Search results for "MAM"
showing 10 items of 1679 documents
Effects of undergrowth removal and edge proximity on ground beetles and vascular plants in urban boreal forests
2019
Urban forests are regularly managed for human safety and esthetic reasons, but they are crucial habitat for many species. Removals of undergrowth occur commonly in these forests, yet the ecological consequences of these operations are poorly understood. We sampled ground beetles (Coleoptera, Carabidae) and vascular plants along 20-m edge gradients in Finnish urban forests, in five stands treated 0.5–2.5 years earlier with undergrowth removal and in five untreated stands. We hypothesized that undergrowth removal and edge proximity would benefit opportunistic and open-habitat species, whereas shady-habitat species would be affected negatively. (1) Regarding carabids, diversity and evenness in…
Muscle Function Differences between Patients with Bulbar and Spinal Onset Amyotrophic Lateral Sclerosis. Does It Depend on Peripheral Glucose?
2021
Background: One of the pathogenic mechanisms of ALS disease is perturbed energy metabolism particularly glucose metabolism. Given the substantial difference in the severity and the prognosis of the disease, depending on whether it has a bulbar or spinal onset, the aim of the study was to determine metabolic differences between both types of ALS, as well as the possible relationship with muscle function. Materials and Methods: A descriptive, analytical, quantitative, and transversal study was carried out in hospitals and Primary Care centers in the region of Valencia, Spain. Fasting glucose and alkaline phosphatase (AP) levels in venous blood, muscle percentage, fat percentage, muscle streng…
Analyytikkojen suositusten vaikutus Helsingin Pörssissä noteerattuihin osakkeisiin 1993-1999
2000
Interacción entre receptores de estrógenos, hipoxia, angiogénesis y metabolismo tumoral en cáncer de mama
2017
El cáncer de mama ocupa el primer lugar en incidencia y muerte por neoplasia maligna en mujeres en el mundo occidental. Sin embargo, la gran heterogeneidad de la enfermedad, hace que haya una necesidad creciente de biomarcadores no sólo para el diagnóstico preciso, sino también para el abordaje del paciente que permitan una medicina personalizada y de precisión. En términos generales existen tres factores que influyen notablemente en la agresividad de un tumor mamario. Por una parte, prevalece una fuerte correlación entre la proliferación y el receptor de estrógenos (ER). Por otra parte, la angiogénesis es necesaria para el aporte de nutrientes al tumor y juega así un papel fundamental en l…
Angļu valodas apguves veicināšana pirmsskolā četrus līdz sešus gadus veciem bērniem
2018
Kvalifikācijas darbā “Angļu valodas apguves veicināšana pirmsskolā četrus līdz sešus gadus veciem bērniem” aplūkota aktuālā teorija un prakse agrīnas svešvalodas apguves jomā. Darba mērķis ir izpētīt angļu valodas agrīnas apguves veicināšanu atbilstīgi mūsdienīgas un bērncentrētas mācību darbības principiem pirmsskolā. Darba teorētiskajā daļā autore pievēršas teorijām, kas skaidro bērna valodas attīstību un tās lomu agrīnā svešvalodas apguvē. Darba empīriskajā daļā autore analizē savu profesionālo pieredzē, ieviešot pirmsskolā virkni mūsdienīgu angļu valodas apguves metožu, novērtē sasniegtos rezultātus, aplūko darbā sastaptos izaicinājumus un sniedz priekšlikumus to pārvarēšanai. Pētījuma …
Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.
2001
SPECIFIC AIMSTo identify the proprotein convertases responsible for maturation of the α-secretase ADAM10, we investigated the influence of PC7 and furin on ADAM10 processing and the resulting effect on amyloid precursor protein cleavage. We also examined the functional role of the ADAM10 prodomain by coexpression of a prodomain-deleted ADAM10 mutant together with its prodomain in trans.PRINCIPAL FINDINGS1. ADAM10 is proteolytically processed by PC7 and furinThe disintegrin metalloproteinase ADAM10 possesses α-secretase activity as well as a potential proprotein convertase recognition sequence (RKKR) after its prodomain. By amino-terminal sequencing of ADAM10 purified from bovine kidney plas…
Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain
2008
AbstractIFT172, also known as Selective Lim-domain Binding protein (SLB), is a component of the intraflagellar transport (IFT) complex. In order to evaluate the biological role of the Ift172 gene, we generated a loss-of-function mutation in the mouse. The resulting Slb mutant embryos die between E12.5 and 13.0, and exhibit severe cranio-facial malformations, failure to close the cranial neural tube, holoprosencephaly, heart edema and extensive hemorrhages. Cilia outgrowth in cells of the neuroepithelium is initiated but the axonemes are severely truncated and do not contain visible microtubules. Morphological and molecular analyses revealed a global brain-patterning defect along the dorsal–…
Nickel, lead, and cadmium induce differential cellular responses in sea urchin embryos by activating the synthesis of different HSP70s.
2004
Treatment with heavy metals, such as nickel, lead or cadmium, elicits different cellular stress responses according to the metal used and the length of treatment. In Paracentrotus lividus embryos the inducible forms of HSP70 (HSP70/72) are different in molecular mass from the constitutively expressed HSP75, and they can be used as markers of cellular stress. Even a short treatment with each metal induces the synthesis of HSP70/72 which remain stable for at least 20 h and differ little in their isoelectric points. Continuous treatment from fertilization with nickel or lead produces late irregular pluteus embryos, with peak HSP70/72 synthesis at blastula followed by the arrest of synthesis by…
Larval zebrafish as an in vitro model for evaluating toxicological effects of mycotoxins.
2020
The presence of mycotoxins in food has created concern. Mycotoxin prevalence in our environment has changed in the last few years maybe due to climatic and other environmental changes. Evidence has emerged from in vitro and in vivo models: some mycotoxins have been found to be potentially carcinogenic, embryogenically harmful, teratogenic, and to generate nephrotoxicity. The risk assessment of exposures to mycotoxins at early life stages became mandatory. In this regard, the effects of toxic compounds on zebrafish have been widely studied, and more recently, mycotoxins have been tested with respect to their effects on developmental and teratogenic effects in this model system, which offers …
Rapid changes in heat-shock cognate 70 levels, heat-shock cognate phosphorylation state, heat-shock transcription factor, and metal transcription fac…
2010
The aim of the present study was to analyze and compare the effects of several metals on the embryos of the sea urchin Paracentrotus lividus, a key species within the Mediterranean Sea ecosystem. Embryos were continuously exposed from fertilization to the following metals: 0.6 mg/l copper, 3 mg/l lead, and 6 mg/l nickel. The embryos were then monitored for metal responses at the gastrula stage, which occurred 24 h after exposure. A biochemical multi-experimental approach was taken and involved the investigation of the levels of HSC70 expression and the involvement of heat shock factor (HSF) and/or metal transcription factor (MTF) in the response. Immunoblotting assays and electrophoretic mo…