Search results for "MEP"

Mosses as biomonitors of atmospheric heavy metal deposition : Spatial patterns and temporal trends in Europe

2010

In recent decades, mosses have been used successfully as biomonitors of atmospheric deposition of heavy metals. Since 1990, the European moss survey has been repeated at five-yearly intervals. Although spatial patterns were metal-specific, in 2005 the lowest concentrations of metals in mosses were generally found in Scandinavia, the Baltic States and northern parts of the UK ; the highest concentrations were generally found in Belgium and south-eastern Europe. The recent decline in emission and subsequent deposition of heavy metals across Europe has resulted in a decrease in the heavy metal concentration in mosses for the majority of metals. Since 1990, the concentration in mosses has decli…

Assessment of Renewable Sources for the Energy Consumption in Malta in the Mediterranean Sea

2016

The main purpose of this paper is to analyze the energy production in the Maltese islands, focusing on the employment of renewable energies in order to increase their energy independence. The main renewable source here proposed is wave energy: thanks to a strategic position, Malta will be able to produce electrical energy using an innovative type of Wave Energy Converter (WEC) based on the prototype of a linear generator realized by University of Palermo. The use of this new technology will be able to cut down the electrical energy production from traditional power plants and, consequently, the greenhouse gas emissions (GHG). Wave energy source and off-shore photovoltaic (PV) technology are…

Grasp-specific motor resonance is influenced by the visibility of the observed actor

2016

AbstractMotor resonance is the modulation of M1 corticospinal excitability induced by observation of others' actions. Recent brain imaging studies have revealed that viewing videos of grasping actions led to a differential activation of the ventral premotor cortex depending on whether the entire person is viewed versus only their disembodied hand. Here we used transcranial magnetic stimulation (TMS) to examine motor evoked potentials (MEPs) in the first dorsal interosseous (FDI) and abductor digiti minimi (ADM) during observation of videos or static images in which a whole person or merely the hand was seen reaching and grasping a peanut (precision grip) or an apple (whole hand grasp). Part…

Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold-Hopping Approach.

2020

Abstract Astacin metalloproteinases, in particular meprins α and β, as well as ovastacin, are emerging drug targets. Drug‐discovery efforts have led to the development of the first potent and selective inhibitors in the last few years. However, the most recent compounds are based on a highly flexible tertiary amine scaffold that could cause metabolic liabilities or decreased potency due to the entropic penalty upon binding to the target. Thus, the aim of this study was to discover novel conformationally constrained scaffolds as starting points for further inhibitor optimization. Shifting from flexible tertiary amines to rigid heteroaromatic cores resulted in a boost in inhibitory activity. …

Effects of low-gamma tACS on primary motor cortex in implicit motor learning

2019

Abstract In the primary motor cortex (M1), rhythmic activity in the gamma frequency band has been found during movement planning, onset and execution. Although the role of high-gamma oscillatory activity in M1 is well established, the contribution of low-gamma activity is still unexplored. In this study, transcranial alternating current stimulation (tACS) was used with the aim to specifically modulate low-gamma frequency band in M1, during an implicit motor learning task. A 40 Hz-tACS was applied over the left M1 while participants performed a serial reaction time task (SRTT) using their right hand. The task required the repetitive execution of sequential movements in response to sequences …

Energy and environmental benefits of circular economy strategies: The case study of reusing used batteries from electric vehicles

2019

Abstract According to recent literature and technical analyses, used batteries from electric vehicles can still be used, before the final treatment at the end-of-life, in stationary applications that are usually less stressing than the automotive ones. In this framework, a circular economy inspired pathway is emerging between the building and the transportation sector, generally called “second life” of batteries. Used batteries from electric vehicles can be re-used in residential buildings together with renewable electricity generation technologies to improve the matching between the highly variable electricity generation from renewables and the electricity demand in buildings. This study a…

MEMORIA MOTORIA Protocollo di riabilitazione cognitiva dei disturbi del movimento, il ruolo della corteccia motoria primaria. Utilizzo di metodiche d…

l'obiettivo della presenti tesi è stato quello di verificare il ruolo della corteccia motoria primaria in un test cognitivo di memorizzazione e riconoscimento di immagini di movimento suddivisi in sequenza. Sono stati utilizzati strumenti di modulazione dell'attività cerebrale quali la TMS ( stimolazione magnetica transcranica) e per la registrazione dei MEP (potenziali evocati motori) e la tDCS (stimolazione cerebrale a corrente diretta) e per la modulazione dell'attività cerebrale durante lo svolgimento del compito cognitivo. Questi studi sono stati condotti grazie alla partecipazione di soggetti sani e soggetti con lesione cerebrale dell'emisfero desrtro. I risultati ottenuti sembrano di…

Beliefs and preferences regarding biological treatments for severe asthma

2020

Background: Severe asthma is a serious condition with a significant burden on patients' morbidity, mortality, and quality of life. Some biological therapies targeting the IgE and interleukin-5 (IL5) mediated pathways are now available. Due to the lack of direct comparison studies, the choice of which medication to use varies. We aimed to explore the beliefs and practices in the use of biological therapies in severe asthma, hypothesizing that differences will occur depending on the prescribers’ specialty and experience. Methods: We conducted an online survey composed of 35 questions in English. The survey was circulated via the INterasma Scientific Network (INESNET) platform as well as throu…

Characteristics and treatment regimens across ERS SHARP severe asthma registries

2020

Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals.This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases.Analysis of data from 3236 patients showed many …

Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1)…

2014

Although the addition of the HCV NS3/4A protease inhibitors boceprevir and telaprevir to pegylated interferon (peginterferon) alfa plus ribavirin has improved sustained virological response (SVR) in treatment-naive and treatment-experienced patients infected with hepatitis C virus (HCV) genotype 1, the regimens have a high pill burden and are associated with increased rates and severity of adverse events, such as anaemia and rash. The efficacy and safety of the combination of simeprevir, a one pill, once-daily, oral HCV NS3/4A protease inhibitor, plus peginterferon alfa 2a plus ribavirin were assessed in treatment-naive patients with HCV genotype 1 infection.In QUEST-1, a phase 3, randomise…