Search results for "MEG"
showing 10 items of 1641 documents
Human genetic polymorphisms and risk of viral infection after solid organ transplantation.
2021
The immune system plays a key role in the host defense against viral pathogens. A signaling cascade is activated upon infection involving a variety of molecules such as pattern-recognition receptors (PRRs), interleukins or antiviral interferons. Long-term immunosuppression after solid organ transplantation (SOT) mainly abrogates adaptive T-cell-mediated responses, thus highlighting the relative contribution of innate immunity. Single-nucleotide polymorphisms (SNPs) within genes coding for PRRs or soluble mediators have been associated with differential susceptibility to viral infections among SOT recipients. A protective effect against cytomegalovirus (CMV) infection or disease has been att…
Marcadores inmunológicos de protección frente al citomegalovirus en el trasplante alogénico de precursores hematopoyéticos
2015
En la actualidad, la mayoría de centros emplean la estrategia del tratamiento antiviral anticipado guiado por PCR en tiempo real (monitorización virológica) para prevenir el desarrollo de enfermedad orgánica en el alo-TPH. Esta estrategia es muy eficaz, pero tiene como efecto indeseado la toxicidad asociada al sobretramiento de los pacientes, de modo que es potencialmente mejorable. En este sentido, la presente tesis doctoral aporta información sobre las cinéticas de la DNAemia viral en el compartimento sistémico, como una herramienta útil en el manejo de la infección activa por el CMV . Por otra parte, tras el trasplante, es de vital importancia la reconstitución funcional de los linfocito…
In partenza verso il majhul. Italiani ed egiziani in fuga per Alessandria d'Egitto
2019
This article analyzes two novels set in Alexandria. The first one is "Cortile a Cleopatra" by the Italian writer Fausta Cialente. The second one is "Nobody sleeps in Alexandria" (Lâ ahad yanâm fî'l-Iskandariyya) by Ibrahim Abdel Meguid. The analysis focus on actions that characterize the genre of travel literature in which the traveler is expected to perform two actions: leaving then returning. If the traveler does not come back to the starting point, his experience is not considered as "travel", rather as "change of residence". But it does not always work out that way. In the two novels, the protagonists leave with intentions of ever coming back. At the same time, their departure includes …
Philogenetics of Sea Urchin Tripneustes gratilla using Cytochrome Oxidase Subunit 1 Gene
2021
Sea urchin Tripneustes gratilla is multifunction organism that can be used as potential food source because of its high nutrient content. This organism can also be utilized bioindicator of sea waters and as a modal of organism for studying biology’s purposes. The purposes of this research is studying Filogenetic of sea urchin T. gratilla from waters of Wasior and Serui. The research has been doing at the Biotechnology Laboratory of the state of University of Papua on November to December 2009. The sample was extracted by using Chelex 10 % and was amplified with PCR technic (polymerase chain reaction). Sequencing of CO I gens (cythocrome oxidase subunit I) was done using sequencher ABI 377 (…
Mass determination, subunit organization and control of oligomerization states of keyhole limpet hemocyanin (KLH).
