Search results for "MAZ"

Oxcarbazepine does not affect the anticoagulant activity of warfarin.

1992

The possible interaction of the antiepileptic drug oxcarbazepine (OCBZ) on the anticoagulant effect of warfarin was investigated in 10 healthy male volunteers. After reaching steady-state conditions by repeated administration of warfarin, the prothrombin time (Quick value) was assessed before and after single (600 mg) and multiple dosing (450 mg twice daily in 1 week) of OCBZ. In 7 of the 10 volunteers with evaluable data, the prothrombin time was not significantly different (paired t test) from baseline either after single (p = 0.299) or repeated dosing (p = 0.333), indicating that OCBZ does not interact to any relevant extent with the hypothrombinemic effect of warfarin.

Micellar electrokinetic capillary chromatography for therapeutic drug monitoring of carbamazepine and its main metabolites.

1998

In carbamazepine (CBZ) therapy the concomitant monitoring of concentrations of CBZ and its metabolites is strictly recommended, primarily to avoid toxic side effects. Currently, clinical routine monitoring of CBZ is accomplished by high-performance liquid chromatography or immunological methods. In this study a micellar electrokinetic capillary chromatographic (MECC) method was developed for routine drug monitoring of CBZ and its main metabolites, carbamazepine 10,11-diol and carbamazepine 10,11-epoxide, in human serum or plasma samples. The MECC method enabled baseline separation of all analytes within 2.5 min. The assay revealed sufficient precision and sensitivity and the results of eith…

Carbamazepine transbuccal delivery: the histo-morphological features of reconstituted human oral epithelium and buccal porcine mucosae in the transmu…

2009

Transbuccal drug delivery is an attractive way of administration since several well-known advantages are provided, especially with respect to peroral management. Carbamazepine (CBZ) is an anticonvulsant which is useful in controlling neuropathic pain, and it is currently administered by peroral route, although its absorption and bioavailability is limited due to various factors. The oral cavity could be an interesting site for transbuccal CBZ delivery due to two properties: slow administration of constant low drug doses and less dose-related side effects. However, in transbuccal absorption a major limitation could be the low permeability of the mucosa which results in low drug bioavailabil…

Liver failure under valproic acid

2011

Valproic acid (VPA, 2-propylvaleric acid) is originally an antiepileptic drug, which has been in use for more than 30 years in over 100 countries. The clinical application of VPA has expanded in the last years. Approval has been granted by the FDA for treatment of migraine and cluster headache in 1996, and for treatment of mania and long-term prophylaxis of bipolar affective disorder in 1995. In ongoing studies, VPA has been reported to inhibit growth of several types of cancer cells; in addition, effects on neurodegeneration, and on virus replication in HIV infection have been demonstrated potentially expanding the application of VPA in the future. Despite a good tolerability of the drug, …

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Carbamazepine.

2020

Abstract Literature relevant to assessing whether BCS-based biowaivers can be applied to immediate release (IR) solid oral dosage forms containing carbamazepine as the single active pharmaceutical ingredient are reviewed. Carbamazepine, which is used for the prophylactic therapy of epilepsy, is a non-ionizable drug that cannot be considered “highly soluble” across the range of pH values usually encountered in the upper gastrointestinal tract. Furthermore, evidence in the open literature suggests that carbamazepine is a BCS Class 2 drug. Nevertheless, the oral absolute bioavailability of carbamazepine lies between 70 and 78% and both in vivo and in vitro data support the classification of ca…

Deduzione e principio: giustificazioni dimostrative nella logica filo-indipendente (FI) di Hintikka

2010

GAIML: A New Language for Verbal and Graphical Interaction in Chatbots

2008

Natural and intuitive interaction between users and complex systems is a crucial research topic in human-computer interaction. A major direction is the definition and implementation of systems with natural language understanding capabilities. The interaction in natural language is often performed by means of systems called chatbots. A chatbot is a conversational agent with a proper knowledge base able to interact with users. Chatbots appearance can be very sophisticated with 3D avatars and speech processing modules. However the interaction between the system and the user is only performed through textual areas for inputs and replies. An interaction able to add to natural language also graph…

Džuzepes Tomazi di Lampedūzas romāns "Gepards": recepcija un teksta analīze psihoanalītiskā aspektā

2021

Maģistra darba mērķis ir izpētīt rakstnieka, prinča Džuzepes Tomazi di Lampedūzas romānu “Gepards” (Il Gattopardo) (1958), lai atklātu tā lomu Eiropas (arī Latvijas) literatūrā un sasaisti ar psihoanalīzes idejām un praksēm. Aplūkota Lampedūzas un viņa sievas – psihoanalītiķes, baroneses Volfas – biogrāfija, raksturots romāns “Gepards” un izvērsta tā recepcija. Īpaša uzmanība ir veltīta romāna varoņu tēlojumam. Viņi tiek raksturoti, pievēršoties varoņu dvēseliskajām problēmām. Kopumā “Gepards” daļēji atklājas kā ideju romāns, kas ir ļoti populārs Itālijā, bet ne tik pazīstams darbs Latvijā, savukārt “literalizētā psihoanalīze” – auglīgs paņēmiens arī turpmākiem literatūrzinātnes pētījumiem.

Deep neural networks leveraging different arrangements of molecular fingerprints to define a novel embedding for virtual screening procedure

2022

Impact of reforestations with exotic and native species on water repellency of forest soils

2017

Forest duff layer is usually water repellent due to the hydrophobic organic compounds resulting from degradation of tree tissues. Transition from hydrophobic to wettable conditions, or vice versa, is largely controlled by water content. The objective of this investigation was to assess the influence of soil moisture on the degree of soil water repellency (WR) in exotic and native tree forests. Occurrence of WR was investigated by the water drop penetration time (WDPT) and the ethanol percentage (EP) tests. Sampling was conducted in the forest soils of two exotic species (Pinus pinaster, P, and Eucaliptus camaldulensis, E), used in the past for reforestation, and two native species (Quercus …