Search results for "MBL"

The unique fossil assemblage from the Lode Quarry (Upper Devonian, Latvia)

2001

The unique fossil fauna from the Lode clay quarry, lower Frasnian, Latvia, includes a diverse ichthyofauna of at least 15 taxa of agnathans and gnathostomes, representing most of the major taxa of Devonian vertebrates. Six new fish taxa (five species and one genus) were discovered during the last ten years. Exceptionally well-preserved juvenile fishes (<i>Asterolepis ornata, Lodeacanthus gaujicus</i>) provide unique data on ontogenetic change. Diverse arthropods are recorded. Parasitic platyhelminth remains in juvenile fish bodies is their first discovery in the fossil record, and represents the oldest parasitic association ever found. A complete faunal and floral list for the L…

Il Louvre si apre al contemporaneo e invita l’artista americano Cy Twombly a realizzare un’opera permanente

2010

Luminescent supramolecular heterometallic macrocycles and their encapsulation on cholate gels

2018

The metal complex formed by coordination of Zn(II) to 1,7-bis(4-methylpyridine)-4-(2- naphthylmethyl)-1,4,7-triazaheptane (ZnL2+) was reacted in aqueous solution with [Pd(NO3)2(en)] and [Pt(NO3)2(en)] salts to form the self-assembled heterometallic macrocycles [Zn2L2Pd2(en)2]8+ and [Zn2L2Pt2(en)2]8+, respectively. Pd(II) and Pt(II)- coordination modulates the original emission of ZnL2+ arising from the presence of the naphthalene chromophore and the formation of the macrocycles can be monitored due to the PET process occurring with coordination of Pd(II) and Pt(II) to the pyridine units of ZnL2+. Additionally, several studies reveal that these heteromacrocycles can be encapsulated in Zn(II)…

Expression inactivation of SMARCA4 by microRNAs in lung tumors

2014

SMARCA4 is the catalytic subunit of the SWI/SNF chromatin-remodeling complex, which alters the interactions between DNA and histones and modifies the availability of the DNA for transcription. The latest deep sequencing of tumor genomes has reinforced the important and ubiquitous tumor suppressor role of the SWI/SNF complex in cancer. However, although SWI/SNF complex plays a key role in gene expression, the regulation of this complex itself is poorly understood. Significantly, an understanding of the regulation of SMARCA4 expression has gained in importance due to recent proposals incorporating it in therapeutic strategies that use synthetic lethal interactions between SMARCA4-MAX and SMAR…

Self-assembly of a M4L6 complex with unexpected S4 symmetry

2014

Using 1,4-diaminobenzene and 2-formylpyridine as simple building blocks results in a 1D ligand (rod, L2) to 2D (M4L4 grid, C1) to 3D (S4 symmetrical M4L6, C2) complexes upon sequential addition of Cu(I) and Fe(II) ions. The complex C2 can be seen as the smallest possible pseudo-tetrahedron with S4 symmetry. peerReviewed

Semantic Word Error Rate for Sentence Similarity

2016

Sentence similarity measures have applications in several tasks, including: Machine Translation, Paraphrase Iden- tification, Speech Recognition, Question-answering and Text Summarization. However, measures designed for these tasks are aimed at assessing equivalence rather than resemblance, partly departing from human cognition of similarity. While this is reasonable for these activities, it hinders the applicability of sentence similarity measures to other tasks. We therefore propose a new sentence similarity measure specifically designed for resemblance evaluation, in order to cover these fields better. Experimental results are discussed.

The Hsc/Hsp70 Co-Chaperone Network Controls Antigen Aggregation and Presentation during Maturation of Professional Antigen Presenting Cells

2011

The maturation of mouse macrophages and dendritic cells involves the transient deposition of ubiquitylated proteins in the form of dendritic cell aggresome-like induced structures (DALIS). Transient DALIS formation was used here as a paradigm to study how mammalian cells influence the formation and disassembly of protein aggregates through alterations of their proteostasis machinery. Co-chaperones that modulate the interplay of Hsc70 and Hsp70 with the ubiquitin-proteasome system (UPS) and the autophagosome-lysosome pathway emerged as key regulators of this process. The chaperone-associated ubiquitin ligase CHIP and the ubiquitin-domain protein BAG-1 are essential for DALIS formation in mou…

Oxidation Enhances Human Serum Albumin Thermal Stability and Changes the Routes of Amyloid Fibril Formation

2014

Oxidative damages are linked to several aging-related diseases and are among the chemical pathways determining protein degradation. Specifically, interplay of oxidative stress and protein aggregation is recognized to have a link to the loss of cellular function in pathologies like Alzheimer's and Parkinson's diseases. Interaction between protein and reactive oxygen species may indeed induce small changes in protein structure and lead to the inhibition/modification of protein aggregation process, potentially determining the formation of species with different inherent toxicity. Understanding the temperate relationship between these events can be of utmost importance in unraveling the molecul…

Decoding the Folding of Burkholderia glumae Lipase: Folding Intermediates En Route to Kinetic Stability

2012

The lipase produced by Burkholderia glumae folds spontaneously into an inactive near-native state and requires a periplasmic chaperone to reach its final active and secretion-competent fold. The B. glumae lipase-specific foldase (Lif) is classified as a member of the steric-chaperone family of which the propeptides of alpha-lytic protease and subtilisin are the best known representatives. Steric chaperones play a key role in conferring kinetic stability to proteins. However, until present there was no solid experimental evidence that Lif-dependent lipases are kinetically trapped enzymes. By combining thermal denaturation studies with proteolytic resistance experiments and the description of…

Acetylcholine-binding protein in the hemolymph of the planorbid snail Biomphalaria glabrata is a pentagonal dodecahedron (60 subunits).

2012

Nicotinic acetylcholine receptors (nAChR) play important neurophysiological roles and are of considerable medical relevance. They have been studied extensively, greatly facilitated by the gastropod acetylcholine-binding proteins (AChBP) which represent soluble structural and functional homologues of the ligand-binding domain of nAChR. All these proteins are ring-like pentamers. Here we report that AChBP exists in the hemolymph of the planorbid snail Biomphalaria glabrata (vector of the schistosomiasis parasite) as a regular pentagonal dodecahedron, 22 nm in diameter (12 pentamers, 60 active sites). We sequenced and recombinantly expressed two ∼25 kDa polypeptides (BgAChBP1 and BgAChBP2) wit…