Search results for "MACROMOLECULAR"
showing 4 items of 944 documents
A DNA‐Encoded FRET Biosensor for Visualizing the Tension across Paxillin in Living Cells upon Shear Stress
2022
Paxillin is a potential participant in the direct intracellular force transmission which is considered as the foundation of cells sensing and responding to extracellular environment. However, the detection of tension across paxillin has not been achieved due to lacking microsized tools. Herein, a paxillin tension sensor (PaxTs) based on Fluorescence Resonance Energy Transfer (FRET) technique was constructed. PaxTs can be expressed and assembled to FA sites spontaneously to visualize the tension across paxillin with FRET efficiency of ~62.4% in living cells. The tension across paxillin was found to decrease upon shear stress, in which the membrane fluidity and contractility of actin acted as…
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of t…
2009
The biological importance of microtubules in mitosis and cell division makes them an interesting target for the development of anticancer agents. Small molecules such as benzo[b]furans are attractive as inhibitors of tubulin polymerization. Thus, a new class of inhibitors of tubulin polymerization based on the 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan molecular skeleton, with electron-donating (Me, OMe or OH) or electron-withdrawing (F, Cl and Br) substituents on the benzene ring, was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization and cell cycle effects. Adding a methyl group at the C-3 position resulted in increased activity. The most prom…
Thermoelectric devices and supercapacitors based on nanostructured semiconducting polymers for energy production and storage
2017
Más de dos terceras partes de la energía generada por las fuentes convencionales se pierden como calor. Recuperar esas pérdidas de energía puede ayudar a crear una forma más eficiente de producir energía para el desarrollo sostenible de nuestra sociedad. Mediante el uso de generadores termoeléctricos es posible producir energía a partir de gradientes de temperatura de tal manera que la termoelectricidad puede ser una buena estrategia para la recolección y recuperación de energía. La eficiencia termoeléctrica suele ser dada por la figura adimensional de mérito, ZT. Actualmente, los materiales inorgánicos se usan comúnmente en aplicaciones termoeléctricas, sin embargo presentan varias desvent…
Direct visualization of pyrrole reactivity by confined oxidation in a Cyclodextrin Metal‐Organic Framework
2019
Metal-organic frameworks can be used as porous templates to exert control over polymerization reactions. Shown here are the possibilities offered by these crystalline, porous nanoreactors to capture highly‐reactive intermediates for a better understanding of the mechanism of polymerization reactions. By using a cyclodextrin framework the polymerization of pyrrole is restricted, capturing the formation of terpyrrole cationic intermediates. Single‐crystal X‐ray diffraction is used to provide definite information on the supramolecular interactions that induce the formation and stabilization of a conductive array of cationic complexes.