgCl4) 5+ and ((H8L)HgCl4) 6+ . The stability of the metal complexes is very high, making L an excellent sequestering agent for Hg(II), over a large pH range, and a promising ligand for the preparation of functionalized activated carbons to be employed in the remedi…
Autorytarna merytokracja — zarys modeluijego legitymizacja na przykładzie Chin
2021
The article analyses the model of authoritarian meritocracy and its legitimisation on the example of the Chinese People’s Republic. The discussed model is based on three principles: 1. power is exercised by a monoparticle elite that legitimises its position on the basis of moral and substantive criteria; 2. patriarchal and anti-democratic governance; 3. the authorities’ policy aims to meet the material needs of citizens, but without granting them political rights. The Communist Party of China in its official narrative, on the one hand, refers to the assumptions of Maoism, but on the other hand, to a much greater extent — especially in the field of economic cases and the operation of the adm…
Scholarly publishing depends on peer reviewers
2018
The peer-review crisis is posing a risk to the scholarly peer-reviewed journal system. Journals have to ask many potential peer reviewers to obtain a minimum acceptable number of peers accepting reviewing a manuscript. Several solutions have been suggested to overcome this shortage. From reimbursing for the job, to eliminating pre-publication reviews, one cannot predict which is more dangerous for the future of scholarly publishing. And, why not acknowledging their contribution to the final version of the article published? PubMed created two categories of contributors: authors [AU] and collaborators [IR]. Why not a third category for the peer-reviewer? published
Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature, and immunohistochemical analysis.
2007
Oral melanoacanthoma (MA) is a rare, benign pigmented lesion, similar to cutaneous MA, characterized by hyperplasia of spinous keratinocytes and dendritic melanocytes. The pathogenesis of oral MA remains uncertain, although its clinical behavior is suggestive of a reactive origin. The most common intraoral sites are the buccal mucosa, lip, palate and gingiva. The average age of presentation is 28 years, mainly in blacks, with a strong female predilection. The oral melanotic macule (MM) is a small, well-circumscribed brown-to-black macule that occurs on the lips and mucous membranes. The etiology is not clear and it may represent a physiologic or reactive process. The average age of presenta…