Search results for "MDA"

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

2012

Toll-like receptor 3 (TLR3) is a pattern-recognition receptor known to initiate an innate immune response when stimulated by double-stranded RNA (dsRNA). Components of TLR3 signaling, including TIR domain-containing adapter inducing IFN-α (TRIF), have been demonstrated to contribute to dsRNA-induced cell death through caspase-8 and receptor interacting protein (RIP)1 in various human cancer cells. We provide here a detailed analysis of the caspase-8 activating machinery triggered in response to Poly(I:C) dsRNA. Engagement of TLR3 by dsRNA in both type I and type II lung cancer cells induces the formation of an atypical caspase-8-containing complex that is devoid of classical death receptors…

Identitātes problēmas un trimdas diskurss Tahara Ben Dželuna romānos

2015

Darbs pēta Magribas (Ziemeļāfrikas) tautu - marokāniešu, alžiriešu un tunisiešu identitātes problēmas imigrācijas kontekstā, un analīzē ar šo tēmu saistītus marokāniešu rakstnieka Tahara Ben Dželuna romānus. Pētījumā tiek izmantota literārā diskursa analīze, kurā ir iekļauta gan valodniecība, gan literatūrzinātne, gan kultūras un starpkultūru stūdijas. Mentalitāšu atšķirības, kas izpaužas reliģijas, kultūras un tradīciju jomā, kļūst par Ziemeļāfrikas izcelsmes imigrantu nespējības iemesli pilnīgi integrēties Francijas sabiedrībā. Tahars Ben Dželuns savos romānos raksturo šo fenomēnu kā trimdu, kuras veids var atšķirties un ir atkarīgs no cilvēka dzīves pieredzes un uztveres. Ben Dželuna rom…

Liriskais varonis Ovidija elēģijās: no ironizējošā līdz skumjajam mīlniekam

2016

Bakalaura darba Liriskais varonis Ovidija elēģijās: no ironizējošā līdz skumjajam mīlniekam mērķis ir, izpētot Ovidija Mīlas elēģijas un Skumjās elēģijas, noskaidrot, kā Ovidijs manipulē, attīsta un veido šo darbu liriskos varoņus attiecībā gan pret viņa paša mērķiem un vēsturisko realitāti, gan potenciālajiem elēģiju lasītājiem un darbu kontekstu kopumā. Darbā tiek apskatīta gan teorētiskā literatūra par liriskā varoņa un vēstījuma konstruēšanu, gan atzītu pētnieku darbi, kas apskata distances lielumu starp Ovidiju kā autoru un tā darbos redzamajiem liriskajiem varoņiem. Paralēli pētnieku viedokļiem, bakalaura darba autors sniedz savu viedokli gan par Ovidija elēģiju lirisko varoņu rakstur…

Co-activation of VEGF and NMDA receptors promotes synaptic targeting of AMPA receptors

2016

A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior

2016

Vascular endothelial growth factor (VEGF) is known to be required for the action of antidepressant therapies but its impact on brain synaptic function is poorly characterized. Using a combination of electrophysiological, single-molecule imaging and conditional transgenic approaches, we identified the molecular basis of the VEGF effect on synaptic transmission and plasticity. VEGF increases the postsynaptic responses mediated by the N-methyl-D-aspartate type of glutamate receptors (GluNRs) in hippocampal neurons. This is concurrent with the formation of new synapses and with the synaptic recruitment of GluNR expressing the GluN2B subunit (GluNR-2B). VEGF induces a rapid redistribution of Glu…

Sarkandaugavas, Jaunmīlgrāvja un Vecmīlgrāvja ģeogrāfisks apraksts

1937

Vidzemes zemnieki 18. gadsimta 2. pusē Augusta Vilhelma Hupeļa rakstos

1931

Vēsture: Latvijas Universitātes Žurnāls, 2019, Nr. 7/8

2019

Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Neg…

2015

BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal to its ED50 at 72 h (117 μM). Exposure of cells to BC-11, either pre-absorbed with a soluble preparation of the N-terminal fragment of urokinase-plasminogen activator (uPa), or in co-treatment with two different EGFR inhibitors, indicated that: (i) BC-11 acts via binding to the N-terminus of the enzyme where uPa- and EGF receptor-recognizing sites are present, thereby abrogating the growth-sustaining effect resulting from receptor binding

A Novel Series of 2-Carboxytetrahydroquinolines Provides New Insights into the Eastern Region of Glycine Site NMDA Antagonists

2000

A series of potent 4-substituted tetrahydroquinolines has been synthesized and biologically tested in order to refine the eastern region of the pharmacophore model for glycine site NMDA antagonists concerning the assessment of lipophilicity, flexibility, and hydrogen bonding. Displacement studies on rat cortical membranes using [ 3 H]-5,7-dichlorokynurenic acid as a radioligand indicated that binding affinities are markedly enhanced when additional hydrogen-accepting groups are introduced into the eastern region of the 2-carboxytetrahydroquinolines. Among the most potent ligands were some urea, sulfonylurea, and crown ether compounds as interesting leads for new diagnostics, especially for …