Search results for "MEDICATION"

Selective Inhibition of STAT3 with Respect to STAT1: Insights from Molecular Dynamics and Ensemble Docking Simulations

2016

STAT3 protein, which is known to be involved in cancer development, is a promising target for anticancer therapy. Successful inhibitors of STAT3 should not affect an activity of closely related protein STAT1, which makes their development challenging. The mechanisms of selectivity of several existing STAT3 inhibitors are not clear. In this work, we studied molecular mechanisms of selectivity of 13 experimentally tested STAT3 inhibitors by means of extensive molecular dynamics and ensemble docking simulations. It is shown that all studied inhibitors bind to the large part of the protein surface in an unspecific statistical manner. The binding to the dimerization interface of the SH2 domain, …

Domestication of a Robotic Medication-Dispensing Service Among Older People in Finnish Lapland

2020

This paper presents a case study on a robotic medication-dispensing service used in the everyday lives of older people in Finnish Lapland through the concept of domestication. The study took an ethnographic approach. A total of 11 service users, practical nurses, and other health-care professionals participated; the service users averaged age 81 years (M= 81.4, SD = 5.4). The data comprised semistructured interviews complemented by observations and photographs at service users’ homes. We concluded that the domestication of the service was successful, although the service users sometimes felt that it limited their lives. The service users stated that learning and subsequently using the servi…

Rendering in corso...

2022

Introduzione al libro "Gaming" di Alexander R. Galloway Introduction to Alexander R. Galloway's "Gaming" book

Cardiovascular Management Self-efficacy: Psychometric Properties of a New Scale and Its Usefulness in a Rehabilitation Context.

2015

Self-efficacy beliefs have been shown to affect various effective health-promoting behaviors in patients. Unfortunately, availability of reliable and valid measures of self-efficacy in cardiovascular diseases (CVDs) is still very limited. Background: Self-efficacy beliefs have been shown to affect various effective health-promoting behaviors in patients. Unfortunately, availability of reliable and valid measures of self-efficacy in cardiovascular diseases (CVDs) is still very limited. Purpose: The aims of this study were to present a new scale measuring self-efficacy beliefs in managing CVD and to examine its psychometric properties. Methods: The study involved 172 patients (mean age = 66.4…

Disease activity states, reasons for discontinuation and adverse events in 1038 Italian children with juvenile idiopathic arthritis treated with etan…

2017

The advent of biologic medications has increased considerably the potential for treatment benefit in juvenile idiopathic arthritis (JIA), with clinical remission being now achievable in a substantial proportion of patients. However, there is a need of data from the real world of clinical practice to evaluate thoroughly the efficacy and safety profile of the biologic agents currently approved.

Surgical treatment of medication-related osteonecrosis of the jaws with addiction of L-PRF: preliminary results

2018

A muscarinic mechanism inhibiting the release of noradrenaline from peripheral adrenergic nerve fibres by nicotinic agents.

1968

Designing of microcontroller based Syringe Pump with variable and low delivery rates for the administration of small volumes

2015

Delivering medications and fluids intravenously is a common practice in modern medical procedures. Administering medications or fluids directly into a patient's blood circulation results in a predictable and immediate absorption of the drug or fluid administered, this may play a vital role in the treatment of certain acute conditions which require immediate action by drugs or fluids. Syringe Pumps are highly useful in delivering a precise quantity of the substance at specific periods of time as required. This research presents a proposal to create a cost effective working prototype of syringe pump for variable and low delivery rates for the administration of small volumes. The presented Syr…

Altered processing of sensory stimuli in patients with migraine.

2014

Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these d…

Integrated treatment of first episode psychosis with online training (e-learning): study protocol for a randomised controlled trial

2014

Background: The integrated treatment of first episode psychosis has been shown to improve functionality and negative symptoms in previous studies. In this paper, we describe a study of integrated treatment (individual psychoeducation complementary to pharmacotherapy) versus treatment as usual, comparing results at baseline with those at 6-month re-assessment (at the end of the study) for these patients, and online training of professionals to provide this complementary treatment, with the following objectives: 1) to compare the efficacy of individual psychoeducation as add-on treatment versus treatment as usual in improving psychotic and mood symptoms; 2) to compare adherence to medication,…