1997
Analytical dark-field scanning transmission electron microscopy (STEM) of freeze-dried unstained specimens of keyhole limpet hemocyanin (KLH; from Megathura crenulata, a prosobranch gastropod) gave a molecular mass of 400 kDa for the subunit of KLH1 and of 345 kDa for the subunit of KLH2, which confirms our published values from SDS/PAGE. Within the 400-kDa KLH1 subunit we identified, by limited proteolysis, isolation of fragments and N-terminal sequencing, eight distinct 45-60 kDa functional domains (termed 1a through 1h) and determined their sequential arrangement. The KLH1 domains differ biochemically and immunologically from each other and from the previously characterized seven domains…
Keyhole Limpet Hemocyanin Type 2 (KLH2): Detection and Immunolocalization of a Labile Functional Unit h
2000
Keyhole limpet hemocyanin (KLH) is a mixture of two hemocyanin isoforms, termed KLH1 and KLH2. Within KLH1 eight oxygen-binding functional units (FUs), 1-a to 1-h, have been identified, in contrast to KLH2, which was previously thought to be organized in seven FUs (2-a to 2-g). By limited proteolysis of KLH2 subunits, isolation of the polypeptide fragments, and N-terminal sequencing, we have now identified an eighth FU of type h, with a molecular mass of 43 kDa. This is unusually small for a FU h from a gastropodan hemocyanin. It is also shown that KLH2 didecamers can be split into a stable and homogeneous population of decamers by dialysis against 50 mM Tris/HCl, pH 7.5, in the absence of …
From COVID-19 to future electrification: Assessing traffic impacts on air quality by a machine-learning model
2021
The large fluctuations in traffic during the COVID-19 pandemic provide an unparalleled opportunity to assess vehicle emission control efficacy. Here we develop a random-forest regression model, based on the large volume of real-time observational data during COVID-19, to predict surface-level NO(2), O(3), and fine particle concentration in the Los Angeles megacity. Our model exhibits high fidelity in reproducing pollutant concentrations in the Los Angeles Basin and identifies major factors controlling each species. During the strictest lockdown period, traffic reduction led to decreases in NO(2) and particulate matter with aerodynamic diameters <2.5 μm by –30.1% and –17.5%, respectively, bu…
Three Amadisian Poems by Pere Gimferrer, José Manuel Lucía Megías and Luis Alberto de Cuenca
2020
Análisis literario de las representaciones de Urganda la Desconocida en textos poéticos de Luis Alberto de Cuenca, Pere Gimferrer y José Manuel Lucía Megías, publicados a partir de 1985. La Desconocida es uno de los seres sobre-naturales más originales de las letras hispánicas. El sincretismo que revelan sus orígenes sufrió una profunda revisión a lo largo del Amadís de Gaula, de Garci Rodríguez de Montalvo, factor que redundó en su importancia en el imagi-nario literario del siglo XVI. De la mano de tres de los poetas que mejor conocen la tradición literaria del Medioevo, se valorarán las significaciones éticas y estéticas de esta insólita resurrección poética, muy diferente en cada uno de…
Infecció activa pel citomegalovirus (CMV) en el pacient amb malalties associades a inflamació en absència d’immunosupressió canònica
2014
El CMV desperta interès com a patògen en diferents tipus de malalties inflamatòries en absència d'immunosupressió canònica. S'ha vist que pacients immunocompetents, especialment aquells qui presenten sepsi severa, sovint experimenten episodis d'infecció activa pel CMV. Malgrat la disponibilitat d'informació que suggereix causalitat patogènica del CMV en aquest marc clínic, els assajos clínics controlats mitjançant l'ús de teràpia antiviral, en són ben pocs. La motivació d'aquesta tesi, que es presenta com compendi de publicacions i està integrada per cinc treballs de recerca que es reprodueixen a continuació, és la necessitat de donar resposta a una qüestió fonamental emergent: si el CMV té…
Una necrópolis megalítica en el Pico Jano
1989
UNA NECROPOLIS MEGALITICA EN EL PICO JANO H ace tiempo que se tenfan notic ias sobre la existen-cia de túmulos en los montes de Dobarganes y Enterrías (Vega de Liébana, Cantabria), localizados por Gonzalo Gómez, que había publicado alguno de ellos en la prensa regional 1. A rafz de diversas charlas mantenidas con vecinos de la zona sobre tradiciones de tesoros enterrados, se recogió el dicho popular: Entre los Co-rros y Palmedián está ente-rrado el tesoro del moro Galán. Ambos topónimos siguen denominando lugares concre-tos en la actualidad, y están recogidos en el mapa 1 :25.000 del Instituto Geográf ico Nacional, si bien el segundo aparece transcrito como Valmed ián. En base a estas infor…