Search results for "MAM"

showing 10 items of 1679 documents

Koiran parvoviruksen fysikaaliset ominaisuudet

2007

koiran parvovirusominaisuudetatomivoimamikroskooppimikroskoopitparvovirukset
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Attēlu kritēriju izvērtējums krūts vēža skrīninga programmā

2021

Bakalaura darba tēma ir “Attēlu kritēriju izvērtējums krūts vēža skrīninga programmā”. Tēmas aktualitāti nosaka krūts vēža augstie saslimstības un mirstības rādītāji. Darba mērķis ir noskaidrot skrīninga mamogrāfijas attēlu kritēriju izpildi, veicot pētījumu Latvijas medicīnas iestādē. Teorētiskajā daļā aprakstīta piena dziedzeru anatomija, rentgenanatomija, krūts vēža klasifikācija, krūts vēža skrīninga programma - tās aktualitātes, skrīninga mamogrāfijas standartprojekciju tipizācijas svarīgums, ergonomikas principi un attēlu kritēriju izvērtējums. Pētniecības instruments ir darba autora veidotas abu standartprojekciju kritēriju tabulas, kurās tika apkopoti 50 skrīninga mamogrāfijas izmek…

kritērijiscreeningskrīningskrūts vēzismamogrāfijaMedicīna
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Mamogrāfijas attēlu kvalitātes kritēriju izvērtējums un korelācija ar pacientu diskomforta līmeni izmeklējuma laikā

2022

Bakalaura darba tēma ir “Mamogrāfijas attēlu kvalitātes kritēriju izvērtējums un korelācija ar pacienta diskomforta līmeni izmeklējuma laikā”. Tēmas aktualitāti nosaka augstie saslimstības rādītāji ar krūts vēzi sieviešu populācijā un tendence izlaist kārtējo rutīnas mamogrāfiju, kas nodrošina agrīnu krūts vēža diagnostiku, kā iemeslu visbiežāk norādot sāpīgu izmeklējumu pamatojoties uz iepriekšēju pieredzi. Darba mērķis ir noskaidrot kvalitatīva attēla kritērijus veicot mamogrāfijas izmeklējumu un veikt to korelāciju ar pacienta diskomforta līmeni izmeklējuma laikā. Bakalaura darbs sastāv no ievada, 4 nodaļām un 8 apakšnodaļām, secinājumiem un četriem pielikumiem. Teorijas daļā analizēta u…

kritērijiskrīningsdiskomfortskrūts vēzismamogrāfijaMedicīna
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Attēla kvalitātes izvērtēšana mamogrāfijas izmeklējumiem ar tomosintēzi sievietēm ar ievietotiem implantiem

2020

Visās Eiropas valstīs pēdējās desmitgadēs saslimšana ar krūts vēzi turpina pieaugt. Risks palielinās līdz ar vecumu. Krūts vēzis joprojām ir visizplatītākais ļaundabīgais audzējs un galvenais sieviešu vēža nāves cēlonis Eiropā. Pēc statistikas krūts vēzis ieņēma vadošo vēža vietu sievietēm. visās Eiropas valstīs. Mamogrāfijas skrīnings piedāvā iespēju agrīnā stadijā atklāt ļaundabīgas slimības, kuras attiecīgi ārstē agri, tādējādi samazinot mirstības līmeni. Lai pasargātu sevi no saslimšanas ar krūts vēzi un laicīgi diagnosticētu saslimšanas ar krūts audzējiem, arī sievietēm ar ievietotiem krūšu implantiem ir iespēja veikt mamogrāfijas izmeklējumus. Pētījuma galvenais uzdevums bija izvērtēt…

krūtsimplantimamogrāfijaMedicīna
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Kvalitatīva mamogrāfijas ar tomosintēzi izmeklējuma nosacījumi krūts vēža diagnostikā

