Search results for "MACRO"

Differential Roles of Macrophages in Diverse Phases of Skin Repair

2010

Abstract Influx of macrophages plays a crucial role in tissue repair. However, the precise function of macrophages during the healing response has remained a subject of debate due to their functional dichotomy as effectors of both tissue injury and repair. We tested the hypothesis that macrophages recruited during the diverse phases of skin repair after mechanical injury exert specific functions to restore tissue integrity. For this purpose, we developed a mouse model that allows conditional depletion of macrophages during the sequential stages of the repair response. Depletion of macrophages restricted to the early stage of the repair response (inflammatory phase) significantly reduced the…

La transizione energetica sostenibile: scenari per un'economia a basse emissioni di carbonio

2016

Expanding Research Capacity at United States Universities: a Study of Academic Research and Development Investment from 1990-2005

2012

Growing emphasis has been placed on universities to contribute to the innovation process and as a result academic research and development expenditures have increased in recent years. Nevertheless, little is known about the specific ways in which universities have expanded their research capacity.This paper examines how universities in the United States (US) have expanded research capacity as research funding has increased. Specifically, it identifies what type of research infrastructure, including various categories of human capital and research equipment, are most closely associated with increased academic research funding. Using data from 375 US universities spanning the period 1990‐2005…

Using GATS Article II to Resort to Investment Arbitration

2020

It is widely known that links between international investment law and World Trade Organization (WTO) rules—which are part of competition law at the global level—are numerous. But is it possible to use a WTO rule to resort to investment arbitration? This is what a corporation from Luxembourg attempted to do recently as a consequence of a dispute arising from an investment made in the airport sector in Senegal. Since Luxembourg had no investment treaty with the investor’s host state, the claimant sought to establish the jurisdiction of an investment tribunal by combining the most-favoured-nation clause provided in General Agreement on Trade in Services (GATS) Article II and the investor-stat…

Longitudinal analysis of Mycobacterium tuberculosis 19-kDa antigen-specific T cells in patients with pulmonary tuberculosis: association with disease…

2003

CD8(+) T cells play a central role in immune protection against infection with Mycobacterium tuberculosis. One of the target epitopes for anti-M. tuberculosis directed CD8(+) T cells is the HLA-A2-restricted 19-kDa lipoprotein peptide VLTDGNPPEV. T cell clones directed against this epitope recognized not only the nominal peptide ligand, but also a closely related peptide (VPTDPNPPEV) from the HIV envelope gp120 (HIV(env) gp120) protein characterized by IFN-gamma release. This cross-reactivity was confirmed in ex vivo in M. tuberculosis 19-kDa tetramer-sorted T cells from patients with tuberculosis and in HIVgp120 tetramer-reactive T cells sorted from HIV(+) patients. M. tuberculosis 19-kDa …

Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a n…

2007

Abstract Toll IL-1R 8/single Ig IL-1-related receptor (TIR8/SIGIRR) is a member of the IL-1R family, expressed by epithelial tissues and immature dendritic cells, and is regarded as a negative regulator of TLR/IL-1R signaling. Tir8-deficient mice were rapidly killed by intranasal administration of low doses of Mycobacterium tuberculosis, despite controlling efficiently the number of viable bacilli in different organs. Tir8−/−-infected mice showed an increased number of neutrophils and macrophages in the lungs; however, mycobacteria-specific CD4 and CD8 T cells were similar in Tir8−/− and Tir8+/+ mice. Exaggerated mortality of Tir8−/− mice was due to massive liver necrosis and was accompanie…

IL-4 depletion enhances host resistance and passive IgA protection against tuberculosis infection in BALB/c mice.

2007

The influence of Th2 cytokines in tuberculosis has been a matter of dispute. Here we report that IL-4 has a profound regulatory effect on the infection of BALB/c mice with Mycobacterium tuberculosis. Depletion of IL-4 with a neutralizing mAb caused only evanescent reduction of lung infection, but when combined with i.n. inoculations of IgA anti-mycobacterial alpha-crystallin mAb and mouse rIFN-gamma, we observed a 40-fold reduction of the bacterial counts in the lungs at 3 wks following i.n. infection (p<0.001). In genetically deficient IL-4-/- BALB/c mice, infection in both lung and spleen was substantially reduced for up to 8 wks without further treatment. Reconstitution of IL-4-/- mice w…

Turquía y Giscard

2002

LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system, co-localizes with intracellular Listeria monocytogenes

2001

The Listeria monocytogenes surface protein ActA is an important virulence factor required for listerial intracellular movement by inducing actin polymerization. The only host cell protein known that directly interacts with ActA is the phosphoprotein VASP, which binds to the central proline-rich repeat region of ActA. To identify additional ActA-binding proteins, we applied the yeast two-hybrid system to search for mouse proteins that interact with ActA. A mouse cDNA library was screened for ActA-interacting proteins (AIPs) using ActA from strain L. monocytogenes EGD as bait. Three different AIPs were identified, one of which was identical to the human protein LaXp180 (also called CC1). Bind…

Effects of plant species in a horizontal subsurface flow constructedwetland – phytoremediation of treated urban wastewater withCyperus alternifolius …

2013

Abstract Plant species carry out a series of important biological, chemical and physical processes within a constructed wetland wastewater treatment system and make a significant contribution to wastewater purification. This paper compares two emergent macrophytes – Cyperus alternifolius L. and Typha latifolia L. – planted separately in a pilot horizontal subsurface flow system for the phytoremediation of treated urban wastewater in the West of Sicily (Italy). The total surface area of the three units within the pilot system was 99 m 2 . Six subunits were planted with two species and three subunits were left unplanted as the control. The main aim of the study was to demonstrate that, under …