Search results for "MAGEA3"
showing 3 items of 3 documents
Estudio de marcadores de enfermedad mínima residual en neuroblastoma y de su posible aplicación clínica
2016
El neuroblastoma es el tumor sólido extracraneal más frecuente en la infancia y el cuarto en frecuencia en el conjunto global de neoplasias infantiles. Su incidencia en nuestro país, según el RNTI oscila entre 8-10 casos por millón de niños y año, por lo que su frecuencia supone alrededor de un 8-10% de todos los tumores en niños. Sin embargo, es el responsable de aproximadamente un 15% del total de muertes provocadas por cáncer pediátrico. La edad media del diagnóstico es de 22 meses, dos tercios de los casos se presentan antes de los 5 años de edad y en un 97% los pacientes tienen menos de 10 años. El tumor es más común en niños que en niñas, siendo el ratio niño/niña aproximadamente 1,3/…
A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma.
1991
Many human melanoma tumors express antigens that are recognized in vitro by cytolytic T lymphocytes (CTLs) derived from the tumor-bearing patient. A gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line. This gene shows no similarity to known sequences and belongs to a family of at least three genes. It is expressed by the original melanoma cells, other melanoma cell lines, and by some tumor cells of other histological types. No expression was observed in a panel of normal tissues. Antigen MZ2-E appears to be presented by HLA-A1; anti-MZ2-E CTLs of the original patient recognized two melanoma cell lines of other HLA-A1 patients that expressed the ge…
The Prevalence of Cancer-Associated Autoantibodies in Patients with Gastric Cancer and Progressive Grades of Premalignant Lesions.
2017
Abstract Background: Serum autoantibodies against tumor-associated antigens (TAAs) are detectable in early-stage gastric cancer patients; however, the time point during cancerogenesis when they appear in circulation is still obscure. Methods: In this study, we developed a recombinant antigen microarray and analyzed the prevalence of autoantibodies against 102 TAAs in 829 gastric cancer patients and 929 healthy controls from Caucasian and Asian populations, as well as 100 patients with chronic atrophic gastritis and 775 individuals staged according to different grades of intestinal metaplasia. Results: Six antigens, including CTAG1B/CTAG2, DDX53, IGF2BP2, TP53, and MAGEA3, were predominantly…