2022

Bakalaura darba tēma “Kvalitatīva mamogrāfijas ar tomosintēzi izmeklējuma nosacījumi krūts vēža diagnostikā”. Bakalaura darba mērķis noskaidrot digitālās mamogrāfijas ar tomosintēzi kvalitatīva izmeklējuma nosacījumus krūts vēža diagnostikā. Pirmajā nodaļā analizēta krūts normālā anatomija un radioloģiskā anatomija. Otrajā nodaļā analizēta krūts vēža klīniskā aina, patomorfoloģija un radioloģiskā izmeklēšana. Trešajā nodaļā analizēta krūts rentgenogramma kraniokaudālā projekcija un mediolaterālā slīpā projekcija, pacienta pozicionēšana, ekspozīcijas un tehniskie parametri un attēla kvalitātes kritēriji. Ceturtajā nodaļā ir aprakstīta pētījuma metodoloģija un veiktā pētījuma rezultātu analīz…

kvalitatīvi attēla kritērijimamogrāfija ar tomosintēzikrūts dziedzeriskrūts vēzisattēla kvalitāteMedicīna
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Fabrication of DNA origami lattice on silicon surface for DNA-assisted lithography

2022

Metamaterials obtain new properties from having metallized nanoscale features that are often arranged in repeating patterns. In particular, there is a need to create metasurfaces with a negative refractive index. As nanoscale fabrication using conventional top-down methods can be both difficult and time-consuming, bottom-up techniques have gained growing interest. Especially, the DNA origami method can be utilized to assemble lattices with nanoscale features on 2D surfaces, which can then be metallized using DNA-assisted lithography (DALI). This thesis provides a full study of the DNA origami fishnet lattice assembly kinetics and optimization of lattice order on a silicon surface using liqu…

lattice theorysolid-liquid interfacepiiatomic force microscopynegative refractive indexsiliconDNAmetasurfacemetamaterialsDNA nanotechnologyDNA origamiatomivoimamikroskopiametamateriaalithilateoria
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Pain neuroscience education and physical exercise for patients with chronic spinal pain in primary healthcare: a randomised trial protocol.

2019

AbstractBackgroundChronic musculoskeletal pain affects more than 20% of the population, and the prevalence is increasing, causing suffering, loss of quality of life, disability, and an enormous expenditure on healthcare resources. The most common location for chronic pain is the spine. Many of the treatments used are mainly passive (pharmacological and invasive) and poor outcomes. The treatments currently applied in the public health system do not comply with the recommendations of the main clinical practice guidelines, which suggest the use of educational measures and physical exercise as the first-line treatment. A protocol based on active coping strategies is described, which will be eva…

lcsh:Diseases of the musculoskeletal systemSports medicinePsychological interventionChronic pain:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Study Protocol:Diseases::Nervous System Diseases::Neurologic Manifestations::Pain::Chronic Pain [Medical Subject Headings]0302 clinical medicineExercise/physiologyHealth careAdaptation PsychologicalMedicineTreatment protocolOrthopedics and Sports Medicine030212 general & internal medicine:Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings]education.field_of_studyPatient Education as Topic/methodsChronic pain:Anthropology Education Sociology and Social Phenomena::Education::Education Nonprofessional::Health Education::Patient Education as Topic [Medical Subject Headings]Middle Aged:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Adaptation Psychological [Medical Subject Headings]Primary careEjercicio físico:Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [Medical Subject Headings]Exercise TherapySpinal DiseasesChronic Pain/diagnosisSpinal Diseases/diagnosis:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Physical Therapy Modalities::Exercise Therapy [Medical Subject Headings]:Persons::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]Adultmedicine.medical_specialtyPopulationChronic spinal painAdaptation Psychological/physiology03 medical and health sciencesYoung AdultQuality of life (healthcare)Primary Health Care/methodsRheumatologyPatient Education as TopicAtención primaria de salud:Anthropology Education Sociology and Social Phenomena::Human Activities::Exercise [Medical Subject Headings]Humans:Persons::Persons::Age Groups::Adult [Medical Subject Headings]educationExercisePain neuroscience educationAgedPrimary Health Carebusiness.industryPhysical exercise:Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]:Diseases::Musculoskeletal Diseases::Bone Diseases::Spinal Diseases [Medical Subject Headings]Dolor crónicomedicine.diseaseExercise Therapy/methodsClinical trialPotocolos clínicoslcsh:RC925-935businessNeuroscienceEducational program030217 neurology & neurosurgery
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Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer ste…

