Search results for "MAM"
showing 10 items of 1679 documents
Leishmania tarentolae and Leishmania infantum in humans, dogs and cats in the Pelagie archipelago, southern Italy.
2021
Visceral leishmaniasis (VL) caused by Leishmania infantum is endemic in the Mediterranean basin with most of the infected human patients remaining asymptomatic. Recently, the saurian-associated Leishmania tarentolae was detected in human blood donors and in sheltered dogs. The circulation of L. infantum and L. tarentolae was investigated in humans, dogs and cats living in the Pelagie islands (Sicily, Italy) by multiple serological and molecular testing. Human serum samples (n = 346) were tested to assess the exposure to L. infantum by immunofluorescence antibody test (IFAT), enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) and to L. tarentolae by IFAT. Meanwhile, sera from do…
Estudio de los perfiles de expresión de microRNAs en líneas celulares de cáncer de mama triple negativo tratadas con doxorubicina: implicación de la …
2017
Entre los diferentes subtipos de cáncer de mama se encuentra el triple negativo, denominado así porque las células tumorales de este subtipo presentan baja expresión o carecen de receptores de estrógenos, receptores de progesterona, y receptores del factor de crecimiento epidérmico tipo II (HER2). Actualmente no existe una diana específica para el tratamiento de este tipo de cáncer de mama, caracterizado por ser muy agresivo, presentar alto riesgo de metástasis, un alto índice de recurrencia, y una bajo índice de supervivencia. Debido a la falta de dianas moleculares específicas, el tratamiento comúnmente utilizado es la quimioterapia. Dentro de los diferentes agentes quimioterápicos, se en…
Infanticide and Population Growth in the Bank Vole (Myodes glareolus): The Effect of Male Turnover and Density
2011
One major intrinsic factor affecting recruitment of young into a population is infanticide, the killing of conspecific young by adult males. It occurs in most mammal species, like our study species the bank vole (Myodes glareolus), and is widely accepted as an adaptive behavior, which may increase male fitness via nutritional gain, decreased competition, or an increased access to mates. A turnover of males in a population increases the risk of infanticide owing to a disruption of social structures. In a controlled field study, we tested the effects of total male turnover and density on juvenile recruitment and female space use in experimental bank vole populations. Juvenile recruitment decl…
Origination and extinction patterns of mammals in three central Western Mediterranean islands from the Late Miocene to Quaternary
2008
Abstract An overview of the population histories of three insular realms (Gargano palaeo-archipelago, Sardinia–Maritime Tuscany palaeo-bioprovince and the Sicilian insular complex) during the Late Miocene and Quaternary are here presented. The complexity of biodiversity changes in the islands is analysed to propose an interpretation of origination and extinction patterns. The study highlighted several important aspects of insular faunas. Evolutionary radiations were found to contribute significantly only to the Gargano faunal diversity, likely because the area was an archipelago at the time. Another interesting result is that large and small mammals do not disperse and become extinct all at…
Type II keratin cDNAs from the rainbow trout: implications for keratin evolution.
2002
From a teleost fish, the rainbow trout Oncorhynchus mykiss, we have cloned and sequenced cDNAs encoding five different type II keratins. The corresponding protein spots, as separated by 2D-PAGE of trout cytoskeletal preparations, have been identified by peptide mass mapping using MALDI mass spectrometry. Three of the sequenced keratins are expressed in the epidermis (subtype IIe), and two in simple epithelia and mesenchymal cells (subtype IIs). The IIs keratins are both orthologs of human K8. This leaves unsequenced only the trace component S3 of the biochemically established trout keratin catalog. A phylogenetic tree has been constructed from a multiple alignment of the rod domains of the …
Salmon lice in the Pacific Ocean show evidence of evolved resistance to parasiticide treatment
2022
AbstractParasitic salmon lice (Lepeophtheirus salmonis) threaten the economic and ecological sustainability of salmon farming, and their evolved resistance to treatment with emamectin benzoate (EMB) has been a major problem for salmon farming in the Atlantic Ocean. In contrast, the Pacific Ocean, where wild salmon are far more abundant, has not seen widespread evolution of EMB-resistant lice. Here, we use EMB bioassays and counts of lice on farms from the Broughton Archipelago, Canada—a core region of salmon farming in the Pacific—to show that EMB sensitivity has dramatically decreased since 2010, concurrent with marked decrease in the field efficacy of EMB treatments. Notably, these bioass…
Kvalitātes nosacījumi kontrastmammogrāfijā pie krūts vēža izmeklējumiem
2022
Autora izvēlētā bakalaura darba tēma - “Kvalitātes nosacījumi kontrastmamogrāfijā pie krūts vēža izmeklējumiem”. Bakalaura darbs sastāv no ievada daļas, teorētiskās daļas, pētnieciskās daļas, secinājumiem un ieteikumiem. Bakalaura darbā apskatīta un analizēta literatūra par krūts dziedzera anatomiju un fizioloģiju, krūts dziedzeru onkopatoloģijām, kontrastmamogrāfijas izmeklējumiem, izmeklējumu artefaktiem un protokolu vadlīnijām. Darba autore izvirzīja darba mērķi: noskaidrot kontrastmamogrāfijas nozīmi krūts vēža diagnostikā. Kā pētniecības metode tika izmantota - kvalitatīvā kontentanalīze.
La Natura come soggetto di diritto: l'approccio ecuadoriano
2022
All legal systems by now must confront the issue of environmental protection. The scope of this paper is to analyse the Ecuadorian approach, considering that it is the only legal system which, so far, has constitutionalized the rights of Nature, thus allowing a change in the status of Nature, from object to subject of law, overcoming the traditional approach of Western environmental law. The paper also aims to show how the theme of the rights of Nature offers a valuable opportunity for intercultural dialogue, and how the Ecuadorian experience represents, in this sense, a perfect mix between Western legal notions, such as damage, protection, or representation, and the ancestral knowledge of …
Expresión diferencial de microRNAs en tumores de mujeres jóvenes con cáncer de mama: Cribado de dianas moleculares
2015
El cáncer de mama constituye el cáncer invasivo más frecuente en mujeres, afectando a una de cada 8 mujeres a lo largo de su vida, siendo, además, la primera causa de muerte derivada de cáncer invasivo en la población española (15,5%). Las mujeres jóvenes representan únicamente el 3% del total de casos diagnosticados; sin embargo, estas pacientes presentan tumores de mayor tamaño e índice de proliferación, estando sobrerepresentados subtipos tumorales más agresivos y de peor pronóstico. Los microRNAs (miRNAs) son pequeñas moléculas de RNA no codificante, cuyo papel en la célula es regular la expresión de genes, bloqueando el paso de RNA mensajero a proteína. Su desregulación es típica en nu…
La fauna del pleistoceno inferior de la Sierra de Quibas (Abanilla, Murcia)
1999
El yacimiento kárstico cuaternario de la Sierra de Quibas (Abanilla, Murcia) ha proporcionado una amplia lista faunística constituida por 53 especies repartidas entre gasterópodos, miriápodos, anfibios, reptiles, aves y mamíferos. En el conjunto de los gasterópodos destaca Palaeoglandina, un género que se extingue en el resto de Europa durante el Plioceno y que se mantiene como relicto en el Pleistoceno de la Península Ibérica. Dos de las especies de aves determinadas, Gypaetus barbatus y Gerontieus eremita, y una de las serpientes, Elaphe cf. E. sealaris, apenas se hallan representadas en el registro fósil. Hay además varias especies de aves cuya aparición en Quibas supone la primera cita …