Search results for "MEL"
showing 10 items of 6009 documents
Safety and immunogenicity of the PRAME cancer immunotherapeutic in metastatic melanoma: results of a phase I dose escalation study
2016
Purpose The PRAME tumour antigen is expressed in several tumour types but in few normal adult tissues. A dose-escalation phase I/II study (NCT01149343) assessed the safety, immunogenicity and clinical activity of the PRAME immunotherapeutic (recombinant PRAME protein (recPRAME) with the AS15 immunostimulant) in patients with advanced melanoma. Here, we report the phase I dose-escalation study segment. Patients and methods Patients with stage IV PRAME-positive melanoma were enrolled to 3 consecutive cohorts to receive up to 24 intramuscular injections of the PRAME immunotherapeutic. The RecPRAME dose was 20, 100 or 500 µg in cohorts 1, 2 and 3, respectively, with a fixed dose of AS15. Advers…
Brief an Johann Gottfried Herder
1797
Salute orale e diabete mellito di tipo I (IDDM): indagine su un campione di soggetti in età pediatrica
2004
Incorporación de elementos traza en conchas de melanopsis durante el crecimiento : posibilidades de aplicación en paleoecología
1988
El objetivo del presente trabajo está encaminado al estudio de las variaciones de oligoelementos en la concha de un gasterópodo de agua dulce del género Melanopsis (U dufouri (FERUSSAC), con dos morfotipos) y si éstas tienen que ver, o no, con la fluctuación de una serie de parámetros ambientales. La importancia del trabajo radica en la posibilidad de la aplicación paleoecológica de sus resultados, ya que el género MelanopsÍs tiene un abundante registro fósil durante todo el Cenozoico. La incorporación de oligoelementos se efectúa a medida que la concha va creciendo por acreción; lo ideal sería que tal crecimiento fuera circadiano, ya que se podría seguir día a día, sobre la concha, la fluc…
Comparison of essential oil components and in vitro anticancer activity in wild and cultivated Salvia verbenaca.
2015
The objectives of our research were to study the chemical composition and the in vitro anticancer effect of the essential oil of Salvia verbenaca growing in natural sites in comparison with those of cultivated (Sc) plants. The oil from wild (Sw) S. verbenaca presented hexadecanoic acid (23.1%) as the main constituent, while the oil from Sc plants contained high quantities of hexahydrofarnesyl acetone (9.7%), scarce in the natural oil (0.7%). The growth-inhibitory and proapoptotic effects of the essential oils from Sw and Sc S. verbenaca were evaluated in the human melanoma cell line M14, testing cell vitality, cell membrane integrity, genomic DNA fragmentation and caspase-3 activity. Both t…
COVID-19 in Severe Asthma Network in Italy (SANI) patients: Clinical features, impact of comorbidities and treatments
2020
To the Editor Since the end of February 2020 Italy, first non- Asian Country, has reported an ever increasing number of COronaVIrus Disease 19 (COVID-19) patients, which has reached over 200,000 confirmed Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infected subjects and resulted in more than 34000 deaths (data updated to June 19th, 20201).Patients with asthma are potentially more severely affected by by SARS-CoV-2 infection 2 and it is well established that respiratory viral infections are associated with severe adverse outcomes in patients with asthma, including increased risk of asthma exacerbation episodes 3. Nonetheless, according to the epidemiological studies publishe…
La Universidad en la época de Melchor Cano
2008
Análisis de la evolución de la Universidad española en el siglo XV y XVI
MELCOR per lo Studio Integrale di Sequenze Incidentali su Reattori PWR da 900 MWe e valutazioni preliminari d'impatto a breve e medio raggio
2014
Il presente documento è stato preparato nel corso della seconda annualità dell'AdP ENEA-MSE nell'ambito dell'obiettivo B-Task B_1 (Sviluppo di una Metodologia per Valutazioni di Sicurezza in Condizioni Incidentali o di Pre-Emergenza) della Linea Progettuale 1 (Sviluppo competenze scientifiche nel campo della sicurezza nucleare). Esso riporta i principali risultati della simulazione MELCOR di un transitorio del tipo “short term Station Blackout (SBO)” con possibile rottura dei tubi a U del GV (Steam Generator Tube Rupture - SGTR) indotta da stress termici e un lavoro preliminare di raccolta di informazioni sulle potenzialità presentate da alcune piattaforma di simulazione ad oggi utilizzate …
Cyano-Phycocyanin: Mechanisms of Action on Human Skin and Future Perspectives in Medicine
2022
Cyano-phycocyanin is one of the active pigments of the blue-green algae and is usually isolated from the filamentous cyanobacteria Arthrospira platensis Gomont (Spirulina). Due to its multiple physiological functions and non-toxicity, cyano-phycocyanin may be a potential substance for the topical treatment of various skin diseases. Considering that the conventional medicine faces drug resistance, insufficient efficacy and side effects, the plant origin compounds can act as an alternative option. Thus, the aim of this paper was to review the wound healing, antimicrobial, antioxidative, anti-inflammatory, antimelanogenic and anticancer properties and mechanisms of cyano-phycocyanin topical ac…
Dziedātājas Bejonse Vizuālā albuma vēstījuma analīze un sievietes reprezentācija tajā
2015
Bakalaura darba tēma ir “Dziedātājas Bejonse Vizuālā albuma vēstījuma analīze un sievietes reprezentācija tajā”. Darba mērķis ir noskaidrot, kā tiek reprezentēta sieviete dziedātājas „Beyonce” Vizuālajā albumā un kādi melnādaino feminisma aspekti atklājās 10 analizētājās dziesmās. Darba teorētiskajā daļā ir aprakstītas teorētiskās izpratnes par melnādaino feminismu, tā problēmjautājumiem, populāro mūziku un slavenību kultūru. Empīriskajā daļā ar kontentanalīzes palīdzību atlasītas biežāk fiksētās zīmes un atslēgas vārdi, kas analizēti ar semiotiskās analīzes palīdzību. Fokusa grupas dalībnieces darbā veidoja jaunas biežāk fiksēto zīmju nozīmes un atklāja jaunas idejas par 10 Vizuālā albuma …