Search results for "MAI"

Dissipativity-Based Small-Gain Theorems for Stochastic Network Systems

2016

In this paper, some small-gain theorems are proposed for stochastic network systems which describe large-scale systems with interconnections, uncertainties and random disturbances. By the aid of conditional dissipativity and showing times of stochastic interval, small-gain conditions proposed for the deterministic case are extended to the stochastic case. When some design parameters are tunable in practice, we invaginate a simpler method to verify small-gain condition by selecting one subsystem as a monitor. Compared with the existing results, the existence-and-uniqueness of solution and ultimate uniform boundedness of input are removed from requirements of input-to-state stability and smal…

The ‘Open Garden of Politics’: The impact of open primaries for candidate selection in the British Conservative Party

2016

International audience; Since 2003, hundreds of open primaries for the selection of parliamentary candidates have been held by the British Conservative Party as a means of democratising party organisation and enhancing representativeness. In the run-up to the 2015 general election, only 26 primaries could be identified. This article will apply the analytical framework provided by Hazan and Rahat to demonstrate that the relative failure of the experiment in terms of intra-party competition, participation, representation and responsiveness is counterbalanced by the benefits brought by this procedure, both as a tool of party branding at the national level and as a strategy for raising the prof…

The Role the Static Maximization Approach Plays in Neoclassical Analyses

1994

This is an article on the methodology of economic thought. The critical assessment of the neoclassical research programme contained here basically comes from the contributions of J.M. Buchanan, Nobel prize winner in Economics 1986. These comments are aimed at pointing out the role that the static maximization approach plays in neoclassical analyses since L. Robbins and P. Samuelson’s influential contributions came about after World War II. Just to complement this basic purpose, I present in section 4 the alternative methodological foundations J.M. Buchanan proposes and uses to replace the static maximization approach when building public choice analyses and I sketch in section 5 several pe…

Digital Volunteers in Disaster Response: Accessibility Challenges

2019

The emergence of the Digital Humanitarian Volunteer (DHV) movements when disaster strikes have drawn the attention of researchers and practitioners in the emergency management and humanitarian domain. While there are established players in this rapidly developing field, there are still unresolved challenges, including accessibility of their digital tools and platforms. The purposes of this paper are twofold. First, it describes the background, impact and future potential of the DHV movement, and discusses the importance of universal design for the digital tools and platforms used for crowdsourcing of crisis information. Second, this paper shows how lack of concern for universal design and a…

Preventive maintenance versus cost of repairs in asset management: An efficiency analysis in wastewater treatment plants

2020

Abstract The operation and management of Wastewater Treatment Plants (WWTPs) is of paramount importance to guarantee the sustainability of water resources. Just like any other production process, wastewater treatment process involves different costs, such as: energy, personnel, maintenance and reagents. Regarding maintenance costs, they have become an issue of great concern to many operators in the last years. Maintaining the facilities in good condition ensures the proper performance of these infrastructures and reduces the risk of failures. It should be known that equipment breakdowns imply an increase in operating costs, with a high risk of generating an environmental damage due to the m…

Understanding the Importance of Proper Incentives for Critical Infrastructures Management – How System Dynamics Can Help

2016

International audience; Computer and information systems are now at the core of numerous critical infrastructures. However, their security management is by far not a trivial issue. Further, these systems, by their very nature, belong to the domain of complex systems, where system dynamics (SD) is an established method, which aims at modelling such systems, their analysis and understanding. Further, on this basis it enables simulation of various policies to properly manage complex systems. More precisely, through understanding of the basic elements of the whole mosaic and their interplay, proper incentives can be tested. And this is important, because proper incentives can lead to the desire…

Finding Software Bugs in Embedded Devices

2021

AbstractThe goal of this chapter is to introduce the reader to the domain of bug discovery in embedded systems which are at the core of the Internet of Things. Embedded software has a number of particularities which makes it slightly different to general purpose software. In particular, embedded devices are more exposed to software attacks but have lower defense levels and are often left unattended. At the same time, analyzing their security is more difficult because they are very “opaque”, while the execution of custom and embedded software is often entangled with the hardware and peripherals. These differences have an impact on our ability to find software bugs in such systems. This chapt…

Analysis of Activity States of Local Neuronal Microcircuits in Mouse Brain

2018

Time series of neuronal activity corresponding to different activity states in mouse brain are analyzed in the time domain and the time-frequency domain. The signals are associated with either a slow wave brain state or a persistent brain state. For both states, characteristic spectral features are identified and a simple detector is proposed that is able to identify the brain state with low latency and high accuracy. In practice, being able to monitor the brain state online and in real time is crucial for improved in vivoexperiments and, ultimately, for a causal understanding of brain dynamics.

Assembly of Transmembrane b-Type Cytochromes and Cytochrome Complexes

2016

Cytochromes are involved in charge-transfer reactions, and many cytochromes contain a transmembrane domain and are part of membrane-localized electron transfer chains. Protoporphyrin IX (heme b) is the first heme product in the tetrapyrrole/heme biosynthesis pathway. In contrast to c-type cytochromes, there is no need for a specialized machinery catalyzing covalent attachment of the heme molecule to a b-type apo-cytochrome, nor is the cofactor further modified, as in a-, d- and o-type cytochromes. Thus, formation of a holo-cytochrome is relatively simple for b-type cytochromes, and this class of proteins probably represents the most ancient members of transmembrane cytochromes. However, ass…

2018

ABC (ATP binding cassette) transporters, ubiquitous in all kingdoms of life, carry out essential substrate transport reactions across cell membranes. Their transmembrane domains bind and translocate substrates and are connected to a pair of nucleotide binding domains, which bind and hydrolyze ATP to energize import or export of substrates. Over four decades of investigations into ABC transporters have revealed numerous details from atomic-level structural insights to their functional and physiological roles. Despite all these advances, a comprehensive understanding of the mechanistic principles of ABC transporter function remains elusive. The human multidrug resistance transporter ABCB1, al…