Search results for "MEP"
showing 10 items of 209 documents
Boosting working memory with accelerated clocks
2021
Our perception of time varies with the degree of cognitive engagement in tasks. The perceived passage of time accelerates while working on demanding tasks, whereas time appears to drag during boring situations. Our experiment aimed at investigating whether this relationship is mutual: Can manipulated announcements of elapsed time systematically affect the attentional resources applied to a cognitive task? We measured behavioral performance and the EEG in a whole report working memory paradigm with six items of different colors that each had to be reported after a short delay period. The 32 participants were informed about the current time after each 20 trials, while the clock was running at…
TRPV1 channels as putative targets in the cannabinoid-mediated synaptic activity of hippocampal neurons
Endocannabinoids (eCBs) play a critical part in pathophysiological conditions rooted on neuronal excitability such as epilepsy. eCBs seem to be involved in neuroprotection, putatively acting on the cannabinoid receptor type 1 (CB1r), but also on Transient Receptor Potential Vanilloid type 1 channels (TRPV1). Indeed, CB1r and TRPV1 are involved in the transduction of stimuli at synaptic level, though exact molecular mechanisms are far from being unveiled. Thus, we aimed to investigate the role of CB1r/TRPV1 interplay in the rat hippocampal neurotransmission by whole-cell patch clamp technique to evaluate excitatory bioelectric activity in the CA1. We pharmacologically manipulated this pathwa…
Ar dabas aizsardzību saistīto terminu lietojums uzņēmumu mājas lapu tekstos
2021
Uzņēmumi savās mājas lapās var izmantot ar dabas aizsardzību (DA) saistītus terminus, lai sabiedrība tos uztvertu noteiktā veidā. Šī bakalaura darba mērķis ir analizēt DA terminu lietojumu desmit izvēlētu uzņēmumu mājas lapu tekstos, kas ņemti no piecām dažādām nozarēm. Galvenās pētījuma metodes ir literatūras apskats, absolūtā biežuma analīze un diskursa analīze. Dati parāda, ka automašīnu ražotāji savās mājaslapās izmanto visvairāk DA terminu, savukārt apģērbu firmas izmanto vismazāk DA terminu. Lielākā daļa atrasto DA terminu ir lietvārdi. Tiek secināts, ka uzņēmumus, kas savās mājaslapās lielākoties izmanto DA terminus no „vides risinājumu” kategorijas, var uztvert kā dabai draudzīgākus…
Assessment of genetically modified cotton GHB614 × T304‐40 × GHB119 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 …
2018
International audience; The three-event stack cotton GHB614 x T304-40 x GHB119 was produced by conventional crossing to combine three single events, GHB614, T304-40 and GHB119. The genetically modified organisms (GMO) Panel previously assessed the three single cotton events and did not identify safety concerns. No new data on the single cotton events that could lead to modification of the original conclusions on their safety were identified. Based on the molecular, agronomic, phenotypic and compositional characteristics, the combination of the single cotton events and of the newly expressed proteins in the three-event stack cotton did not give rise to food and feed safety concern. The GMO P…
Alternative Energy Policy for Mitigating the Asynchrony of the Wind-Power Industry’s Supply Chain in Brazil
2018
High dependency on hydroelectricity has revealed drawbacks in the security of power supplies as a consequence of the climate variability in South America. Under these conditions, Brazil is starting to consider alternative renewable sources for energy production, seeking to avoid periods of scarcity while also promoting clean technologies in its electricity market. Since 2004, wind power has shown a significant rise in terms of installed capacity in this country. Despite increases in wind-power units, Brazil suffers from delays in setting up its transmission infrastructure, which affects the performance of the wind-power supply chain. This chapter presents a simulation model that helps asses…
Synthesis, crystal structure, DFT calculations, Hirshfeld surface, vibrational and optical properties of a novel hybrid non-centrosymmetric material …
2019
This present work undertakes the study of a novel organic–inorganic hybrid material, which has been obtained successfully by an acid-base reaction at room temperature and structurally studied by the single crystal X-ray diffraction method. (C10H15N2)2H2P2O7 crystallizes in the triclinic system with the non-centrosymmetric space group P1 with the following lattice parameters: a = 5.9159(2) Å, b = 13.8451(6) Å, c = 14.5973(5) Å, ? = 74.507(2)°, ? = 89.980(2)°, ? = 89.231(2)° with V = 1152.06(8) Å3 and Z = 2. The X-ray structural analysis supported by a detailed Hirshfeld 2D fingerprint plots has been performed to elucidate the different inter-contacts in the crystal structure mainly associate…
Hallinnan näkökulmia huumeriippuvuuden hoitoon Suomessa vuosina 1965-2005
2011
Late Breaking Abstract - Dose-ranging study of mepolizumab in eosinophilic COPD
2018
Background: Patients with eosinophilic COPD & frequent exacerbations may benefit from mepolizumab (MEP) treatment. Objective: Assess efficacy & safety of 2 MEP doses vs placebo (PBO) in COPD with blood eosinophils ≥150 cells/µL [screening] or ≥300 cells/µL [prior yr], history of ≥2 moderate/≥1 severe exacerbations & ICS+≥2 bronchodilator maintenance therapies (ICS+MT). Methods: Phase III, randomised, PBO-controlled, double-blind, parallel-group trial (METREO); patients received SC MEP 100mg, MEP 300mg or PBO plus ICS+MT, every 4 wks for 52 wks. Primary endpoint: rate/yr of moderate (systemic corticosteroids/antibiotics)/severe(hospitalisation or death) exacerbations. Secondary endpoints inc…
Dzelzceļa ritošā sastāva radīto emisiju atmosfērā matemātisko novērtēšanas metožu salīdzinošā analīze
2018
Maģistra darbā veikta dzelzceļa transporta (kravas dīzeļlokomotīvju, pasažieru dīzeļvilcienu un elektrovilcienu) analīze un inventarizācija pēc to tehniskās specifikācijas, enerģijas patēriņa un gaisa piesārņojošo vielu emisijām. Izvērtētas Starptautiskās dzelzceļu savienības un Eiropas Vides aģentūras emisiju novērtēšanas aprēķina metodes, kuras metodoloģiski ir līdzīgas (tiek izmantoti emisiju faktori un degvielas patēriņa rādītāji), taču sniedz atšķirīgus rezultātus. Darba rezultāti liecina, ka UIC metode ir piemērotāka dzelzceļa ritošā sastāva emisiju novērtēšanai augstākas detalizācijas pakāpes dēļ. Balstoties uz UIC metodiku un emisiju faktoriem, izstrādāts emisiju kalkulators kravas …
Musteloidea (Carnivora, Mammalia) del Mioceno Superior de Venta del Moro (Valencia, España)
2011
The purpose of the present work is to describe the Musteloidea from the Late Miocene locality of Venta del Moro (Valencia, Spain). We have identified the following species: Martes ginsburgi nov. sp., Lutra affinis Gervais, 1859, Plesiogulo monspessulanus Viret, 1939 and Promephitis alexejewi Schlosser, 1924. Besides Plesiogulo monspessulanus which was already described in this locality and in Las Casiones (MN 13, Teruel Basin), we are approaching an unedited Musteloidea assemblage from the Miocene of the Iberian Peninsula. The m1 of Martes ginsburgi nov. sp. is similar in size and morphology to the Asian species of the genus, M. anderssoni and M. zdanskyi, but it differs in having a very wi…