Search results for "MALADIE"
showing 10 items of 135 documents
The implicit motor learning use as a therapeutic tool in frail elderly people
2016
To write, take, walk, talk is a part of our daily. Our motor ability is used to change depending on our environment and our skill, acquired thanks to our experience, learnings, and according to our age. We strive to find optimal solutions, to be more performants, more efficient. But we must be able to discern to act well and act to better discern. This « perception-action » coupling is the basis of the organization of motor control. Human can discern through several sensory systems (Visual, auditory, proprioceptive) intrinsic informations, coming from his own body, and extrinsic informations, from his environment. All of these informations are in the service of the movement and actions of d…
Risque phytosanitaire (ARP) portant sur Fusarium oxysporum f. sp. cubense (agent pathogène responsable de la maladie de Panama) pour les départements…
2018
Risque phytosanitaire (ARP) portant sur [i]Fusarium oxysporum[/i] f. sp.[u] cubense[/u] (agent pathogène responsable de la maladie de Panama) pour les départements d'Outre-mer
Le « reste à charge », participation du patient aux frais d'acquisition des produits de santé
2017
International audience
Approches bioinformatiques innovantes pour l’analyse de données de séquençage à haut-débit appliquées à l’étude de pathologies génétiques rares avec …
2020
In the last years, the advent of exome sequencing (ES) in diagnosis and in research led to the identification of the genetic bases of many Mendelian disorders, allowing many diagnostic wavering cases to be solved. Nevertheless, ES data analysis only leads to the identification of pathogenic or likely pathogenic variants in 30 to 45 % of the undiagnosed cases. Indeed, some limits exist, both at clinical, molecular and bioinformatic levels. The constant evolution of the clinical knowledge, of the number of genes involved in human diseases, and of the clinical-biological correlations, has a significant impact on data analysis, leading to a progressive improvement in diagnostic research. Limits…
Involvment of docosanoïc acid (C22=0), and of very long chain fatty acids (tetracosanoïc acid (C24=0), hexacosanoïc acid (C26=0) in Alzheimer's disea…
2013
In the brain and in the plasma of patients with Alzheimer’s disease (AD), marked accumulation of C22:0 and of very long chain fatty acids (C24:0 ; C26:0) have been reported. Important decreases of docosahexaenoic acid (DHA; C22:6 n-3) have also been described as well as quantitative and qualitative modifications of plasmalogens. Altogether, these lipid modifications suggest an implication of peroxisomal metabolism disorders in the physiopathology of AD. Therefore, the biological activities of C22:0, C24:0 and C26:0 have been studied on human neuronal cells SK-N-BE. On these cells, the lipotoxicity of fatty acids (C22:0, C24:0 and C26:0) leads to various cellular modifications: topographical…
Expertise préalable à la création d’un tableau de maladie professionnelle ou à l’élaboration de recommandations aux comités régionaux de reconnaissan…
2022
L’amiante est classé en tant que substance cancérogène avérée pour l’humain (groupe 1 du Centre International de Recherche sur la Cancer (CIRC)) depuis les années 70 pour le poumon et la plèvre. La monographie sur l’amiante actualisée en 2012 indique que des preuves suffisantes sont maintenant disponibles pour démontrer le lien entre l’exposition à l’amiante et les cancers du larynx et de l'ovaire. Dans cette monographie, les cancers du pharynx, de l’estomac et les cancers colorectaux sont considérés comme possiblement liés à une exposition à l’amiante, mais avec un niveau de preuve limité.A ce jour, seuls les cancers broncho-pulmonaires provoqués par l'inhalation de poussières d'amiante [t…
Involvement of Kv3.1 potassium chanels in 7-ketocholesterol, 24S-hydroxycholesterol and C24 : 0-induced lipotoxicity on 158N and BV-2 cells : relatio…
2017
Potassium (K+) is involved in the regulation of cellular excitability, cell cycle regulation, cell viability, neuroprotection and maintenance of microglial and oligodendrocytic functions. Potassium dysfunction, described in several neurodegenerative diseases such as Alzheimer's Disease (AD), multiple sclerosis (MS), Parkinson's disease and Huntington's disease, may be a potential therapeutic target. The underlying toxic mechanisms of these neurodegenerative pathologies involve oxysterols, which are oxidized cholesterol derivatives, and fatty acids including those associated with peroxisomal metabolism. 7-ketocholesterol (7KC), 24S-hydroxycholesterol (24S-OHC) and tetracosanoic acid (C24:0),…
Rethinking physical and rehabilitation medicine: new technologies induce new learning strategies
2010
International audience; Reeducation consists in training people injured by either illness or the vagaries of life to achieve the best fundionality now possible for them. Strangely, the subject is not taught in the normal educational curricula of the relevant professions. Reeducation thus tends to be developed anew with each patient, without recourse to knowledge of what such training, or assistance in such training, might be. However, new paradigms of reeducation are in fact possible today, thanks to advances in cognitive science and the development of new technologies such as virtual reality and robotics. In turn, they lead to the rethinking of the procedures of physical medicine, as well …
Safety and Pharmacokinetics of Glecaprevir/Pibrentasvir in Adults With Chronic Genotype 1–6 Hepatitis C Virus Infections and Compensated Liver Disease
2019
Background: Untreated, chronic hepatitis C virus (HCV) infection may lead to progressive liver damage, which can be mitigated by successful treatment. This integrated analysis reports the safety, efficacy, and pharmacokinetics (PK) of the ribavirin-free, direct-acting, antiviral, fixed-dose combination of glecaprevir/pibrentasvir (G/P) in patients with chronic HCV genotype 1-6 infections and compensated liver disease, including patients with chronic kidney disease stages 4 or 5 (CKD 4/5). Methods: Data from 9 Phase II and III clinical trials, assessing the efficacy and safety of G/P treatment for 8-16 weeks, were included. The presence of cirrhosis was determined at screening using a liver …
A chromosome map of the Flavescence dorée phytoplasma
2008
International audience; The Flavescence dorée phytoplasma (FD-P), a non-cultivable, plant-pathogenic bacterium of the class Mollicutes, is the causal agent of a quarantine disease affecting vineyards of southern Europe, mainly in southern France and northern Italy. To investigate FD-P diversity and phytoplasma genetic determinants governing the FD-P life cycle, a genome project has been initiated. A physical map of the chromosome of FD-P strain FD92, purified from infected broad beans, was constructed by performing restriction digests of the chromosome and resolving the fragments by PFGE. Single and double digestions of the chromosome with the enzymes SalI, BssHII, MluI and EagI were perfor…