2018

Despite marked advancements in its treatment, breast cancer is still the second leading cause of cancer death in women, due to relapses and distal metastases. Breast cancer stem cells (CSCs), are a cellular reservoir for recurrence, metastatic evolution and disease progression, making the development of novel therapeutics that target CSCs, and thereby inhibit metastases, an urgent need. We have previously demonstrated that the cystine-glutamate antiporter xCT (SLC7A11), a protein that was shown to be overexpressed in mammary CSCs and that plays a key role in the maintenance of their redox balance, self-renewal and resistance to chemotherapy, is a potential target for mammary cancer immunoth…

lcsh:Immunologic diseases. Allergy0301 basic medicinecancer stem cellmedicine.medical_treatmentImmunologylcsh:RC254-28203 medical and health sciences0302 clinical medicineBreast cancerCancer immunotherapyCancer stem cellbovine herpesvirus 4-based vector; cancer stem cell; immunotherapy; Mammary cancer; xCT; Immunology and Allergy; Immunology; OncologymedicineImmunology and Allergybovine herpesvirus 4-based vectorOriginal ResearchAntibody-dependent cell-mediated cytotoxicitybusiness.industryxCTCancerImmunotherapylcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseMetastatic breast cancer030104 developmental biologyOncology030220 oncology & carcinogenesisCancer researchMammary cancerimmunotherapyStem celllcsh:RC581-607businessOncoImmunology
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A novel solution based on scale invariant feature transform descriptors and deep learning for the detection of suspicious regions in mammogram images.

2020

Background: Deep learning methods have become popular for their high-performance rate in the classification and detection of events in computer vision tasks. Transfer learning paradigm is widely adopted to apply pretrained convolutional neural network (CNN) on medical domains overcoming the problem of the scarcity of public datasets. Some investigations to assess transfer learning knowledge inference abilities in the context of mammogram screening and possible combinations with unsupervised techniques are in progress. Methods: We propose a novel technique for the detection of suspicious regions in mammograms that consist of the combination of two approaches based on scale invariant feature …

lcsh:Medical technologyclassificationlcsh:R855-855.5computer-assisted image processingdigital mammographydeep learningOriginal Articlecomputing methodologiesClassification computer‐assisted image processing computing methodologies deep learning digital mammography
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Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of Atrip-Seckel syndrome

2020

ABSTRACT Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress response, the mutually dependent partners ATR and ATRIP, are among the known causes of Seckel syndrome. However, it remains unclear how their deficiency disrupts the development and function of the central nervous system (CNS). Here, we investigated the cellular and molecular consequences of ATRIP deficiency in different cell populations of the developing murine neural retina. We discovered that conditional inactivation of Atrip in photoreceptor neurons …

lcsh:MedicineMedicine (miscellaneous)315BlindnessMicechemistry.chemical_compoundImmunology and Microbiology (miscellaneous)Cell DeathneurodevelopmentStem CellsNeurodegenerationapoptosisneurodegenerationSyndromeCell biologyDNA-Binding Proteinsdna damage responsemedicine.anatomical_structurePhotoreceptor Cells VertebrateResearch Articlelcsh:RB1-214NeurogenesisNeuroscience (miscellaneous)Embryonic DevelopmentBiologyRetinaGeneral Biochemistry Genetics and Molecular Biologylcsh:PathologymedicineAnimalsAbnormalities MultipleProgenitor cellVision OcularAdaptor Proteins Signal TransducingCell ProliferationProgenitorRetinalcsh:RRetinalEmbryo Mammalianmedicine.diseasephotoreceptorDisease Models AnimalSeckel syndromechemistryvisual system developmentNerve DegenerationRetinal dysplasiaRetinal DysplasiaTumor Suppressor Protein p53Primordial dwarfismDNA DamageDisease Models & Mechanisms
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